<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31374

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMLRKTNLRMGTADVYKQNKNQEEDMLTTERLKKGYQMPLTQYELQSLVFNASENKLIRLEKAQKRSQSMIASVIHKKGEFHMNYDRERKIPKEQLPCFAPHNWKRILSDRVKFFSALARGTPLQQLSQRIPGFRRKELLFLEFSDYNISYDRAIWCVKLLCILGFNSSSKTQKKTLLDVATLELSQACNKTTIWLVTQLYKSFRNPIKRREATKTWNYLTGFMKYMFDDGVLDKQEFLNDLTEVFNQLFLQKNFKNPSVLSTFMKYYVYFVEDLSSSLVLARRSSTLLCQALGFLFEMAQDKRKIDAYYDSANKTFIKKEFENEDGEIYEFEDYDDFIDMLDEIPDVPYFDETDKTPEAQAEELIKQHEKRKAGSLKKSERRRRRGLSKNRPKKMPQNPSNEASLDHDKVQIKQEPMDYDEYGGQQSDNSMDYDSFSHQYDPSYEPLPFKPLHTDIPKKLTDDEEFKYMKIGKRSVTPERISGRYGSMTYPFWIQQGGVGIDPPKDEVLDFSNPTPTETVNTQPQIDFESSPSASPALSVDKENECEKKEDESKTKEKNKDKEKDKEKEKSVDEHTNDLDVPINPDDAEMADANDKTDASEKQKLVEEEPTGKENEDDTSSKTAKTSTSAEKSEAPSIVDSNDKIDKEPNASSTSNDETSKDDTVPMESDPPAATEKPKESTEITTEEPLEVDKAPEVDKSEKEHEDDIMIIESNKKADEDDCVVIAVVDPDQEQTPESEKKKDGEEERDKNKDTDVADNEPEKIYTDEELAEIKIRKEKEMKIATLASHIKEKMVSDKKWKEKTSHAGWRTLDQCSQFSEALHLLSSMVQYMACVTPESFVWNDLSVQQEERRHRILPQLCGSPLDYLPCELHKLPVMEGVEEVVDCLRLRHCEIVRRSQAAEDRWLPNAAFLQSFGRIIDTCVDVIGIMDNIDVEKPNAITNAGLRLFAFREKFEKQEALLKTMLMFKWCITEEREGSFRATYIAKLLRFGMDQNPENTIGGWQVMDLFFKFMSTEGPKHGSKMYQAHFDSTVAIMIEMMREKIFSITDILRELEKDSDLDYNAPLMERQRKQKIPKISKRHRKPETPDDTKLVHFTTEYTPKRLFMGKKMDLLERMIIILPQLDVDEDTDEYRLRRLLLFGLKPAANVYFRRARAIYKSITKEFTTRLYIEFDRSSKVTTAHKKINQNRLDDLLRQFRAQTYHDQHLILERIVYNFIDGIGGFLKKNCDDVPAPEVANIICEMYEFSMDITSIFDFFEMVNPYLKAVDDKIAHFRMDVLPDMYYTETAFIFVSFFMKHWQRFLLHPRACAIVNQCFVLIQDMIRADDHMITCWGRTVAIFVFHARKAIANAGLQNEEFLAEDSHFWRVFPNAQHVDLDVGYFNEDFAGVKLQLRGGTLRYDSYNDFKWLVSNMKPNLKKKPHLKRPNTRYSFVVRAFMEARQHGRNFDRINELANYCANITANDPPLSEYWIGAIKGLCFLSLDAPYPFKEMSQQIDISDCSTHYSLTTFITCLAGKSAFYIPRLLAELTKHVFPLMLRHDGRLTSQKTHDVKRKVASKTTESRTLSEAEPGVCLCLLIICGLCCVGDEPFGLSVHYRGIEKKKKRFNNTADERIMHLFHWFEMDHAMFRTLGHISQLLEALQSRCRDANLVLPKNFPIKNPPKHQQELHREKAPYRPQYLFNIAKTVQFVICEQDWVTLRMFRFFQTRKMEAFNQDKLKQNCLGQQILRMALRRRTERENVHKLFEAHKISKKATVDKVLSFMNLWNFRATLFDLMLMIKEISPDGNSRHAQQGAIAADALMSEIGKCCRDMFLSAYKTKIKMPIAKTLTDFRLSDINKFWLIAPLVRMCPKPINIPPQYANTTVGTVAAKFLREAALLMDTPPTTPKERLLQCSWAMSKVPFINMILTCLQCEKMQQSKDVFLQSLYTQLQRETLRDHHRRSNWTNRREHRDCTIFRITLIGYIYKEILKATHVETWGLLIFQLMFHGIINPVREKLIYETCFDMLHHMVLWTLVDGDSMNQHDRYGSIRVRWPQYAGLMKKIRKEMQERFTDQTRNSLHRFLPIGKMQMSTISYKKYQKRPKVNQKMSKKFLAGEGLKNGKYSFLPEEKAKTNAFEHTDHLGDLIVKGGWKFRMFQTTRLDKVAKNVQNVLRSNMHHTHVLEFNRPQLLMSDNMFDDIFLAPPDIEITKIIEQPVPVIDEEEAKKRAEEEKEAAEKKEESKNAEDEKNKNNAENKKDTKEGEKGKSKDKEKDGEKEKCKDASKKDDVTSEKNELEKRASDAAAATNAPETNKDMDTSTPKPAPVTRSPATRGRGGGRKRNSGARGGGPRAKRANSRADTAQAAAATTQWNAPIANTSNPAAGGNFHAAMRGNQPPMSNGSSDETKVHIRNLLNRKKEEKRNSLADASAAAAAANSNAMGNTSSMPPSGPPMPMGSSMQSAGATQQLQGMQKHQMGGSMSGMNQNMGGMNQSMSHQAPPPYSSTNEMNRPLMNQYGGPHFAAPNPGPLNRSSGPVSSETRQQIMEQQMREKLAAHHQLVEQQKQRDAREREAREREAREHQERMQREAYMKEQQLLERKRAIEENNRIMEEQQREREMEAARKEAARRAAEEAYAAEQQRLELLRRQEEERLRKEAEERMRIQRENEERVRQEQMRLEAEERERIRRAEEERIQKELEDKVRREKEEAARQEKERQEQEARMREAREAELSRQRMEQQRRSQQNPYMNQQGQYSQQPPPSYQQSSYPNNYQPGQQGNQPPNYQQPSHQSMQQGHQAGYQQTSNQMQMNMQQQQNRQQGGPQQSFSGPGGINQPSQPGYSGYNQQGGQGQQGQMQQQRNPFGNQQDMQQPGAAKLMHAKPNEAHAQQYQHTQNQLSLAQKEKEKQYFQAKNLQASQANAQQQQQRFGDVVAGNVAGYGRPYGQQQLGASDQMGTSQLPGASTSRMNQGSSNPQGGMQSYQQQQPVLGQPGPIQTGQSTQQQIPAQSQQQYNSGRPQMHTTPTKNDMSARAPSGAMGQIANRMGHGTNPQGYGSTGQNVPGGYQQGQQQSGQGSYPQAQQQQPNQYSGSNQQVGQQAQQQQQQPLNQNVSQSQSAAQFGRPSQDSAYQQSGYNQTGNQSYQRPDQQQQGAQQNQWSGSNQAQNQLRSQQQAQQPLQQPQQSQQFQQPAQQAKNPMAQSAQYGGFGGQQQGYDQQQQGQIAPQQAQNPQASQSYGQQQTQQNRYGMGSSGYTANSGGSSNILNQSMEESGLNQGFSGASSNASSQQGGSSQMQQSGYGMPGNQMQMQQNQKQQVQRGMPTGMGQTNMGQSGMGQSGMGQTGMSRSGLGGGIGQQGQQSQQPQQPQVSQQQNQRGMNPGAQLPPYSTGQQQHQPQQSQISQQQQQQDQYRRMQAAQMQQQPTAQGQQNRMGMPSQQQSGAAYSNQMQFQGVRQGQQGMGGMGGSGQQQPQTQPHGSNQYYQQQQDQRMQQQPQQPGQQQQHGYGMGQYPNQQPPNQY
Length3498
PositionKinase
OrganismCaenorhabditis elegans
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.07
Grand average of hydropathy-0.966
Instability index54.02
Isoelectric point8.54
Molecular weight400774.81
Publications
PubMed=9851916
PubMed=10970880
PubMed=12441291
PubMed=15073178
PubMed=15790964

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functions downstream of let-60 during vulval induction. Required for asymmetric division of T-cells and for hypodermal development. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IDA:WormBase

GO - Biological Function
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
multicellular organism development	GO:0007275	IEA:UniProtKB-KW
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	IGI:WormBase
negative regulation of vulval development	GO:0040027	IGI:WormBase
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31374
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     281.63|      30|      30|    3326|    3355|       1
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 2725- 2748 (39.65/ 9.40)	RSQQNP...YMN..QQG.Q.YS.QQP..PP.S....YQQ....
 2825- 2853 (46.79/12.29)	GYNQQG...GQG..QQG.Q.MQ.QQ.RNPFGN....QQDMQ.Q
 3043- 3068 (34.57/ 7.35)	....PG...GY...QQGqQ.QS.GQGSYPQAQ....QQQPN.Q
 3069- 3099 (33.26/ 6.82)	YSGSNQ...QVG..QQAqQ.QQ.QQPLNQNVS....QSQSA.A
 3108- 3139 (35.97/ 7.92)	SAYQQS...GYN..QTG.N.QSyQRPDQQQQG....AQQNQwS
 3184- 3223 (31.72/ 6.20)	YGGFGGqqqGYDqqQQG.QiAP.QQAQNPQASqsygQQQTQ.Q
 3326- 3355 (59.67/17.49)	RSGLGG...GIG..QQG.Q.QS.QQPQQPQVS....QQQNQ.R
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.37|      18|      18|    2213|    2230|       3
---------------------------------------------------------------------------
  539-  558 (18.68/ 8.94)	SVDKE.nECEKK.EDESkTKEK
 2252- 2272 (19.69/ 9.95)	SKDKEkdGEKEKcKDAS.KKDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      94.26|      18|      18|    2670|    2687|       4
---------------------------------------------------------------------------
 2635- 2652 (27.32/11.88)	ERLRK.....EAEERMR.....IQRENE
 2653- 2675 (24.20/ 9.61)	ERVRQeqmrlEAEERER.....IRRAEE
 2676- 2698 (20.60/ 6.97)	ERIQK.....ELEDKVRrekeeAARQEK
 2699- 2715 (22.14/ 8.09)	ER..Q.....EQEARMR....eAREAEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.42|      18|      18|    3376|    3393|       5
---------------------------------------------------------------------------
 2790- 2806 (29.14/ 7.53)	MQMN.MQQQQNRQQGGPQ
 3371- 3387 (28.03/ 6.95)	QQ.HQPQQSQISQQQQQQ
 3388- 3405 (27.24/ 6.54)	DQYRRMQAAQMQQQPTAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     143.90|      18|      18|    3287|    3304|       6
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 2758- 2775 (25.43/ 7.94)	GQQGNQPPNYQQPS.HQSM
 2989- 3005 (23.04/ 6.32)	QSQQQYNSGRPQ.M.HTTP
 3149- 3166 (23.25/ 6.46)	RSQQQAQQPLQQPQ.QSQQ
 3291- 3309 (23.44/ 6.59)	NQKQQVQRGMPTGMgQTNM
 3435- 3447 (24.00/ 6.97)	GQQGMG..GM..GG.S.GQ
 3483- 3495 (24.75/ 7.48)	G.YGMG.Q.YP..N.QQPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.43|      16|      18|    2439|    2456|       7
---------------------------------------------------------------------------
 2454- 2472 (25.19/10.42)	GMQkhqMGGSM..SGMNQNMG
 2473- 2490 (22.24/14.45)	GMN...QSMSHqaPPPYSSTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     132.50|      18|      18|    2951|    2968|       8
---------------------------------------------------------------------------
 2807- 2821 (24.14/ 7.62)	QSFSGP..GGIN..QPSQP
 2861- 2877 (25.31/ 8.43)	HAKPN..EAHAQQYQHTQN
 2891- 2908 (22.43/ 6.43)	FQAKNL.QASQANAQQQQQ
 2951- 2968 (37.10/16.62)	QGSSNP.QGGMQSYQQQQP
 2970- 2987 (23.50/ 7.17)	LGQPGPiQTG.QSTQQQIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.66|      17|      18|    2213|    2230|       9
---------------------------------------------------------------------------
 2550- 2566 (23.93/11.58)	RDARERE..........AREREAREHQ
 2598- 2624 (19.72/ 9.66)	QREREMEaarkeaarraAEEAYAAEQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.26|      16|      18|    2213|    2230|      10
---------------------------------------------------------------------------
 2215- 2230 (25.34/19.64)	E.EKEAAEKKEESKNAE
 2232- 2248 (22.92/ 9.06)	EkNKNNAENKKDTKEGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.29|      14|      18|    3228|    3242|      11
---------------------------------------------------------------------------
 3228- 3242 (20.26/ 9.97)	MGSSGyTANSGG..SSN
 3411- 3426 (22.04/ 6.80)	MGMPS.QQQSGAaySNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     232.21|      78|     193|    1488|    1570|      12
---------------------------------------------------------------------------
 1488- 1570 (124.40/107.87)	APYP...FKEMSQQIDISDCSTHY.SLTTFITCLAGK.SAFYIPRL.laeLTKHVFPLMLRHdgRLTSQKTHDV..KRKVASKTTESRTLS
 1677- 1765 (107.81/78.88)	APYRpqyLFNIAKTVQFVICEQDWvTLRMFRFFQTRKmEAFNQDKLkqncLGQQILRMALRR..RTERENVHKLfeAHKISKKATVDKVLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.14|      18|      18|    2279|    2296|      13
---------------------------------------------------------------------------
 2293- 2312 (21.13/11.82)	APETnkDMDTSTPKPAPVTR
 2352- 2370 (23.01/13.81)	TTQW.nAPIANTSNPAAGGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.05|      18|      18|    1896|    1913|      14
---------------------------------------------------------------------------
 1896- 1913 (34.42/19.72)	LQCSW.AMSKVPFINMILT
 1915- 1933 (27.63/14.33)	LQCEKmQQSKDVFLQSLYT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.32|      12|      39|    3270|    3283|      17
---------------------------------------------------------------------------
 2933- 2944 (21.54/ 7.70)	SDQMGTSQL..PGA
 3311- 3324 (18.78/12.36)	QSGMGQSGMgqTGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.12|      14|      18|    3008|    3021|      24
---------------------------------------------------------------------------
 3008- 3021 (26.55/15.93)	NDMS.ARAPS..GAMGQ
 3024- 3040 (18.56/ 8.24)	NRMGhGTNPQgyGSTGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.19|      11|      18|    1809|    1819|      25
---------------------------------------------------------------------------
 1809- 1819 (22.62/13.48)	IGKCCRDMFLS
 1829- 1839 (18.57/ 9.75)	IAKTLTDFRLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.64|      17|      19|    3251|    3268|      26
---------------------------------------------------------------------------
 3251- 3268 (25.73/15.14)	SGLNQ.GFsGASSNASS.QQ
 3272- 3290 (25.91/10.80)	SQMQQsGY.GMPGNQMQmQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.96|      35|     143|     567|     601|      30
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  567-  601 (57.97/37.81)	EKEKSVDEHTNDLDVPINPDDAEMADANDKTDASE
  713-  747 (57.99/37.83)	ESNKKADEDDCVVIAVVDPDQEQTPESEKKKDGEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.02|      36|     141|    1283|    1318|      34
---------------------------------------------------------------------------
 1283- 1318 (69.68/41.81)	PDMYYTETAFIF.VSFFMKHWQRFLLHPRACAIVNQC
 1424- 1460 (62.35/36.60)	PHLKRPNTRYSFvVRAFMEARQHGRNFDRINELANYC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.44|      13|      19|     640|     652|      35
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  640-  652 (22.59/13.13)	DSNDKIDKEPNAS
  657-  669 (22.85/13.37)	DETSKDDTVPMES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.25|      17|      19|    2143|    2161|      36
---------------------------------------------------------------------------
 2143- 2161 (22.95/18.48)	TTRLDkvAKNVQNVLRSNM
 2164- 2180 (30.29/18.01)	THVLE..FNRPQLLMSDNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.34|      21|     141|    2371|    2391|      37
---------------------------------------------------------------------------
 2325- 2347 (26.78/13.58)	RNSGARGGGPRAkrANSRADTAQ
 2371- 2391 (39.19/24.44)	FHAAMRGNQPPM..SNGSSDETK
 2413- 2429 (18.37/ 6.22)	SAAAAAANSNAM..GNTSS....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31374 with Med12 domain of Kingdom Metazoa
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