<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31391

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMDNATTGRPGHAPDTQTPSNGDNLRNGSFHINGAAKGDKDHDPDKESYAGKPRIDGHRALPEIPHITQGFFPFSTLVNRSVQQCWNELSDLITELAAIHVSPHSSVPLLPVNGKSPGNQSPENVQKKLRILDFAHAKRAEFIKLLVLSQWSRRARDVSKLIDLQNFIRARHQAFVDALQRVGEMKRDLVQAQVANPDLQTALEILSKGRLESLADLGYKSSKLLTARGALRRLHKINRIISARLALHDLIPHPFRTYRVHDGRVTFVVRGEFELDLSIGAESELSQFFFVDIRFLYSPSSNIPKGRMSNEIDAKINEKLRDSGLTGCFNFLHGLVLTNKIHILFKQAIELAKGLWSETLRVELLHRTLVIQYWTLKPGPKSWIEIGVKSGNGDADSQGLGVPCLGLRWMRDGQEVNSRDIEFDPEDLSMECLLRSVIALHISYLLSSAYGILSEYSLFSSGTLSSHAILNVTEPGECQLSVQLTGSRHLRVSIEPMSGAVILSATPGLLERFESDASLDRSTIDDLVARVSRLRCIAAIEELESNVRILGFETVSPKGLRNDIRKVFPANVLRFSLFWHPLWERNWVVAATSSITSDNWWVVRLRRSSEVATDFSVSDTSVPLCSGHSMSDTFLATSHQTRSSSFPDLGYCLSGMVAIYANVSYLSDLHSVEFHPPLCALKVESDLQIPDIFIRYQVSNLPRALQLVLPAGLKRKNLLKDTVRLAFHGIDRHKNSAIFVAYGNLVGPWTDLCTLISKSDSSLVFKQGGSGFALRLLAPAGRPVIVQLFKSLQTLECTLSILDFLRQRRLTPQSLSLTHIAFAYGPGRDLSATIEMGLSEVPSSAELDPVRVLARTDPLLCLTLGIRFKHPNPHRRVQGSLAAILNHASNEAGLDFVTEVLSFTLPLMRALEQITSNASRQEPFRLQVIVRNAYTFLLHYTYQGFRFQLTTRQHSGQLTWVLRELSSPEAGPGHDQFKARLRGTLYHSKGNGWKGLGNGVVADAEGVSNVIRALDGCFTGAQHNTWLPRETKSEQDYSTQPAPENQSQTGAPSQAGMANDTKMTANFVNDKSLQRNPVVSNAADVITID
Length1093
PositionTail
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Fumigati.
Aromaticity0.07
Grand average of hydropathy-0.172
Instability index46.18
Isoelectric point8.76
Molecular weight121219.84
Publications
PubMed=16372009

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31391
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.05|      21|      51|     182|     203|       1
---------------------------------------------------------------------------
  182-  203 (31.16/29.05)	ALQRVGEMKRdLVQAQVANPDL
  234-  254 (34.89/26.41)	ALRRLHKINR.IISARLALHDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.34|      54|      76|     842|     897|       2
---------------------------------------------------------------------------
  842-  897 (89.64/73.03)	LSEVPSSA.ELDPVR..VLART..DPLLCLTL.GIRFKHPNphRRVQGSLAAILNH.ASNEAG
  915-  975 (75.69/53.46)	LEQITSNAsRQEPFRlqVIVRNayTFLLHYTYqGFRFQLTT..RQHSGQLTWVLRElSSPEAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.02|      15|      51|     622|     636|       3
---------------------------------------------------------------------------
  622-  636 (30.29/19.76)	SDT.SV....PLCSGHSMSD
  671-  690 (17.73/ 8.46)	SDLhSVefhpPLCALKVESD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     211.01|      56|      72|     484|     539|       5
---------------------------------------------------------------------------
  438-  478 (37.72/19.12)	..........LR.SVIALHISYLLSSA....YGILSEYSlfSSGTLSSHAILNVTE......
  484-  539 (88.44/55.23)	LSVQLTGSRHLRVSIEPMSGAVILSAT....PGLLERFE..SDASLDRSTIDDLVARVSRLR
  554-  610 (84.85/52.67)	LGFETVSPKGLRNDIRKVFPANVLRFSlfwhP.LWERNW..VVAATSSITSDNW..WVVRLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.18|      30|     186|     121|     152|       7
---------------------------------------------------------------------------
  121-  152 (47.69/32.44)	P.GNQSPE...NVQKKLRilDFAHAKRAEFIKLLVL
  308-  341 (45.48/25.34)	PkGRMSNEidaKINEKLR..DSGLTGCFNFLHGLVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.78|      19|     419|     205|     223|      11
---------------------------------------------------------------------------
  205-  223 (31.62/19.06)	TALEILSKGRLESLADLGY
  637-  655 (35.17/22.02)	TFLATSHQTRSSSFPDLGY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31391 with Med14 domain of Kingdom Fungi
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