<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31389
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MTIAVKESKILYGNFDKAKSGIMKGSGGIVEQGPGLQQRIITPAKEMPPEIPHVEFNQLPLSVLIRNLTVYAAKELSQYMKTNVRSTQDASTRKMEFLRLIIFLRNQFLRLYVLVKWCKTIRQNNFHTMIDLLNWFRGTNIIVNNCLLALKDMSTSMAGAKLPNPDLITALEVLMLGRPDLPTHGFLLTGDENGQQANKIPAKLILKRFRDLNTCLSVKISLMDLPAEMHTYSIKDGRITFTVFPEFEISLSTIDRESPLFFVDVKFLFNENKFPLNTTKIALLVNDILYKSPTPLLSLYQFLHRYVLTLQLYMIHVELQDIETNGKYSGGNLAHHYDPKKNIISLRYWLQSKMNSKCKALIGVEKTSQSIILQWHLPDTKEEGKTTKYNNLLGNIEAILDEITFNHARIIMSELLDTGLFEGDDNKNDTSDTLFFHVPVICVATAPVQLKINTISGIFYFKNPSALLLSYAKQLNQTSDLDDVVNILERLRMDKIVHILRNMFEKTGWICEDVVKLNKPILYDKHKDKKRILTRDLFIRIKDWPANWFFILNLVASGATCIVEKLIGKVQSVKGTWEVKYLDQGNLQVSKLESITYQNVMHMQKTIIQKILNHMIIDSLNELKISKVICQGEASQKLPAYVQTNTAGASNVSIIAIGLESFLQGSKALSDTLESTIFLKMDYEQNEVKLFGKFKKDTQMIRYQCDDLLINFIDKRGLAFHMTEDFTSLNHVVQYLTKFRQKLMQLVVLTDVTEKLHNNFRSEHFQIVKLRPNEISFRYLKNSKDDQDCTIQIVTNETKIEKLQVQLSPLNPQNIIQKYLECDKYDPHFIFNYLHFTSKLFSAVKSIESITNTNTMTITLHLHTLAAYQLSYHDRLTGGQIALCIDLRNSPSRAGSMYHLYFAQEDYSASKNPMYPAILQVINNVFMLNNNTKRKVPSVIRLGTGVACPLGDIEPLLEEIHSILIRS |
Length | 967 |
Position | Tail |
Organism | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Eremothecium.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.130 |
Instability index | 39.71 |
Isoelectric point | 8.91 |
Molecular weight | 110809.63 |
Publications | PubMed=15001715
PubMed=23749448
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | RNA polymerase II repressing transcription factor binding GO:0001103 IEA:EnsemblFungi
TFIIB-class transcription factor binding GO:0001093 IEA:EnsemblFungi
transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP31389
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 292.95| 101| 191| 400| 513| 2
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400- 513 (146.36/140.40) LDEITFNH....ARIIMSELLDTGLFegdDNKNDTSDTlffhvPVICVATA....PVQLKINTiSGIfyfKNPSALLLSYAKQLNQTSDLDDVVNILERLRMDKIVHILRnMFEK....TGWI...CED
592- 707 (146.59/101.54) LESITYQNvmhmQKTIIQKILNHMII...DSLNELKIS.....KVICQGEAsqklPAYVQTNT.AGA...SNVSIIAIGLESFLQGSKALSDTLESTIFLKMDYEQNEVK.LFGKfkkdTQMIryqCDD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 201.45| 65| 555| 264| 337| 3
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264- 337 (97.61/94.16) DVKFLFNENKFplnTTKIALLVNDILYKSPTPLLSLYQFLHryvlTLQLYmiHVELQDIETNGKYS...........GGNLAHHY
826- 901 (103.85/73.47) DPHFIFNYLHF...TSKLFSAVKSIESITNTNTMTITLHLH....TLAAY..QLSYHDRLTGGQIAlcidlrnspsrAGSMYHLY
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