<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31387

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPQPLEQGGAVTSFIPTGQEMAQRQNLIPLGRLIDFIIQRTYHELTVLAELLPRKTDMDRKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMGFLDKQSMLFIDTADMLSRVARETLVHARLPNFHIPAAVEILTTGSYSRLPSVIRDRIVPPDPITPAEKRQTLQRLNQVIQHRLVTGSLLPQLRKFRIENGRVTFKVDHEFEVSLTVMGDAPTVPWRLLDIDFLVEDKETGDGKALVHPLQVNYIHQLIQGRIVDCTDALAEVYTCLHYFCQSLQLEVLYTQTLRLIRDRLDDHIHVDEYVVGSRLTVSYWRELTNKDPKSELGYRLTIQTDPNDAAKQLAILHVPSIGNKEADIADRAVRSDLLSMERLLVHTVYVRSLARLNDVKTELQLFLKDVEYNIQGTPAMLTVPVLNPCLRAEHIYITVDTHTGMLRCHVPKHLDCPIMPEMQHALNNDWSKLQHLISELRYWITQRRCEKTLQHLPAATQDRLPLIYSHTHPIARMGPHKVFIQLYRHANVILIVELKEKKTCPNEMTYTFYLVLVKPSSVEEGQSPDVLSGQPPQPSAAGGPAPGSDSANAAMPKMYLRVLSMIEFDTFVATHGPGTYIDDPSPTSTSGTSVKRKVSPLDNALSAIGPPLKQQKTIYPAYFIPELAHVVAMCDEKLPFVTLAKEFSMRKIPHGGLQVEANATSLVLKLLTLPQPKPPQAPPTPQQQQQQQQQQQQPGTSDAKSSGAGASANEPKTVHVPPIDKQVWNALLKRLLSVSVRAQVNKSNQTRLWTMELVFYGSPLPSLHHKEQGMRRAVYLQYEMQPVESVSKVVDQLLSDWSKIVYLYTLVHEFREQYNNEKYNLPSMVAIKSYSYTNLLLAYGPNKDVSVNICWDTEAKEFRLVFTGGNSAINAHSMMRDQLQAHLNHNYSLAQVVHMLHETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEVRFRGGGLCTIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVFRRRSQSEDDNPPSPVTLEDPSAGAGNNGGGGGGGGGAGGGANTFLSGGTGMRGPQSPRDPGLRFAAPLTPPTSSNPHTPASPHPIGGGGGAGGAGGQGGQGGQGGQQQSHMNNFNMTSPPASHMPHPSPGGGLMPSSPLNAQPSPMAAHSPGPSSLSYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYTSRVLPARSWAGAIPTTLTYEALDTLCRATPHPQKEVPGPELSPLERFLGSVFMRRQLQRIIHQEESLMAITSNEPGVVVFKADCLQYQVFLNPNHMQSLHLKVDQLPMGPMMDGKPPYQWAAQDLQILEQFFDHRVAAPPYRPAVMTSFTRMLNLPAKVLKDFIQIMRLDLMPELVQGNKWNVQFVLRVPPSATPIVPVGTTTILSHRQKILFFIQITRVPYLPNMEWKDAVTMLLPMVYDMNMNHTTLAERREPMPPQLTSAVSAHLRRFSECSVLLPDECSLFPAVHDLLLTLTLPNEPPAPGQMQMQLGGVMQPGGGPGVPGGPGGPMGGQIGGPTPQVVPQVGSSPSPMMHSPMQQMGGGGPQPGAYGGMVGGPGGGPQSGGPVGGGPGGPN
Length1639
PositionTail
OrganismAnopheles gambiae (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy-0.280
Instability index52.80
Isoelectric point8.55
Molecular weight180125.82
Publications
PubMed=12364791

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31387
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     434.82|      59|      63|    1511|    1573|       1
---------------------------------------------------------------------------
 1048- 1095 (42.14/10.10)	.................PPS......PVTLEDPSAGAGNNGGGG..GGG..GG..AGGGantfL....SGGTGmrGPqSP.......R.
 1096- 1146 (60.48/17.47)	......DPGLRFAAPLTPPTssnphtP.ASPHPIGG....GGGA..GGA..GG..QGG..........QGGQG..GQ.QQ.......S.
 1147- 1187 (53.30/14.58)	..HM...NNFNMT....SP.......PASHM........PHPSP..G....GGlmPSSP....L....NAQ.....P.SP....maaHS
 1188- 1222 (47.17/11.48)	PGPSSLSYMQSH..TDGSP..........FA.....ALSPAAS...NWP..GS..PGMP..............................
 1478- 1526 (60.72/22.92)	LLPMVYDMNMNHTTLAERRE......P..MPPQLTSAV....S..............AH....LrrfsECSVL..LP.DE.......CS
 1527- 1592 (103.78/34.85)	LFPAVHDLLLTLTLPNEPPA......PGQMQMQLGGVMQPGGGP..GVP..GG..PGGP....M....GGQIG..GP.TPqvvpqvgSS
 1593- 1638 (67.25/19.54)	PSPMMHSPMQQM..GGGGPQ......PGAYGGMVGG...PGGGPqsGGPvgGG..PGGP..............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     565.48|     184|     564|     661|     867|       2
---------------------------------------------------------------------------
  661-  867 (265.50/222.97)	PElaHVVAMCDEKLPFVTLAKEFSmRKIPhGGLQVEAnatslvLKLLTLPQPKPPQAPPTPQQQQQQQ......QQQQQPGTSDAKSSGAGASANEPKTVhVPPIDKQVWNALLKRLLSVSVRAQVnksNQTRLWTMelvFYGSPlP......SLHHKEQGM.RRAVYLQYEMQPVESVSKVV...dQLLSDWSKIVYLyTLVHEFrEQYNneKYNL.......PSMVAI
 1232- 1439 (299.98/182.09)	PE..HKVQTSHHYTSRVLPARSWA.GAIP.TTLTYEA......LDTLCRATPHPQKEVPGPELSPLERflgsvfMRRQLQRIIHQEESLMAITSNEPGVV.VFKADCLQYQVFLNPNHMQSLHLKV...DQLPMGPM...MDGKP.PyqwaaqDLQILEQFFdHRVAAPPYRPAVMTSFTRMLnlpaKVLKDFIQIMRL.DLMPEL.VQGN..KWNVqfvlrvpPSATPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     174.07|      46|     163|       3|      48|       3
---------------------------------------------------------------------------
    3-   48 (78.92/47.24)	PQPLEQGGAVTSFIPTGQEMAQ..RQNLIP...LGRLIDFIIQR...TY...HELTV
  109-  143 (38.56/19.02)	............FIDTADMLSRvaRETLVH....ARLPNFHIPA...AV...EILTT
  160-  212 (56.59/31.63)	PDPITPAEKRQTLQRLNQVIQH..R..LVTgslLPQLRKFRIENgrvTFkvdHEFEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.46|      15|      30|     414|     428|       4
---------------------------------------------------------------------------
  414-  428 (27.13/12.99)	PAMLTVPVLNPCLRA
  447-  461 (30.32/15.37)	PKHLDCPIMPEMQHA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.39|      16|      39|     249|     264|       6
---------------------------------------------------------------------------
  249-  264 (28.66/20.43)	LQVNYIH..QLIQGRIVD
  285-  302 (22.73/14.56)	LEVLYTQtlRLIRDRLDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31387 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FRRRSQSEDDNPPSPVTLEDPSAGAGNNGGGGGGGGGAGGGANTFLSGGTGMRGPQSPRDPGLRFAAPLTPPTSSNPHTPASPHPIGGGGGAGGAGGQGGQGGQGGQQQSHMNNFNMTSPPASHMPHPSPGGGLMPSSPLNAQPSPMAAHSPGPSSLSYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYTS
2) LLTLPQPKPPQAPPTPQQQQQQQQQQQQPGTSDAKSSGAGASANEPKTVH
3) LTLPNEPPAPGQMQMQLGGVMQPGGGPGVPGGPGGPMGGQIGGPTPQVVPQVGSSPSPMMHSPMQQMGGGGPQPGAYGGMVGGPGGGPQSGGPVGGGPGGPN
1037
706
1538
1244
755
1639










Molecular Recognition Features






MoRF SequenceStartStop




NANANA