<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31390

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDNATVGGPRRASESPDNVSSTPFPQERVNQSGDSGDRRNRSIFHNGAVKGAQGPGQHIETHTGKDGINESEGLPELAHITQGFFPFSTLVNRSVQQCWNDLSELVTELAAIQVSPHGQMPSTPANGKAPGDQSPENLQKKTRILDFAHAKRAEFIKLLVLSQWSRQAGDVSRLIDLQNFIRNRHQAFMDALQRIGDMKRDLVQAQVANPDLKTALEVLSKGRVVSITDLGYEAPKQLTAKGALKRLHKINRIISARLALHDTIPRPFRTYRVHDGRATFVVQGEFELDLSVGEESKSSQFFFVDIRFLFSPSSHVPKGRLSNELDVQVNDRLRDNGLKGCFDFLHGLVLTNKITILFKQAVELARGLWSDVLRVELLHRTLVVQYWALKLGAKSWIEIGIKSGRKPHDVKDSGVPYLALRWIRDGQEVDSTSVEFDADDLSMERLLRSIIALHISHLLSATYSILNQRSLFATGLLSLQALLNTNEPGKCQLLAQLTVSRHLRVSIEPMSGAIVLSADPSPLDRSESDSSLEKSSVDDIVSRVSRLRCIAALEEAESTVKILGFETVSPRGLKADVRKILPPNILRFALFWHPFWDRSWIVAATSSTDGDSWWVIHLRRPSALATSALNLDKDIHREATVCSGHVISNTFLAVQHLARDSSFADLSHCLSGMVAIHANASYLADLRSVAFQPPLRALKFESGLEVPNLLVRYQVSTLPRALQLVFPAGVGKKDFIRNTVRVAFHGIDQRRKVVIFVAYGNLLVPMKELSTLVSKLDGSLVFKQEGDSFAIRLLAPAGQPVIVQLFESLQRLECMLSIFEFLRRKKLVIRSLSLSQVAFAYGPRRSLAAVMDIGMSKLSNSEQLDPVDILARTDPLLLLRLGIRFDHSNPHRRIQGSLAAILNHTSNKAALDSVAEILSFTLPAMRTLDQITSNLSRGEPARLQVVVRNAFTFLLHYINYALRFELTASQHAGRLTWVLRESGDPQVGPGQDQIRAKLRDTLYNSNGNGWKGLGNGVVADVEGVCSVISNLDTSFAGARDNQETSGDVKPTERSLNQTDVKNHRDHDFDAQAAMDYDTSAVATNSAGARSSQQCDAPPEAADVITID
Length1112
PositionTail
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Fumigati.
Aromaticity0.07
Grand average of hydropathy-0.168
Instability index44.34
Isoelectric point8.81
Molecular weight122897.64
Publications
PubMed=18404212

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31390
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     560.27|     191|     203|     212|     413|       1
---------------------------------------------------------------------------
  212-  380 (229.71/190.14)	............................................VA......NPDLKTALEVLSKGRVVSITDLGYEAPKQLTAKGALKR...LHkINRIISARLALHDtiPRPFRTYRVHDGRATFVVQ..GEFEL..DLSVGEESKSSQFFFVDIRFLFSPSSHVPKGRLSNELD.VQVNDRL.RDNGLKgCFDFLHGLVLTNKitILFKQAVElARGLWSDVLRV
  381-  585 (265.67/204.37)	ELLHRTLvvqYWAlKLGAKSWIEIGIKS..GRK...PHdvkdsgV........PYL..ALRWIRDGQEVDSTSVEFDA.DDLSMERLLRSiiaLH.ISHLLSATYSILN..QRSLFATGLLSLQALLNTNepGKCQLlaQLTVSRHLRVSIEPMSGAIVLSADPSPLDRSESDSSLEkSSVDDIVsRVSRLR.CIAALEEAESTVK..ILGFETVS.PRGLKADVRKI
  589-  682 (64.89/38.05)	NILRFAL...FWH.PFWDRSWIVAATSStdGDSwwvIHlrrpsaLAtsalnlDKDIHREATVCS.GHVISNT...FLAVQHLARDSSFAD...L...SHCLSGMVAIH........................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.81|      19|     932|      59|      78|       3
---------------------------------------------------------------------------
   59-   78 (31.94/25.46)	GPGQ.HIETHTgKDGINESEG
  993- 1012 (30.88/18.93)	GPGQdQIRAKL.RDTLYNSNG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31390 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ARDNQETSGDVKPTERSLNQTDVKNHRDHDFDAQAAMDYDTSAVATNSAGARSSQQCDAPPEAADVITID
2) MPGVVMDNATVGGPRRASESPDNVSSTPFPQERVNQSGDSGDRRNRSIFHNGAVKGAQGPGQHIETHTGKDGINESEGLP
3) QVSPHGQMPSTPANGKAPGDQSPENLQKKTR
1043
1
118
1112
80
148










Molecular Recognition Features






MoRF SequenceStartStop




NANANA