<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31382

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSAKDSDKDASRKMKLQKRPEWNNGGSLEDCISNVYALLELPGIKWKCYRTKPNAPRGVALTADFVLKAYSKCLLDGILCTWRRKPLPPTDNKETPKLTNFSNDAPKELWVFWYDDEPALLQKNCEGLDNDDELSSANQMNIVSYEVRTIIFKALHVVLERDLTKDGFVRFGRWFTVPYDARENYLHFTYPSHSPAIRFNFFVHGSSTICASVQAQRQPTLITLARRHLECKTKRVVVVVGPWSMRGQLVQDQIALLADPKIQESAEKEWNQWKDYLQMEEKEPENVSEERQKSPDSDPPAPPQTTRVLLADSSDEEQSQSFEAIDESKKDDIPQRLRWMYEPDYRQEKSKEETPEEKEKREQSREVRKQRRKLREERRKEVERQRTEVKNPDDYDSDVVTDEDVGEKEECVNNDVPKMVLLDIDGVRLLYPSKFLCVTIDEDRQMLESIGLKTNQQPPELQAQNRRPRNKLVVNVANPILSTMAVYQYCENERLISKENVPQKSATSGQLLPPLKEKFLNWKFTAKKYGCRGDVSCRHCAEAEYQGESDGQVILDVDRHNRFLKYGPYTENSIRWHKIRSRIQKKFDFHAYHKKHPIGPITPRKAGDSVKQTKQLSAVKRRRRARRERAQKKRRDKKRPTGSTRADSEDDSFRMDKLSQDDWANFEGEHPKGIPEIEVDKDFELHNDIKIPKVPNDDNYKPKSFLPITYLTNNVDNNDFESMPGDDDMSEERFNQIFKDKYNRWKPGMSRAEKIEHAHYQFDPSNQMTGSPREYHLKDLPKKIQKYESILPTPKGNKFFKGSICRKGLRGYDEICADQDEKEMMRKAKWLKKARRKVSKQQIKKAGQYHIDMQKQIVKRSLKRAIRKLKLTTKKDSQSKGTKQQKLVLLSYKKKKVDEKKFQQYLKEVENVLDKLDVNSFCKKNEKAGFSEKAIPSGYIIPDYESSIHCGMEEESDSEIDEPRHGLGEGTCGQYLEGESVDLADMEHHHNELPMEVTSIGHIRTVGEHIGPDGMLSPPASNEMPKGGPLSVGPPSIESQGLNQIYPTPPSVQMLLGDAAQAHSPVMHTKSRYAMNTLEDDVERIAVPGGVGSLVEIEADDIETKNMQKWSKLSNQSKLSKFIALSCKDPFLKSKKKKYDTPVTSKFKIENEPPSMSAELVYAPMVTRNFYSAPHRTFGTLAQKVVDKRPSQFAIPSTSTAAHPGLTTPMASIFQSPTMPPPHTPSPFSAGPMSHHPMGPPAYPGTPGSFPPTTPTYPGMTPRPGPNFGPPGPVYPNSQQMMGPGGYPPQMGMINSQRHFQNQQMYQQQMVRMQQMRQMGGPPGYGAPGVSPYQQVNAITSPAGFGMPPNGPSSVQRLNNFVNQSQFGPNNGHPTPPYGYMQQMIPQSPNFNQQYNGMGNQLMSPIHQHQFHQQQMVQQQQQQQMQMHRQQMQMQNQNMSQPFQPPTAQMLQMQQNEQMRIAFSTLSERDKAKFQKRQGQLRSGIMPKSLQPAVLKNLKNPPDANIPYMKQDALFRPPESNSLQGESLTIAIVLSDTLLDLHFDSVFDACPICSCSVSIRSRDIGMYITPHTVLYSTERGHTNMREHTTGPWSGFNVNSATNCTCGFSAIRHRYLSCCSGLFEEDADEATASEHAVAPVIPPLDYPKKSTARDMSWFDSKSVHDLALLDQIRQMAFSNSLGKAVSHMATIKEHNRNLAIAVDLGNDVTVPSEYILSHVDALELLMLGNSVLGPMKNTSIANQVASHNKFLGFFHPWGIQIANGMTELEASEWVDLLGVVTPTLEGSMKQARHIPAETPFELDGPMTWKQIVTKSNRGKPPADDEEDFSLPEPVPAIMRALTKEAIRAAPNIEQYYEQAGLGPVDQPKDVMYITVIPDDDDIYSRTVEFMDTLTRTYEKMRLGRHIPFPVSTGTATRFREAFKSCQSQFPFQEQQHLAYTNQTLRNMPQTLADTPDPVNSDPKVWSRRAKRKLDFEEELKLPEAGSETIDESDDDEENEEVSKEENNELIDSEDVMDEVPKGFYEREGILRVGAPMEPSRSPHTVTNTPEFDNMTKYLSDENGFVSRLRLYLQQMEDLVHFALSENPEAFDRRGYRYQLAVEGRLKRQKHKMDIIEERLRFEASKDFDEQSDRKEPLEENDPEITPGIVISNNPVESWIDDELEEKRQQRQKENEQYPPEAQQAPSPVPAGMIHIPETLSKEERAVQPTLEMILADPATVAPINAQNIVWKQRDTRVPNPFPSSNQPPVAFEAAGSPDTDAYSTLPHVIVVYVVNPFSYGPEGHSALHMRIAILAFIRAFNSIMCKIPYEKRPQLQLEIVGMEGMDNVAKPIPDYFNDAKIPFDLLNDRPIRVERPGESVQGELARSLSIAVYTHPRVFFPDVYKSASARCMTAFGPGSQLMNTINKIEALNKDSFARMAKRSKTTLDTMDMYRHPGMIQAQQSTEKKNYIAYRVPSNIAVLAPPPMVYQMDEKGKAIMNQLDEQTLFISYCLVGTDFLVATATDAQGKLIDNCISNIKPRRQSNQVYRYRNKTQILDGMGKLWSFILGIMASETKNWRLVVGRLGRIGHGEFRAWTHLLNKTSLLRYSGSLKDICGACRSMPSVIGTPAILSACLITLEPEPSIRIMPEFHDQELSTKKSFLFQTPGDLSCTHILTFPVGTEINLEVQDQTADTKADENWEFGDLDIMEGLDDGDTEIMKDLGLETPSSAAIRQTGGPSMFFSEDSSSIEIQNQPLASGYYISTAPAPELPAWFWATCPSAKRHSPVHLKSSLHIHISEVKNDDIAMESTKEKEKDKEKDEKDAHPLESRQTEEVLRHVLESYNALSWLNLNRQTGDRYSCLPIHIQHLLRLYHSVARLLA
Length2862
PositionMiddle
OrganismCaenorhabditis elegans
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.08
Grand average of hydropathy-0.715
Instability index53.02
Isoelectric point6.33
Molecular weight325133.55
Publications
PubMed=15790964
PubMed=9851916
PubMed=15073178

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for asymmetric division of T-cells and for hypodermal development. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
multicellular organism development	GO:0007275	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31382
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     239.42|      33|      33|    1394|    1426|       1
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 1258- 1283 (40.79/20.09)	..YPG......MTP...................RPGPNFGP............PGPVYPNSQQMM
 1290- 1320 (50.52/27.12)	PQM.GMINsQ..RH...................FQNQQMYQ............QQMVRMQQMRQM
 1332- 1390 (25.90/ 9.33)	SPYQQV.N.AITSPagfgmppngpssvqrlnnfVNQSQFGPnnghptppygymQQMIPQS....P
 1394- 1426 (66.56/38.71)	QQYNGMGN.QLMSP...................IHQHQFHQ............QQMVQQQQQQQM
 1430- 1460 (55.65/30.82)	RQQMQMQN.QNMS.....................QPFQPPT............AQMLQMQQNEQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     164.51|      43|     166|     559|     606|       2
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  517-  551 (31.21/11.92)	..KEKFLnwkftakKYGCRGDVSCR.HCAEAEYQGESD.............
  559-  601 (82.71/54.67)	DRHNRFL.......KYGPYTENSIRWHKIRSRIQKKFDFHAYHKKHPIG.P
  645-  676 (50.58/22.37)	TRADS..............EDDSFRMDKL.....SQDDWANFEGEHPKGiP
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     328.24|     111|     167|    1856|    2022|       3
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 1856- 2004 (157.17/161.08)	YEQAGL....GPVDQPKDVMYITVIPDDDDI..Y.SRTVEFMDTLtRTY.EKMRLGRHipFPVSTGTatrfrEAFKSCQSQFPFQEQQHLaytnqtlrnmpqtladtpdpvnsdpkvwsRRAKRKLD.FEEELKLpEAGSETIDESDDDEENEEVSKE
 2024- 2143 (171.07/81.78)	YEREGIlrvgAPMEPSRSPHTVTNTPEFDNMtkYlSDENGFVSRL.RLYlQQMEDLVH..FALSENP.....EAFDRRGYRYQLAVEGRL.............................KRQKHKMDiIEERLRF.EASKDFDEQSDRKEPLEENDPE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     463.94|     158|     631|    1586|    1841|       4
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 1637- 1840 (236.47/293.57)	VAPVIPPLDY.PKKSTARDM.......swfdsksvhdlalldqirqmafsnslgkavshmatIKEHNRNLAIAVDLGND....VTVPSEYILSHV.DALELLMLGN.SVLGPMKNTSianqvAShNKFLGFFHPwGIQIANGMTELEA..SEWVDLLGVVTPTLEGSMKQARH...IPAETPFELDGPMTWKQIVTKSNRGKPPAddeeDFSLPEPVPAIMRA
 2270- 2481 (227.47/124.67)	VVYVVNPFSYgPEGHSALHMriailafirafnsimckipyekrpqlqleivgmegmdnvakpIPDYFNDAKIPFDLLNDrpirVERPGESVQGELaRSLSIAVYTHpRVFFPDVYKS.....AS.ARCMTAFGP.GSQLMNTINKIEAlnKDSFARMAKRSKTTLDTMDMYRHpgmIQAQQSTEKKNYIAYRVPSNIAVLAPPPM....VYQMDEKGKAIMNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.86|      23|      28|     811|     838|       5
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  811-  838 (34.32/34.64)	RGydeicADQDEKEMMRK..AKWLKKARRK
  845-  869 (34.54/20.62)	KK.....AGQYHIDMQKQivKRSLKRAIRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.67|      19|      19|    1210|    1228|       6
---------------------------------------------------------------------------
 1191- 1225 (28.36/11.13)	PSQfaipststaahpglttPMA..SIFQSPTMPPPHT
 1226- 1255 (24.32/ 8.37)	PSP.......fsagpmshhPMGppAYPGTPGSFPPTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.18|      26|      28|    1002|    1028|       7
---------------------------------------------------------------------------
  979-  997 (26.28/11.49)	........G.ESVDLADM..EHHHNELPME
 1002- 1028 (46.80/31.69)	G..HIRTVG.EHIGPDGMlSPPASNEMPKG
 1034- 1058 (30.09/14.41)	GppSIESQGlNQIYP....TPP.SVQMLLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     222.31|      66|     631|     252|     330|       8
---------------------------------------------------------------------------
  252-  318 (109.51/69.63)	QdQIALLADPKI.QESAEKEWNQWKD.YLQMEE..KEPENVSEERQKSPDS..DPPAPPQTTRVLLAD..S.SDEE
  336-  399 (74.18/55.98)	Q.RLRWMYEPDYrQEKSKEETPEEKEkREQSREvrKQRRKLREERRKEVER........QRTEVKNPDdyD.SD..
 2164- 2203 (38.62/14.61)	...............................EE..KRQQRQKENEQYPPE.aqQAPSPVPAGMIHIPE..TlSKEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.80|      15|      19|    1488|    1506|      10
---------------------------------------------------------------------------
 1488- 1506 (22.21/19.22)	PKSLQPAVLKnlknPPDAN
 1508- 1522 (29.59/15.16)	PYMKQDALFR....PPESN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.14|      22|      23|    1126|    1148|      11
---------------------------------------------------------------------------
 1126- 1148 (34.25/26.43)	LSCKDPFLkSKKKKYDTPVTSKF
 1150- 1171 (38.90/25.25)	IENEPPSM.SAELVYAPMVTRNF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31382 with Med13 domain of Kingdom Metazoa
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