<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31379

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSENERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDAEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2027
PositionKinase
OrganismPan troglodytes (Chimpanzee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Pan.
Aromaticity0.06
Grand average of hydropathy-0.505
Instability index59.00
Isoelectric point6.35
Molecular weight226335.88
Publications
PubMed=12777533

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coactivator activity	GO:0003713	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31379
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     187.87|      15|      15|    1901|    1915|       1
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 1901- 1915 (36.22/13.14)	QQQQQQ....QQQ....QQQQQQ
 1918- 1936 (30.62/10.06)	QQQQQQ....QQQyhirQQQQQQ
 1938- 1952 (32.75/11.23)	LRQQQQ....QQQ....QQQQQQ
 1953- 1967 (35.56/12.78)	QQQQQQ....QQQ....QQQQHQ
 1968- 1982 (29.50/ 9.45)	QQQQQQ....AAP....PQPQPQ
 1983- 2001 (23.24/ 6.00)	SQPQFQrqglQQT....QQQQQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.14|      16|      17|    1639|    1654|       2
---------------------------------------------------------------------------
 1607- 1623 (21.55/ 8.16)	EKKAP.ePPKTDK..PGAAP
 1638- 1653 (29.77/14.50)	KRSQP..ATKTED..YGMGP
 1654- 1673 (18.82/ 6.06)	GRSGPygVTVPPDllHHPNP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.67|      13|      18|     196|     210|       3
---------------------------------------------------------------------------
  196-  210 (21.46/15.79)	LLMCPQhrPLVFGLS
  217-  229 (27.22/13.24)	LLCCPS..ALVWHYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     324.81|     116|     231|      63|     182|       4
---------------------------------------------------------------------------
   63-  133 (103.46/63.94)	...................................................................................................................................................................GSTIGPLPHDVE.V....AIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLL..RYSGE
  134-  182 (30.67/27.87)	FVQSAYLSRRLAYFCTRRLAlQLDGVSSHSShvISAQSTSTlPTTPAPQ................................................................................................................................................................................................
  297-  366 (75.10/43.70)	.................................................pptsstpstpfsdllmcpqhrplvfglscilqtillccpsalvwhysltdsriktgspldhlpiapsnlpmpegnsaftqqvraklreieqqikergqavevrwsfdkcqeataGFTIGRVLHTLE.VldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGR
  370-  452 (115.59/73.74)	MVVAKLLEKRQAEIEAERCG.ESEAADEKGS..IASGSLSA.PSAPIFQ..............................................................................................................................dV....LLQFLD..TQAPMLTDPRSENERVEFFNLVLLFCELIR......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     290.69|      96|     231|    1472|    1606|       5
---------------------------------------------------------------------------
 1472- 1600 (122.44/118.06)	.................GERQSDSLEKV.RQLLP.LPKQTRdvITCEPQGSlIDTKGnkIAGFDSIFK.....KEGLQvsTKQKISPWDLFEGLkpsaplswgwfgtvrvdrrvargeeQQrlllyHT..HLRPRPRAYYLEP..LPLPPEDEEPPA
 1719- 1830 (142.69/70.78)	PTY..PgvlpttmtgvmGLEPSSYKTSVyRQQQPaVPQGQR..LRQQLQAK.IQSQG..MLGQSSVHQmtpssSYGLQ..TSQGYTPYVSHVGL.........................QQ.....HT..G....PAGTMVPPsySSQPYQSTHPST
 1832- 1853 (25.55/10.55)	PTLvdP..........................................................................................................................trHLQQRPSGY.............VHQQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.56|      25|      26|    1007|    1031|       6
---------------------------------------------------------------------------
 1007- 1031 (44.13/26.67)	CSEQDSEPGARLTCRILLHLFKTPQ
 1035- 1059 (43.43/26.12)	CQSDGNKPTVGIRSSCDRHLLAASQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.61|      16|      17|     485|     501|       9
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  485-  501 (23.69/21.06)	DDPAdDAEHKEAEGSSS
  505-  520 (28.92/19.87)	EDPG.LSESMDIDPSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     700|     714|      10
---------------------------------------------------------------------------
  700-  714 (26.85/17.79)	LEQITSFALG.MSYHL
  716-  731 (23.14/14.25)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      23|    1408|    1421|      14
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 1408- 1421 (24.50/17.68)	LLEIIISGTV..DMQS
 1432- 1447 (20.20/13.14)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.96|      11|      21|     922|     932|      15
---------------------------------------------------------------------------
  922-  932 (21.19/13.19)	AILCAELTGYC
  945-  955 (22.77/14.81)	ALCCSSNNGTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     322.45|     104|     202|    1086|    1203|      17
---------------------------------------------------------------------------
 1086- 1203 (166.70/119.29)	GFTVTGGTEELpeEEGGG.GSGGRRQGGR..NISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDL.....QDPVLSSaqaqrlmqliCYPHRLLD.......NEDGenPQRQRIKRILQNLDQWTM
 1288- 1406 (155.75/86.66)	GHVLKAAGEEL..EKGQHlGSSSRKERDRqkQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIvnnwrDDQYLDD..........CKPKQLMHealklrlNLVG..GMFDTVQRSTQQTTEWAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.41|      26|     202|     759|     786|      18
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  759-  786 (39.83/36.80)	SDLVGSYTTSLClCIVAVLRHYHaCLIL
  788-  804 (21.66/10.25)	QDQMAQVFEGLC....GVVKH.......
  967-  990 (39.92/26.55)	SDL..SFHDSLA.TFVAILIARQ.CLLL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31379 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGI
2) GAPGPRPPSPFDDPADDAEHKEAEGSSSSKLEDPGLSESMDIDPSSSV
3) LEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQ
4) RAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVM
534
474
1735
1582
571
521
1910
1733










Molecular Recognition Features






MoRF SequenceStartStop




1) NIFGRY
2) QQYHIRQQQQQQILRQQQQ
2022
1925
2027
1943