<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31377

Description Isoform 3 of Mediator of RNA polymerase II transcription subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2176
PositionKinase
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.07
Grand average of hydropathy-0.514
Instability index57.72
Isoelectric point6.63
Molecular weight243078.71
Publications
PubMed=10198638
PubMed=15772651
PubMed=8724849
PubMed=9702738
PubMed=10480376
PubMed=10235266
PubMed=9225980
PubMed=10235267
PubMed=15175163
PubMed=15989967
PubMed=17081983
PubMed=16565090
PubMed=16595664
PubMed=17000779
PubMed=18691976
PubMed=18669648
PubMed=19369195
PubMed=19690332
PubMed=21269460
PubMed=23186163
PubMed=24275569
PubMed=24129315
PubMed=17369503
PubMed=17334363
PubMed=23395478
PubMed=26273451

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. 
GO - Cellular Component
mediator complex	GO:0016592	IDA:UniProtKB
membrane	GO:0016020	HDA:UniProtKB
nucleoplasm	GO:0005654	TAS:Reactome
nucleus	GO:0005634	IDA:UniProtKB
ubiquitin ligase complex	GO:0000151	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	NAS:UniProtKB
protein C-terminus binding	GO:0008022	IPI:UniProtKB
protein domain specific binding	GO:0019904	IPI:UniProtKB
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IDA:UniProtKB
transcription coactivator activity	GO:0003713	IDA:UniProtKB
transcription coregulator activity	GO:0003712	IDA:UniProtKB
ubiquitin protein ligase activity	GO:0061630	IEA:Ensembl
vitamin D receptor binding	GO:0042809	NAS:UniProtKB

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription by RNA polymerase II	GO:0045944	IDA:MGI
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IDA:UniProtKB
positive regulation of transcription, DNA-templated	GO:0045893	IDA:UniProtKB
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	TAS:Reactome
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31377
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     189.72|      15|      15|    2051|    2065|       1
---------------------------------------------------------------------------
 2051- 2065 (36.49/13.77)	QQQQQQ....QQQ....QQQQQQ
 2068- 2086 (30.89/10.56)	QQQQQQ....QQQyhirQQQQQQ
 2088- 2102 (33.19/11.87)	LRQQQQ....QQQ....QQQQQQ
 2103- 2117 (35.84/13.39)	QQQQQQ....QQQ....QQQQHQ
 2118- 2132 (30.08/10.09)	QQQQQQ....AAP....PQPQPQ
 2133- 2151 (23.22/ 6.16)	SQPQFQrqglQQT....QQQQQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     751.24|     216|     231|     349|     577|       2
---------------------------------------------------------------------------
  216-  440 (278.97/193.41)	.........GSTIGPLPHDVEV....AIRQWDYTEKLamfmfqDGMLDRHEF.LTWVLECFEkIRPGEDELLKLLLPLLL......RYSGE...FVQSAYLSRR.LAYFCTRRLAlQL..DGVSSHSShvISAQSTSTlPTTPAPQPPTSSTP...STPfsdLLMCPQ...HRPLVFGLscilqtILLCCPsaLVWH.......YSLT.DSR..IKTGSPldhLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWS
  441-  673 (334.93/211.23)	FDKCQEatAGFTIGRVLHTLEVLDSHSFERSDFSNSL......DSLCNRIFG.LGPSKDGHE.ISSDDDAVVSLLCEWAV....SCKRSGRHRAMVVAKLLEKR.QAEIEAERCG.ES..EAADEKGS..IASGSLSA.PSAPIFQDVLLQFL...DTQ.apMLTDPRsesERVEFFNL......VLLFCE..LIRHdvfshnmYTCTlISRgdLAFGAP...GPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSS
  676-  813 (137.34/76.17)	FEDMEK..PDFSLFSPTMPCEGKGSPSPEKPDVEKEV.....kPPPKEKIEGtLG........VLYDQPRHVQYATHFPIpqeeSCSHECNQRLVVLFGVGKQRdDARHAIKKIT.KDilKVLNRKGT..AETDQL.A.PIVPL.NPGDLTFLggeDGQ............................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     726.74|     194|     205|    1254|    1458|       3
---------------------------------------------------------------------------
 1064- 1222 (198.72/128.88)	..GH.HDPDRvnDIAILCAELTGYCKSL.....SAEWLG..VLKALCCSSNNgtcgFND.LLCNVDVSDLSfhdSLATFVAILI...............ARQCL.........................................LLEDLIRcAAIPSLLNAAcsEQDSEPGArlTCRILLHLFKT.PQLNPCQSDG.....NKPTVG.IRSSCDRHLLAASQNRIVDGAVFA
 1258- 1458 (310.84/235.06)	SGGR.RQGGR..NISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSND....LQDpVLSSAQAQRLM...QLICYPHRLLD.......NEDGenPQRQRIKRILQNLDQWTMrqssLELQLMIKQT....PNNEMNS....LLENIAK.ATIEVFQQSA..ETGSSSGS..TASNMPSSSKTKPVLSSLERSGVWL..VAPLIAKLPTSVQGHVLKAAGEELEKGQHLG
 1460- 1642 (217.18/139.04)	SSRKeRDRQK..QKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQ....I...VNNWRDDQYLD...D..CKPKQLMHealklrlNLVG..GMFDTVQRSTQQTTEWAM....LLLEIIISGTvdmqSNNELFTtvldMLSVLIN.GTLAADMSSI..SQGSMEEN..KRAYMNLAKKLQKELG..ERQSDSLekVRQLL.PLP......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      13|      17|     859|     875|       5
---------------------------------------------------------------------------
  863-  875 (24.86/20.04)	MSYHLPLVQHVQF
  880-  892 (22.52/ 6.89)	MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.58|      14|      17|    1664|    1680|       6
---------------------------------------------------------------------------
 1664- 1680 (16.87/22.02)	KIAGFDsIFkkEGLQVS
 1684- 1697 (28.71/19.86)	KISPWD.LF..EGLKPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     136.26|      25|      29|    1989|    2013|       7
---------------------------------------------------------------------------
 1913- 1941 (33.98/12.86)	Q..Q..LQQ...S..QGMlgqssVHQMTPSS.SYGLQTS
 1949- 1976 (27.91/ 9.19)	S..HvgLQQHtgP..AGT.....M..VPPSYsSQPYQST
 1989- 2013 (48.15/21.40)	R..H..LQQR..P..SGY.....VHQQAPTY.GHGLTST
 2015- 2045 (26.23/ 8.18)	RfsHqtLQQT..PmiSTM.....TPMSAQGV.QAGVRST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      17|    1027|    1039|       8
---------------------------------------------------------------------------
 1027- 1039 (25.11/16.53)	ENPAA.HTFTYTGL
 1045- 1058 (21.03/12.56)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.92|      20|      94|    1794|    1813|      10
---------------------------------------------------------------------------
 1768- 1797 (24.43/ 8.73)	KTDKPGAAPPsteerkkkstKGKKRS...........QPAT
 1798- 1828 (30.50/12.83)	KTEDYGMGPG..........RSGPYGvtvppdllhhpNPGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.75|      13|      53|    1842|    1854|      11
---------------------------------------------------------------------------
 1842- 1854 (27.07/15.50)	YTQNQPLPAGGPR
 1898- 1910 (24.68/13.26)	YRQQQPAVPQGQR
---------------------------------------------------------------------------











Associated diseases
Disease
breast cancer	PMID:29157917 PMID:30230586 PMID:27438523 PMID:26452386 PMID:26601288 PMID:22913342
prostate cancer	PMID:29157917 PMID:23836153 PMID:23661306 PMID:22610119 PMID:26924278 PMID:26383637
colon cancer	PMID:23178117 PMID:29507187
renal cell carcinoma	PMID:27050271
uterine tumors	PMID:31520353 PMID:26383637
Uterine leiomyoma (ULM)	PMID:33025089 PMID:23443020 PMID:30895261
endometrial polyps colorectal cancers	PMID:24980722
phyllodes tumors	PMID:25865354 PMID:30511242
extrauterine cancer	PMID:25595892
uterine smooth muscle tumors	PMID:28592321
colorectal cancers	PMID:23132392 PMID:28183795
castration-resistant prostate cancer	PMID:24938407
Breast fibroepithelial tumors	PMID:26437033
fibroadenomas	PMID:28513873
epithelial ovarian cancer	PMID:29735544
Thyroid Cancer	PMID:28634282
lung cancer	PMID:28055980
renal cancer	PMID:24504440 PMID:30895261
syndromic disorders Congenital heart disease	PMID:30905399
cardiovascular diseases	PMID:24751643
Alzheimer disease	PMID:21293490
Fragile X syndrome	PMID:31098807
uterine leiomyomas	PMID:25615570 PMID:32094355 PMID:25106763 PMID:30619444
Blepharophimosis	PMID:24715367
short humeri	PMID:24715367
hirschsprung disease	PMID:24715367
Goldberg-Shprintzen syndrome	PMID:24715367
Opitz-Kaveggia syndrome	PMID:24715367
breast fibroadenomas	PMID:25106763
pelvic inflammatory disease	PMID:28432313



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31377 with Med12 domain of Kingdom Metazoa
Unable to open file!