<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31386

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTPQPLEQGGAVASFIPTGQEMAQRQNLIPLGRLIDFIIQRTYHELTVLAELLPRKTDMERKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMAFLDKQSLLFMDTADMLSRMARETLVNARLPNFHIPAAVEILTTGTYSRLPSIIRERIVPPDPITTLEKRQTLQRLNQVIQHRLVTGNLLPQLRKFKIENGRVTFKVDHEFEVSLTVMGDGPNIPWRLLDIDILVEDKETGDGKALVHTLQVNYIHQLIQGRIVDSPDALAEVYNCLHYFCQSLQLEVLYTQTLRLMRDRLDDHIHVDEYIPGTKLTVSYWRELTNKDPKSELGYRLMIQTDQSDTTKQLAILHLPSIGTKEVDIADRAVRSELLSMERLLVHTVYVRSLARLGDLKTELQLFLKDVDYSIQGTPAMLLVPVLNPCLRAEHIYITVDTHTGMLRCHVPKHLDCPIMPELQHALNNDRSKLQHLFSELRYWITQRRCEKTLQHLPATTQERLPLVFPADHPIEKIGPHRVYIQMCRHANVILIVELKEKESSPNEMTYTFYLVLVKPSSMEDSQSVTAGGTSQSSAPSAATTESDGMPKMYLKVLSLIEFDTFVATHGPGTYVDEQTVGSKRKLLTGEGPSAKQSKTIYPAYFIPELAHVVAMCDEKLPFVALAKDLTRRKIPHGGVQVEANATSLVLKLLTLPQPKPPVIPVSSSAAAAAAAQSGPDQKPPEPKVVSVPKIDKDVWNALLKRLLSVSVRAQINKSIQTRMWTVELVFYGTPLASAHHKEQGMRRAVYLTYDMLPVDSVDKFVDMILNDWSKIVYLYTLVHDFREQIKNDKYNLHNIVTIKSYSYTSLLLAYGPNKEVNVNIYWDTEAKEFKMVFTGGNNAINAHSMMRDQLQAHLNHNYDLAQIVYLLHETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEVRLRGSGLCSIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVYRRRSQSEDDNPPSPITMEDPHGGPASVGSTFLSGGAMRGPQSPRDPGLRFAAPLTPPSGSNPHTPASPHPQGIGGSQSHPNFNMTSPPAPHMPHPSPSGGLMPSSPLNPQPSPMAAHSPGPTNLPYMSGHTDSPFSAHSPAASNWPGSPGMPRPSPRPGQSPDHKAQKRLLIISLKFTAPHHNTSRVLPARSWAGAIPTLLTHEALDTLCRATIHPQKEIPGPELSPLERFLGSVFMRRQLQRIIHQEDNLTAITSNEPGVVLFKADNLQYQVFLNPNHMQSLHMKVSQAPMAPTMDGKPPYQWPPEDLQILEQFFDQRVAAPPYRPAVVTSFTRMLNLPSQVMKDFIQIMRLDLIPELGQGNKWNVQFILRMPPSATPIVPVGTTTILSHRQKILFFIQITRVPYLPNMELKDSVTMLLPMVYDMTVNHTQLAERREQIIPQLTSAVSAHLRRFVECTVLQPGECSLFPAVRDLLMNLTLPNEQPPPGQMGNQIGTMGGMAPGGPGGPGPMGGQIAPSPVGGQVVSSPNPMMHSPMQMGGGGQQSNYGGMVGGGAQSGVPGGPGAGGPN
Length1578
PositionTail
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Aedini> Aedes> Stegomyia.
Aromaticity0.07
Grand average of hydropathy-0.244
Instability index51.59
Isoelectric point8.65
Molecular weight175325.26
Publications
PubMed=17510324

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31386
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      96.40|      11|      15|    1095|    1105|       1
---------------------------------------------------------------------------
 1070- 1080 (21.61/ 6.66)	PHTPASPHPQG
 1095- 1105 (26.48/10.17)	PPAPHMPHPSP
 1111- 1121 (22.62/ 7.39)	PSSPLNPQPSP
 1154- 1164 (25.69/ 9.59)	PGSPGMPRPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.94|      25|      66|     822|     846|       2
---------------------------------------------------------------------------
  822-  846 (43.57/37.39)	REQIK...NDKYNLHNIVTIKSYSYTSL
  887-  914 (40.38/33.98)	RDQLQahlNHNYDLAQIVYLLHETYQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.57|      24|      65|    1342|    1365|       3
---------------------------------------------------------------------------
 1342- 1365 (43.27/25.14)	TRMLNLPS.................QVMKDFIQIMRLDLIP
 1376- 1416 (34.30/18.40)	QFILRMPPsatpivpvgtttilshrQKILFFIQITRVPYLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.51|      19|      65|     605|     628|       4
---------------------------------------------------------------------------
  610-  628 (33.27/26.12)	YVDEQTVGSKRKLLTGEGP
 1001- 1019 (34.24/14.02)	YVDETAVYRRRSQSEDDNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     175.39|      49|      65|     284|     332|       5
---------------------------------------------------------------------------
  214-  269 (31.50/18.65)	.........LTVMGDgpnipwRlLDIDILVEDKETGdgkalvHTLQV..NYIHQLIQgriVDSPDAL
  284-  332 (84.68/65.08)	QLEVLYTQTLRLMRD......R.LDDHIHVDEYIPG......TKLTV..SYWRELTN...KDPKSEL
  348-  399 (59.22/42.85)	QLAILHLPSIGTKEV......D.IADRAVRSELLSM......ERLLVhtVYVRSLAR..lGDLKTEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     130.81|      19|      20|    1490|    1508|       6
---------------------------------------------------------------------------
 1026- 1044 (27.81/ 9.10)	EDP.HGGPASV..GSTF..LSGGA
 1490- 1508 (37.65/14.89)	PNE.QPPPGQM..GNQI..GTMGG
 1511- 1531 (35.86/13.84)	PGG.PGGPGPM..GGQIapSPVGG
 1537- 1558 (29.50/10.09)	PNPmMHSPMQMggGGQQ..SNYGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.59|      10|      20|    1122|    1131|       9
---------------------------------------------------------------------------
 1122- 1131 (20.66/10.37)	MAAHSPGPTN
 1143- 1152 (18.93/ 8.87)	FSAHSPAASN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.09|      13|      62|    1166|    1179|      11
---------------------------------------------------------------------------
 1166- 1178 (23.25/16.44)	PGQSPDHKAQKRL
 1184- 1196 (22.84/ 9.88)	KFTAPHHNTSRVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.56|      13|      46|    1427|    1439|      15
---------------------------------------------------------------------------
 1427- 1439 (23.62/15.25)	LLPMVYDMTVNHT
 1476- 1488 (20.93/12.55)	LFPAVRDLLMNLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.51|      23|     184|     453|     509|      16
---------------------------------------------------------------------------
  478-  506 (37.88/75.26)	YWITQrrcektLQHLPATTQERLPLVFPA
  640-  662 (42.63/ 9.70)	YFIPE......LAHVVAMCDEKLPFVALA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31386 with Med14 domain of Kingdom Metazoa
Unable to open file!