<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31380

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFRIGGLHNVSWFQFLPSETELNPGFDRSSRAEQNEVATYLVLSSHLRLQKEGFLTTWTNSFVGPWDPSQGLYNPDEKIKLWLFLPGRHSSISDKAQAAVSKLRVVASGIWVAPGDSEEISVAFSQSLRNCIERALSGISYMRFGDVFSKFSPQSEEYLRRGQPTVEFIFAATEEAVFVHVIISAKNVRTLSSGDAERMLRSSLKNSSYRLPAFRKCLGLAKSEDNRLCYINTSHRPMLFPPVIVSPHGMRGSLTGFCPNDLVKQVYFSSGNLKTSTGYVGLPSHIGRGSRLINGNHCYVEVTLGCCQNRNDNTSQANSTFAVNLPHNQCPEPSVGSKDHRKGQSDLSSVCEKKFIYPAEAVLVPILQSAFAKFSLKRAGDFDCLGASENKSDGFYEKNGYNSSGSSRNSSISSTSSASSGSGWRMTSRTGDLDADADSLTCRQSGLTCNDDRLKMGSKRPRTGMAESFGQVGIENDQIGWDWDADDDDDDREVGMDIKALLSEFGDFGDFFENDALPFGEPPGTAESHVLVFPPDSADVGSSPVDMMDVSDQIVLPVGFSSFESFNPVPPIIDECLIKSQEVLHSSITSVPSNQMSISSTGEFDHLLKAEAMMTFAPEYGAVEAPMSEISSTFFKSPYLPKSHKVESSNSRTSNYVYGATPPTTDSDGAGDMILFGSKSCIGNNAGRTLYHSREHYTQVEGRKGRHDKLPTVISDNSSTKEGVSQSIHSKHSAANAVKVVQGKKTDGISAVVSTLLSSKTLLATDVGSVMFQAFMCRMRHIITSSKHSSPVSLTRLSGNFFLNQLSNEPSTLTDNISARNEIYKKDIPTRIAGDFDGGMLDSHMSAPVGVWRTVSVPKTAKPASSPNIEAGSSLPHSSFSEDSLLSYGQRQPLQDLLDGIALLVQQATSFVDLALDSDCGDGPYGWLALEELWRRELSCGPSAGHAGCGGTLASCHSLDIAGVKLVDPLSAEVFPSSVITLLQSDIKTALKSAFGQSDGPLSVTDWCKGRNQSGDGGSISEGFTAESALSEVNGVNISDDFIIDKYFGKQAVSNAIDGGKGDETAQSQDIYSSELLRPTLFVLPSPAILVGYQDDWLKISTNSLTHWEKAPFEPYALPKSINYAVVCPDIDPLTCAATDFFQQLGTGESTSLSFVKEVMLKHDRNWLGTHLPQSLGNQMEKDVGRLSSSGFVLLDCPQSMKIESNNTSLLGSLSDYFLSLSNGWNVNSYLKSLSKALKGLKLGSGLYTNQKEGSGSPCVVVYIVCPFPDPSAVLRTIVESSIALGSVIQSDRDRRSILNSQVARAFSSSTAVDEASISHIPVLSGFSVPKLVLQVVSVDSIFRITSPSFNELVILKDTAFSVYNKARRISRGMPNDAFFSSSLPSRSSSALTPMNSISGIWKDCGGSRMTGSTHPRDGEIDVSLRTSGWDTSTSWQIPRSGGLSCDPNRNGDFYLNDEIFYLFEPLFILSEPGSVERGVSPTFTSLGSESSKPIPEDGGRGSGPGMNSMEGITSGSSSQGDVSQLEGKAIPSLHCCYGWTEDWRWLVSIWTDARVLQQGCQILQACSSPDNGSFKPRDFVITRIGNFFELEYQEWQKAIYSAGGPEIKKWPIQLRRSAPSGIATNSNGSSLQQQDLSLIQERASSTSTLYSSHSKQSTFVKGSMGQSAGRKQIMGGQTISGTPRGLFQWVHSISFASISLDHSLHFVLPAELVSAGGGQSSTGMSSVNYIEGFTPVKSLGSTAFSYMMIPSPNMRFLHPSPLQLPTCLTAESPPLAHLLHSKGYAIPLSTGFVVSKAVPSMRKDSRINVKEEWPSVLSVSLIDYYGGYDNAHDKILQGIVKQGGGTKETRDFEVESHLILESIAAELHALSWMTVSPAYLDRRTALPFHCDMVLRLRRLLHFADKEVSRIPDKTGV
Length1921
PositionKinase
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.08
Grand average of hydropathy-0.253
Instability index49.37
Isoelectric point5.79
Molecular weight208459.70
Publications
PubMed=11130712
PubMed=27862469
PubMed=17272265
PubMed=20023166
PubMed=21257604
PubMed=22021418
PubMed=22247249

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts closely together with MAB12. Involved in the regulation of embryo patterning and cotyledon organogenesis. May act through transient repression of specific genes such as the ones responsive to auxin. 
ECO:0000269	PubMed:20023166
ECO:0000269	PubMed:21257604
ECO:0000269	PubMed:22247249
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
multicellular organism development	GO:0007275	IEA:UniProtKB-KW
regulation of development, heterochronic	GO:0040034	IMTAIR
regulation of growth	GO:0040008	IEA:UniProtKB-KW
regulation of radial pattern formation	GO:0090213	IMTAIR
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31380
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     194.85|      58|     159|    1190|    1250|       1
---------------------------------------------------------------------------
 1022- 1066 (24.89/ 7.80)	.............................G.SISEGFtaesaLSEVNGVNisddfiIDKYFgkQAVSNAIDG....GKG
 1193- 1250 (104.69/64.92)	SSGFVLLDCPQSMKIESN.NT.....SLLG.SLSDYF.....LSLSNGWN......VNSYL..KSLSKALKGL.KLGSG
 1794- 1850 (65.27/31.96)	STGFVVSKAVPSMRKDSRiNVkeewpSVLSvSLIDYY.........GGYD.......NAH......DKILQGIvKQGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     670.22|     173|     610|     833|    1021|       2
---------------------------------------------------------------------------
  383-  538 (193.88/96.41)	AGDFDclGasenksdGFYEKNGYNSSGSSRNSSISSTSSASSG.....SGWRMTSRTGDLDADADSLTCRQSGLTCND..DRLKMGSKRprtgmAESFGQVGIEND..QIGWDWDADDDDDDREVGMDIKAllS..EFGDFGDFFENDALPFG....EPPGTAEshvlVFP...................................
  837- 1011 (293.14/179.21)	AGDFD..G.......GMLDSHMSAPVGVWRTVSVPKTAKPASS.....PNIEAGSSLPHSSFSEDSLLSYGQRQPLQDllDGIALLVQQ.....ATSFVDLALDSDCGDGPYGWLALEELWRRELSCGPSA..G..HAGCGGTLASCHSLDIAGVKLVDPLSAE....VFPSSVI....TLLQSDIKTALKSAFGQSDGPLSVTDW
 1377- 1449 (98.29/44.14)	...............GMPNDAFFSSSLPSRSSSALTPMNSISGiwkdcGGSRMTGSTHPRDGEID.............................................................................................................V....SLRTSGWDTSTSWQIPRSGG.LS....
 1540- 1615 (84.91/33.77)	..........................................................................................................CC...YGW...TEDWRWLVSIWTDA..RvlQQGC.QILQACSSPDNGSFKPRD..........FVITRIgnffELEYQEWQKAIYSA....GGP.EIKKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.76|      32|     258|    1490|    1536|       4
---------------------------------------------------------------------------
 1498- 1534 (53.12/45.67)	PIPEDGGRGSGPGMNSmegitSGSS.SQGDVSQLEGKA
 1616- 1648 (51.64/16.82)	PIQLRRSAPSGIATNS.....NGSSlQQQDLSLIQERA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.75|      63|    1092|     199|     276|       9
---------------------------------------------------------------------------
  199-  267 (96.46/71.75)	DAERmlRSSLKNSSYRlpAFRKCLGLAKSEDNRLCYINTSHRPMLFPPVIVSPHGMRGSLTGFcpNDLV
 1296- 1358 (98.29/53.73)	DRDR..RSILNSQVAR..AFSSSTAVDEASISHIPVLSGFSVPKLVLQVVSVDSIFRITSPSF..NELV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.60|      15|     255|     330|     344|      11
---------------------------------------------------------------------------
  330-  344 (31.69/22.78)	PHNQCPEPSVGSKDH
  596-  610 (28.91/19.93)	PSNQMSISSTGEFDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.17|      24|     184|     164|     189|      12
---------------------------------------------------------------------------
  164-  189 (38.46/34.07)	RRGQPTV......EFIFAAteEAVFVHVIISA
  345-  374 (36.70/25.15)	RKGQSDLssvcekKFIYPA..EAVLVPILQSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.37|      41|     659|    1084|    1130|      14
---------------------------------------------------------------------------
 1084- 1130 (54.19/51.83)	TLF...VLPSPAILVGYQDDwLKISTnSLThwEKAPfePYA.LPKSINYAV
 1747- 1791 (68.18/38.18)	TAFsymMIPSPNMRFLHPSP.LQLPT.CLT..AESP..PLAhLLHSKGYAI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31380 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HSREHYTQVEGRKGRHDKLPTVISDNSSTKEGVSQSIH
2) VSPTFTSLGSESSKPIPEDGGRGSGPGMNSMEGITSGSSSQGD
696
1484
733
1526










Molecular Recognition Features






MoRF SequenceStartStop




1) VGMDIKALL
498
506