<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31388

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSALVGRAAEESFLSFKELVDKSKSTELSDTEKKVSLLKYVAKTQQRMLRLNALAKWCKQVPLINYFQDLGSTLSAHDICFTQAADSLFFMHEGLQQARAPVYDVPSAVEILLTGSYQRLPKCLDDVGMQSSLDEHQQKPALRKLEVLVRSKLLEITLPKEITEVKISKGTVTLSVDGEFKVLVTLGYRGHLSMWRILHLDLLVGERSGPIKLEVTRRHILGDDLERRMSVAENPFTILYAVLHELCVAIVMDTVIRQVRALLQGRWKDAIRFDLISDTGTTPANQEGEADSVSLRTPGMKLFYWSDSDKNSGPFIKIEPGSDLQIKCSHSTFVIDPLTGKEAEFSLDQSCIDVEKLLLKAICCNRYTRLLEIQKELLRNTRICRTPSDVILQALLDEPGIEGDNMVDSKERVEPEVLRVRAYGSSFFTLGINIRTGRFLLQSSKSILTSSILEEFEDALNQGSISAVDAFINLRSKSILHFFAAIGKFLGLEVYEHGFGINKVPKSLLDGSSILTLGFPDCESSHLLLMELEKDFTPLFKLLETQMDGSGKPQSFNDPSNILRAKKIDIGQIRILEDDLNLITSDVVKFVSSFSDAEGINQASGHRQPGLVDEALTEMSGSQLSFSSVVDGVFGLQKVTSALMSIDGHGLVPKNLSAVTGHGKAPMLTSYHSDSLYNRQGPLQSSSYNMLSSPPGKGSAMKKIAISNSDQELSLILSPSLSTGNGVSESGSRLVTESSLSPLPLSQTADLATSSAGPLLRKDQKPRKRSASDLLRLIPSLQVVEGVASPNKRRKTSELVQSELVKSWSPASQTLSTAVSTSTKTIGCSYGNLIAEANKGNAPSSVFVYALLHVVRHSSLSIKHAKLTSQMEALDIQYVEEMGLRDAFSDIWFRLPFAQNDSWQHICLQLGRPGSMCWDVKINDQHFRDLWELQKGSKTTPWGSGVHIANSSDVDSHIRYDPEGVVLSYQSVEADSIKKLVADIQRLSNARMFSLGMRKLLGIKPDEKTEECSANSTMKGSTGGKGSGEPVDRWRAFKIEAVGLTSLWFSFGSGVLARFVVEWESGKDGCTMHVSPDQLWPHTKFLEDFINGAEVESLLDCIRLTAGPLHALAAATRPARASTATGMPVVPATASSRQSNQIQQTQGIIAPSTLAAPNATGQSASATSGNTVASSAPSPLGGGFHGVAMLAAAGRSGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPKGGASIGGSLPCPQFRPFIMEHVAQELNGLEPNLTGSQGATNPNSGNPTVNGVNRVNFSPSSARAAMNRVASVASGSLVVSSGLPVRRTPGTAVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLREILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVRRFHHQAQQNGSSAAAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLSQSQQAGEIAPAQRPRIELCLENHSGTDLDNNCAAKSNIHYDRPHNTVDFALTVVLDPVHIPHINAAGGAAWLPYCVSVRLRYTFGENPSVTFLGMEGSHGGRACWQRVDDWEKCKQRVSRTVEVNGSAAGDLTQGKLKLVADSVQRTLHLCLQGLREGGNNNNNTHQKEFTI
Length1703
PositionTail
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.07
Grand average of hydropathy-0.133
Instability index44.17
Isoelectric point7.10
Molecular weight185506.49
Publications
PubMed=12426376
PubMed=11130713
PubMed=27862469
PubMed=17560376
PubMed=17526732
PubMed=22021418

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Involved in defining the duration of cell proliferation. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IDA:UniProtKB
plasmodesma	GO:0009506	IDA:TAIR

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
cold acclimation	GO:0009631	IMTAIR
multicellular organism development	GO:0007275	IEA:UniProtKB-KW
positive regulation of cell population proliferation	GO:0008284	IMTAIR
regulation of growth	GO:0040008	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
systemic acquired resistance	GO:0009627	IETAIR









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31388
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.34|      54|      82|     650|     705|       1
---------------------------------------------------------------------------
  652-  705 (95.52/45.37)	ALMSIDGHGLVPK.NLSAVTGHGKAPMLTSYHSDSLYNRQGPLQSSSYNMLSSPP
  735-  789 (82.82/41.28)	NGVSESGSRLVTEsSLSPLPLSQTADLATSSAGPLLRKDQKPRKRSASDLLRLIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     291.47|      87|     588|     954|    1048|       2
---------------------------------------------------------------------------
  954- 1048 (139.76/94.62)	SGVHIANSSDVDSHIRYD.PEGVVLSYQSVEADSIKklVADIQRLSNARMF....SLGMRKLLGIKPDekteecSANSTMKGSTGGKGSGEPVDRWRAFK
 1555- 1646 (151.71/86.20)	SGTDLDNNCAAKSNIHYDrPHNTVDFALTVVLDPVH..IPHINAAGGAAWLpycvSVRLRYTFGENPS......VTFLGMEGSHGGRACWQRVDDWEKCK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     277.49|      90|     588|     245|     342|       3
---------------------------------------------------------------------------
  245-  342 (136.54/105.41)	PFTI.LYAVLHEL...CVAIVMDTVIRQVRAL.LQGRWKDAIRfDLISDTG.TTPANQEGEADSVSLR..TPGMklFYWsDSDKNSGPFIKIepgSDLQiKCSHST
  853-  950 (140.95/83.49)	PSSVfVYALLHVVrhsSLSIKHAKLTSQMEALdIQYVEEMGLR.DAFSDIWfRLPFAQNDSWQHICLQlgRPGS..MCW.DVKINDQHFRDL...WELQ.KGSKTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.75|      42|     453|    1052|    1098|       4
---------------------------------------------------------------------------
 1052- 1098 (69.43/58.95)	VGLTSLWFSfgsgVLARF..VVEWESG..KDGCTMHVSPDQlWPHTKF.LED
 1507- 1553 (57.33/34.86)	ITLLTLPIS....VLREFlkLIAWKKGlsQSQQAGEIAPAQ.RPRIELcLEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.96|      14|     588|     613|     626|       6
---------------------------------------------------------------------------
  613-  626 (25.56/15.90)	ASGHRQPGLVDEAL
 1202- 1215 (25.41/15.76)	AAGRSGPGIVPSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.42|      18|     453|     717|     734|       7
---------------------------------------------------------------------------
  717-  734 (30.08/15.87)	SNSDQELSLILS..PS.L.....STG
 1149- 1171 (24.04/11.20)	SNQIQQTQGIIA..PS.TlaapnATG
 1173- 1193 (19.29/ 7.51)	SASATSGNTVASsaPSpL.....GGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.10|      29|     133|    1112|    1141|       8
---------------------------------------------------------------------------
 1112- 1141 (47.18/34.19)	IRLTAGPLHALAAATRP.ARASTATGMPvVP
 1242- 1271 (54.92/35.67)	MRCFAGDQVWLQPATPPkGGASIGGSLP.CP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.11|      55|      86|     434|     489|      11
---------------------------------------------------------------------------
  434-  489 (85.79/56.17)	GSSFFTLGI.NIRTGRFLLQSSKSILTS..SILEEFEDALNQGSiSAVDAFINLRSKSI
  521-  578 (86.33/52.36)	GSSILTLGFpDCESSHLLLMELEKDFTPlfKLLETQMDGSGKPQ.SFNDPSNILRAKKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.14|      41|    1234|      94|     138|      13
---------------------------------------------------------------------------
   94-  138 (62.92/45.94)	AADSLfFMHEGLQQARAPVYDVPSAVEILLTGSYQRLPkclDDVG
 1332- 1372 (71.22/39.44)	ASGSL.VVSSGLPVRRTPGTAVPAHVRGELNTAIIGLG...DDGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31388 with Med14 domain of Kingdom Viridiplantae
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