<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31393

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDNTNIGGAGQGSAIHDSRNGMPSLTPNINRNSAFGDSHVGRVHINGMTKNAVDPSQAEDASTVNIKSTKSMELPELPHITQGFFPFSKLISRSVQQSWNDLSDLITEMADIKVSPQEQNSLQLPASGKSFGNQSPENLRKKARILDFAHAKRAEFIKLLVLSQWSRQAADVSKLIDLQNFIRTRHQAYMGALQGIGDMKRDLVQAQVANPDLTTALEVLSKGKVSSMSDLGYKPPRSLTGKDTLKRLQKINRIISVRLALYDSVPRAFHSYSIHDGRVTFVVPNEFELDLSIGQEDESSQLYFVDIRFLFNPSSPNLKGRIFNEFDVKINDALRNNGLSGCFDLLHSLVLTNKINILFKQAMELARGLWYDVLRVELLHRTLVVHYWTQKAGAKSWLEIGIKSGRICGENDSYRHPNLGLRWIRDGQEVDSEEIEFNTKSLSMESILRSVIALHISHILSSAYCIISESLLYSAGRLSLQAQLTRTEPGDCGLTIQLTESRHLSVSIEPMSGASIISATPSAQERLDNDRSSDKSSAEDIAARVARLRCMAAIDEIESNVKMLGFETVNPRSLKIDFRRLFPNNVLRFSFFWHHLWERNWIVAATSSMDGDNWWVVQLQTTTTAESHSVFDASTHISSTLRSAQAISGSFFHVNQNIGYPSFADLGHYLSGILAVHTNARYLADLQTVDFYPPLQRLVIEPNLQVPEIFMRYEAANIPEVFRIALPSGLKSRVRTKGTIRLAFHGVDPCKKVATIVAYGNLLIPIKAFSALNSTRDHSLVFQKRGTGFAIRLLAPPGRPVIPKLMENLQRLDCILSIFECLQRKKMETRSLSLSHVTFAYGPEKDLLATLKIETSMPSSSMELDPIFLASRTKSLFHLRLGLSFEFPNPHRRIQKSIESTLNHSTTDAGLDTVAELLLLTLPLMRALDQILMNPSNRQPLRVQVTVRNAKTFQIHYPGQSFRFQLVATHHLSHMVWILKELSSPKERSSQDQLKLRLRERLYNSKGDGWRGLGNGVVAETGKVGNLLTELDRCFEASSTPGLTPEVKASGSKSFSQQLTAENGNVEGTLSESATLIPTPNATSTRHKTGDTTQNADIIMID
Length1107
PositionTail
OrganismAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.07
Grand average of hydropathy-0.235
Instability index48.64
Isoelectric point9.01
Molecular weight123485.53
Publications
PubMed=16372010

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31393
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     383.97|     106|     374|     506|     613|       1
---------------------------------------------------------------------------
  506-  613 (171.17/128.32)	SRhLSVSIE.PMSGASIISATPSAQERLDNDRSSDkSSAEDIAARVARLRCMAAIDEIESNVKMLGFETVNPRSL...KIDF.....RRLFPNNVLRFSFF.WHHLWERNWIVAATSS
  816-  878 (52.00/29.57)	...............................................RLDCILSIFECLQRKKM...ET...RSLslsHVTFaygpeKDLLATLKIETSMP.SSSM.ELDPIFLASRT
  884-  989 (160.79/111.04)	LR.LGLSFEfPNPHRRIQKSIESTLNHSTTDAGLD.TVAELLLLTLPLMRALDQILMNPSNRQPLRVQ.VTVRNA...K.TF.....QIHYPGQSFRFQLVaTHHLSHMVWILKELSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     211.64|      72|     375|      20|     122|       2
---------------------------------------------------------------------------
   28-  107 (108.19/101.29)	PSLTPNINrnsAFGDSHVGRvHINGMTKNaVDPSQAEDASTV...NIKSTKSMELPELPHITQGFFPFSKLISRSvqqSWNDL
  630-  671 (54.66/24.07)	...................................AESHSVF...DASTHISSTLRSAQAISGSFFHVNQNIGYP...SFADL
 1046- 1091 (48.78/17.31)	PGLTPEVK...ASGSKSFSQ.QLTAENGN.VEGTLSESATLIptpNATSTR................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.46|      40|     264|     735|     780|       8
---------------------------------------------------------------------------
  735-  780 (59.24/64.21)	LKSRVR.....TKGT.IRLAFHGVdpckkVATIVAYGNLLIPI.KAFSAlNST
  999- 1045 (57.22/42.18)	LKLRLRerlynSKGDgWRGLGNGV.....VAETGKVGNLLTELdRCFEA.SST
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31393 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGVVMDNTNIGGAGQGSAIHDSRNGMPSLTPNINRNSAFGDSHVGRVHINGMTKNAVDPSQAEDASTVNIKSTKSM
2) PEVKASGSKSFSQQLTAENGNVEGTLSESATLIPTPNATSTRHKTGDTTQNADIIMI
1
1050
77
1106










Molecular Recognition Features






MoRF SequenceStartStop




NANANA