<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31384

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSASFVPNGASLEDCHCNLFCLADLTGIKWKKYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPSFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSPVGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSVQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLCEEATAAKVASWDFVEATQRTNCSCLRHKNLKSRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDADSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPPQYQEAVEPTVYVGTAVNLEEDEANIAWKYYKFPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQCLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGSDDKASCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKTLPSQYLPPIKLPEECIYRQSWTVGKLELLSSGPSMPFIKEGDGSNMDQEYGTAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDCGKEAEKRFEALRATSAEHVNGGLKESEKLSDDLILLLQDQCTNLFSPFGAADQDPFPKSGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPVSRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLASAASSTMTVTSGVAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSALQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAVTYPPAIVVYIIDPFTYENTDESTNSSSVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDREIYPQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKSSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQSTDRLLSTEPHEEVPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQLYNFIMNML
Length2174
PositionMiddle
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.08
Grand average of hydropathy-0.396
Instability index53.01
Isoelectric point5.40
Molecular weight239294.28
Publications
PubMed=10198638
PubMed=16625196
PubMed=15489334
PubMed=9628581
PubMed=10235266
PubMed=10235267
PubMed=15175163
PubMed=15989967
PubMed=16595664
PubMed=18691976
PubMed=18669648
PubMed=19369195
PubMed=19690332
PubMed=23186163
PubMed=24275569
PubMed=29740699

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IDA:UniProtKB
membrane	GO:0016020	HDA:UniProtKB
nucleoplasm	GO:0005654	IDA:HPA
nucleus	GO:0005634	IDA:UniProtKB

GO - Biological Function
nuclear receptor coactivator activity	GO:0030374	NAS:UniProtKB
thyroid hormone receptor binding	GO:0046966	IDA:UniProtKB
transcription coactivator activity	GO:0003713	IDA:UniProtKB
transcription coregulator activity	GO:0003712	IDA:UniProtKB
vitamin D receptor binding	GO:0042809	NAS:UniProtKB

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IDA:MGI
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IDA:UniProtKB
positive regulation of transcription, DNA-templated	GO:0045893	IDA:UniProtKB
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	TAS:Reactome









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31384
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.07|      26|      28|    1098|    1125|       1
---------------------------------------------------------------------------
 1100- 1125 (49.62/36.59)	MNIK.GADVGVYIPDPTQEAQYRCTCG
 1130- 1156 (42.45/22.65)	MNRKfGNNSGLFLEDELDIIGRNTDCG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     210.86|      35|      57|     955|    1007|       2
---------------------------------------------------------------------------
  516-  555 (47.77/11.72)	.VAKTPQMHGTemansPQPPPLSPHPCDvVDEGVTKT..PSTP
  973- 1007 (64.89/41.04)	GTAYTPQTHTS.....FGMPPSSAPPSN.SGAGILPS..PSTP
 1033- 1066 (51.31/13.63)	SVKYENSDLYS.....PASTPSTCRPLN.S...VEPAtvPSIP
 1525- 1559 (46.88/11.25)	SVATANSTLTT.....ASTSSSSSSNLN.S..GVSSNklPSFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.45|      41|     534|    1222|    1310|       3
---------------------------------------------------------------------------
  767-  811 (64.60/17.62)	STSLIYDSDLAVSYTD..LDNLFNSDEDE.......LTPGSKKsangSDDKASC
 1225- 1274 (68.85/96.57)	ERDCCNDCYLALEHGRqfMDNMSGGKVDEalvksscLHPWSKR....NDVSMQC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     338.00|     104|     534|      35|     148|       4
---------------------------------------------------------------------------
   35-  148 (176.04/141.93)	WQGPTSAPILFPVTEEDPI..LS.SFSRCLKADV.....LGV...WRRDQRPGRRELWIFWWGEDPSF.ADLIHHDlSEEEDGVWENGlsYECRTllfkAVHNLLERClmnRNFVRIGKWFVKPYE
  561-  676 (161.97/105.46)	YQMPTPDPLVPSKPMEDRIdsLSqSFPPQYQEAVeptvyVGTavnLEEDEANIAWKYYKFPKKKDVEFlPPQLPSD.KFKDDPVGPFG..QESVT....SVTELMVQC...KKPLKVSDELVQQYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.13|      48|     534|     284|     361|       5
---------------------------------------------------------------------------
  284-  340 (73.52/72.59)	LVPQSdiPTPSPVGSThcsssclGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQ
 2014- 2061 (87.60/34.41)	ILPAS..PTGSPVHSP.......GSHYPHGGDAGKGQSTDRLLSTEPHEEVPNILQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.16|      19|     533|    1292|    1310|       6
---------------------------------------------------------------------------
 1292- 1310 (36.99/24.55)	AIQKKRTVRPWGVQGPLTW
 1828- 1846 (35.17/22.92)	ARRKKSSARKFGLQKLWEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     234.31|      75|     254|     426|     507|       7
---------------------------------------------------------------------------
  426-  507 (118.51/88.03)	CLrhknlkSRNAGQQGQAPSL.......GQQQQILPKHKTNEKQEKsEKPQKRPLTPFHHRVSV..SDDVGMDADSASQRLVISAPDSQVR
  681-  764 (115.79/70.30)	CL......SAIASDAEQEPKIdpyafveGDEEFLFPDKKDRQNSER.EAGKKHKVEDGTSSVTVlsHEEDAMSLFSPSIKQDAPRPTSHAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.08|      17|      26|     905|     929|       9
---------------------------------------------------------------------------
  824-  841 (26.37/21.54)	CISTADLhKMYPT...P....PSLE
  914-  937 (23.71/14.77)	CSMFAPL.KTLPSqylPpiklPEEC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.48|      56|     712|     849|     905|      10
---------------------------------------------------------------------------
  849-  905 (100.07/59.74)	PM.NMNNKEYGSMdTTPGGTV.................LEGNSSSIGAQFKIEVDEGFCS.PK...PSEIKDFSYVYKP
 1560- 1637 (78.41/41.88)	PFgSMNSNAAGSM.STQANTVqsgqlggqqtsalqtagISGESSSLPTQPHPDVSESTMDrDKvgiPTDGDSHAVTYPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.26|      42|    1220|     167|     236|      11
---------------------------------------------------------------------------
  167-  236 (61.65/98.18)	FLHGDSNVCTSVEINQHQPV.YLlseehitlaqqsnspfqvilcpfglngtLTGQAFKMSDSATK....KLIGEW
 1388- 1434 (65.61/44.88)	FFRDLTAIYESCRLGQHRPVsRL............................LTDGIMRVGSTASKklseKLVAEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.85|      17|     712|     943|     961|      12
---------------------------------------------------------------------------
  943-  961 (28.40/23.02)	WTVGKL....ELLSSGPsmPFIK
 1662- 1682 (28.45/15.72)	WTLGLLrcflEMVQTLP..PHIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.13|      22|      24|    1328|    1349|      15
---------------------------------------------------------------------------
 1328- 1349 (42.16/21.14)	P..EPLPIPTFLLGYDYDYLVLSP
 1353- 1376 (36.97/17.69)	PywERLMLEPYGSQRDIAYVVLCP
---------------------------------------------------------------------------











Associated diseases
Disease
breast cancer	PMID:26452386



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31384 with Med13 domain of Kingdom Metazoa
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