<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31373

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMGTADVYEQHKNQEEDMLTTERLKKGYQVPVTHYELQSLIFNASENKLLRLDRAPRRTYCMISSIVHRRGEYHMNFDSNRKVAKGEMPRFAKIRFKRILEDRVKFFSALFRGTPLQYLQKKVPYYRRKELLLLEFYDYQIRYDRAIWCVKLVSILGFNCSAKAQKKALLDLATLEWSQACGKVTYYLLLALRKTYKKSRAAFRESVKMWYYMTRFMMYMFQDGVVDKHEFLNDLTEMFNVFFIRGSLANAKILELFMEYYIFFLDDLSSSLILARRASSLLCKALGLLSEINEAYTKTQVYKNENKHEFMGHQDVWTIDAQPKFDFEDYNRDHKEFIDPDDFFRFVDELPDAAYFEDYEDKTAEQVAEEELQTMEAPRRARNYIYSALKSVKTPVNDQIPVDLGDELYIPSDVESLTSPEPEEDPEEGPEEDPRSQSVPSPTFPAGPVSMEEAIPAYWRARGPVLQTVPQPAPQPVPKPVQQTVPKPVPRPPPRNLNIKSEQVDPEYEKNFGNPVKSKNFNINIKAEPMDYDEYSTEPPQPLQPPQTFQQRPKSPEKEKAPEPAAEPPRWTLEELPKNFLSKNLEVPAPWTRPRENPIERKRAYNLLCAKRFPVKEDVFEPFKDPDSPDGSRPASPIEPIPVKKLHKTPPKKVMTDDDEFGHIPAQKRKINPKLANGKYSETLFVYYLINGGVAFDPKHDGDEMDFSNPTPPEAPPPPPPVEFETSPSASPAPDTDKEDEDGKSKEGGDKAAEKSTDKPAEEKEASEKEKTGEKKDGDKPTEEKSKKGEKADGKKAVDEHLNDLIIPMDVEAEAATKRNSATNSKDDEAEDANKVAGDAPVVEATHAAGTSEKKPEAEVTPIETNDVEMESVDPATNKESTSDSTAEKSSDSQEPMEVDDPQKKLPSPAADKAGDDASKKTKEGKKPDTPAIELVDLEALDDIPLPTDDLMLPEEDEIQVIEKPKHPDADFCEVVEVVEKDKDKTPEKATEGEKEAEKDAEKLPEPAPVVESVPEPVKTPEKPKTPEPPRLYTAEEIEQLKKDKRRQRMLDRLTDAFKIQMESDKKYEENNIHPSFKVYDQSRSFRRPLHLLSSMVQYLAFRTPESFVWNNLEVPRPDKCHKILPQLCGSPLDHLPCELHELPVMEGNDGHVEHLRLRHHEIVRRSQAADENWLPGGADVLQYGRIIDACVDVIGLMDCINVERPNSIFKVSERLFNFREKFAKEEALLRIKLMFKWCISEEREGSFRPVYCARMLEYGLNRSDDGLIGGWQIMDLFFNFMATEGPKPGMANYQAKFDACAGIMIEMIRHKLFTVADILRELEKDLDIDYTLPLMARQRKQKMPKISKKEKTPEEPDNTKLIHFTTEHTPKRLFMGRKMDLLERMIIMLPQFGNNKDSDEYKIRNQLLFGLRPSENIYFRRAKTICQGICKEFDSKSYIEFNDYVTAHKKLNQSRLDDILRQFRAQTYHDQHVILEKIVIHLTENIGSFLEKKNGHLPAPEVVNIICEMYEYSMDITSIFDFFEVLHPYLKAVDEKVASFEMDLVPDMYHTEIAYIFVSFFMKHYQRFLLHKRNNHIVNQLYYSVRKMMMDKTRFITCWGRVIAIFVNHIRPVLIDGCFRIIHIEGNEREFARAHPNKRPFNLECSYFNEEFAGSKLSLRGATMRYDSFADMKWIVDNLKVTVKRKNSKPRTPNRYSFVIRAFMEARKHGQNFDRINELANYCANVTANDPPLSEYWIGAIKGLCCLCIDDSSQLFKEMAKKIDISDCSTHYSLSTFITCLAGKAAFYIPRLLHKLTEEVFSQMLHNDGRLTSHKTKDVKRKSANKTTETRTLSEAEPGVCLSLLIIAGLCCPGDEPFGLSVHYRGIEKKKKRFRQTADERIMHMFHWLEMDKSMFRTLASISKLLEALQSRCRDANLVLPQSFQLKHPIVDPNHPPPHEKAPYRPQFLFNIAKAVFFTICEQDWVTIRMYQFVRINKMEPFNQEKLKTNCLGQQLLRISLRRKTERSNVHSLFEAHKISKKATVDKVLSFMNLWNFRATLFDLMLMIKEISPDGNTRHAQQGAIAADALMSEIGKCCRDMFLAAYKADAKMPNVKKLMDFRFGDISKYWLLAPLVRMCPKPINIPPQYANTQVQTVAAKFLREASALMDTPPTTTPKERLLQCSWAMSKLPFINMILTCLACEKTQSGKDTFLNSVYQQLQREVFRDHNKRSNWTNRPEHRDCTVLRVNLIAYMYKEILKPTHVEVWGLLLYQLMFHGIINPSRERYVFENCYDMLQHMVLWTLVNGDNMNSHDRYGSIRVRWPNYAGLMKKIRKEIQDRHVHPSRTCLLRFLPIGKLQTSTISYKKYHKRTIRPSATKSKKFMSNEGIRSGKYVYLPEEKVKTNAYDHMKNIPDGIQKGGWKFRMFQTTRLDKVAKSALHQLRAKIPHTHIGEFKRPCNIMLDNMSEDFYLRPPEVEITKTVEPVADDEETAAVKKPEEETAEKKKDEAKKADEKTTKADDEKKKDETADAKKDNEKQKEEKDKPEDSAKAKTDDVTAKDTEKDTAAPTDAAKAAAAPVAAAPDANKEMDTSTPKPAPVTRETSTTRGRGGGRKRNSGGRAAGGSRAKRTNSRANANAETAAAAETSSTTKAGPSGGGSSNYHAAMRANQPPMSNGSSDETKANIRNLLNRKQEKRNSLADANAAAAVAAAAAAAAAAAGNIAPALAPIVQPGIPSAGASSTMPGVPPQQQPHPGMQHQSGMQHQGMGAGMGGMNPTMHAPPPYSSSSMNPFANQPHFAAPNQVPITNMAHRSTAAVTPEERKRIMEEQMHQKLAQQQLLIENQNRQREAREREAREHQERLHKIREEQMQKEAKIREEQMQLERQRAIEENNRIMEEQRILREKEEARRRMEEEQRRREEEARLAYHVEQERIRKEQERQAILEAERLKREEERERERQRLEQERLQREMEEKARREKEEQARIERERLERERVAREALAAQQAQQAQQAQQAQQAQQQRHRAMLEQQQRQQMINQQQQQQAPYGQQPPQGQPPSYQQSSYQNPSGYQQGQQSGQNQPPNYQQTSHTNPAIQQTQQPPAYQQDNAQMHMQNRQQQPGQQYGNQPQQQQSQQAQQGQYPQQYPQQLSQNQQMNQQNQQRNPFGAQPEMQIGGPKVLMQAKPDEAHAQQYQHTQAQLALSQMEKEKQYLKAKNLQAGQAAGQQQPRFGENPQQNAPGFNGNLPYPQQQQQQPQQPGTSQIPNTTPTRPANPMQGQQQQAGMQNYQNQPVLGQPGPMQPGGQAGQQQQNQFQRQGMHTTPTKNDMAMRQGQMGGQMGQQQGQMGQQMQNRPAQGLNQQSQGFQQQGGQQSAQASFNQPQNQFSGGQQQQQMGQNQGQNLQQGQNQFGRQAAPNQENFQQQPGFNQNAAGQNYQRPEQQQQSQNQWNQLNQQMRPQQPQQPSQQQQNLPFGRTEQSQQFQQQQQQPQHQQQNKPAMGQQGFNYQGQQQGQGFDQSSQQTQQHPNPHQQQGHMQQTHQQNASQQQQQYNQAQQQSQQQGNQFPGFSGSSNQARASNILNQSMEDAGLNQGFSSGNTSNQQASSTNQQGNYGMQQGQQNPMHGQMHHQQGQQNQNQQQRPGMGQQGMGQQGMGQQGGMGQSGRGQPGMGGQSAMGQHQHGMGRPTMGQPGMQQSGMQQQHGMQQQQPGAQQSGLQQAGMQQQHGGIGMGGMQQQGRNNYGSMGQQGQQSGQQQAQQHQQMSQQAQPRQMPGGGVQLPPYSMGQQQQTQQQQPNQQQMDHLRRQQQMQQMARQQAMQQQQQGGVQQGQPQMQGYGNQGQQQQQQFPQMQQHRGQGQQGHGMGGAGQQHQQVPQQQQNQYFQPQQQQDQRMQQQPGGQQQQQQGQSGQQQNNQHYNNMGQFPNQQQY
Length3902
PositionKinase
OrganismCaenorhabditis briggsae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.07
Grand average of hydropathy-0.998
Instability index58.49
Isoelectric point8.41
Molecular weight446125.63
Publications
PubMed=14624247

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31373
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|     406.24|      23|      23|    3623|    3645|       1
---------------------------------------------------------------------------
 2992- 3014 (30.86/ 6.53)	QAQQAQQAQQQRHR....AML.....EQ..QQRQ
 3114- 3136 (38.93/10.34)	QAQQGQYPQQYPQQ....LSQ.....NQ..QMNQ
 3320- 3344 (36.56/ 9.22)	QGQMGQQMQNRPAQ....GLN.....QQsqGFQQ
 3462- 3482 (32.27/ 7.20)	QQQPQHQQQNKPAM......G.....QQ..GFNY
 3518- 3540 (30.77/ 6.49)	NASQQQQQYNQAQQ....QSQ.....QQ..GNQF
 3606- 3631 (42.05/11.81)	QGQQNQNQQQRPGM.gqqGMG.....QQ..GMGQ
 3632- 3653 (30.37/ 6.30)	QGGMGQSGRGQPGMggqsA............MGQ
 3676- 3698 (37.14/ 9.49)	QHGMQQQQPGAQQS....GLQ.....QA..GMQQ
 3761- 3785 (32.24/ 7.18)	QQQTQQQQPNQQQM.......dhlrrQQ..QMQQ
 3797- 3817 (33.86/ 7.94)	QGGVQQ...GQPQM...qGYG.....NQ..GQQQ
 3837- 3854 (30.32/ 6.28)	MGGAGQQHQQVP..............QQ..QQNQ
 3875- 3895 (30.86/ 6.53)	QQQQGQSGQQQ..N....NQH.....YN..NMGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|     435.07|      27|      27|    3028|    3054|       2
---------------------------------------------------------------------------
 3028- 3051 (43.13/11.61)	GQQPPQGQPPSYQQSSYQNPSGY.Q...
 3053- 3076 (35.41/ 8.07)	GQQSGQNQPPNYQQTSHTNPA.I.QQ..
 3094- 3113 (35.90/ 8.30)	NRQQ...QPG..QQ..YGNQPQQ.QQSQ
 3235- 3259 (30.94/ 6.02)	..QPGTSQIPNTTPTRPANPMQG.QQQQ
 3261- 3285 (42.22/11.20)	GMQNYQNQPVLGQPGPMQ.PGG..QAGQ
 3292- 3318 (31.24/ 6.16)	QRQGMHTTPTKNDMAMRQGQMGG.QMGQ
 3347- 3369 (36.80/ 8.71)	GQQSAQA...SFNQPQNQ.FSGG.QQQQ
 3376- 3401 (34.09/ 7.47)	GQNLQQGQNQFGRQAA.PNQENF.QQQP
 3403- 3427 (32.12/ 6.56)	FNQNAAGQ..NYQRPEQQQQSQN.QWNQ
 3484- 3510 (40.21/10.27)	GQQQGQGFDQSSQQTQ.QHPNPHqQQGH
 3582- 3604 (39.12/ 9.77)	TNQ..QG.NYGMQQGQ.QNPMHG.QMHH
 3701- 3724 (33.89/ 7.38)	G...GIGMGGMQQQGRNNYGSMG.QQGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     189.75|      53|      75|    2841|    2913|       3
---------------------------------------------------------------------------
 2802- 2844 (36.98/ 8.52)	...........................EERKRIMEEqmhqklaqQQLLIENQN.RQREAREREA.......REHQERL.....
 2845- 2912 (81.50/55.96)	HkireeqmqkeakiREEQMQLERQRaiEENNRIMEE........QRILREKEEARRRMEEEQRR.......REEEARLAYHVE
 2932- 2985 (71.27/33.06)	K.............REEERERERQR........LEQ........ERLQREMEEKARREKEEQARiererleRERVAREALAAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.59|      24|      24|    2482|    2505|       4
---------------------------------------------------------------------------
 2482- 2505 (38.54/24.14)	ETAEKKKDEAKKADEKTTKADDEK
 2509- 2532 (35.04/21.11)	ETADAKKDNEKQKEEKDKPEDSAK
 2572- 2589 (18.02/ 6.35)	DTSTPKPAPVTR.ETSTTR.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     280.42|      67|      75|     567|     641|       5
---------------------------------------------------------------------------
  491-  555 (92.04/49.77)	PP.......PRNLNIKSEQVDPEYEKNFGNPV.KSKNFN.INIKAEPMDYDE.YsteppQPLQPPQTFQ.QRPKSP....
  567-  640 (114.42/78.91)	PPrwtleelPKNFLSKNLEVPAPWTRPRENPIERKRAYNLLCAKRFPVKEDV.F.....EPFKDPDSPDGSRPASPIEPI
  664-  716 (73.95/40.56)	......................PAQKRKINPKLANGKYSETLFVYYLINGGVaF.....DPKHDGDEMDFSNPTPPEAPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.48|      23|      31|     874|     901|       6
---------------------------------------------------------------------------
  874-  901 (30.16/28.26)	PATNKesTSDSTAEKSSDSQEPmevDDP
  908-  930 (39.32/21.31)	PAADK..AGDDASKKTKEGKKP...DTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.03|      25|      77|     376|     400|       8
---------------------------------------------------------------------------
  376-  400 (42.31/22.15)	APRRARNYIYSALKSVKTPVNDQIP
  401-  425 (39.44/20.07)	VDLGDELYIPSDVESLTSPEPEEDP
  456-  477 (40.28/20.68)	AYWRARGPV...LQTVPQPAPQPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.86|      28|      32|     738|     765|       9
---------------------------------------------------------------------------
  738-  758 (26.59/15.29)	............................EDEDGKSKEGGDKAAEK.STDK
  759-  787 (40.50/28.87)	PAEEKEA....................sEKEKTGEKKDGDKPTEE.KSKK
  790-  839 (24.77/13.52)	KADGKKAvdehlndliipmdveaeaatkRNSATNSKDDEAEDANKvAGDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.61|      17|      32|    2601|    2617|      10
---------------------------------------------------------------------------
 2601- 2617 (27.33/14.12)	GRAAGGSRAKRTNSRAN
 2635- 2651 (28.37/14.96)	GPSGGGSSNYHAAMRAN
 2667- 2683 (21.90/ 9.72)	IRNLLNRKQEKRNSLAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.36|      26|      26|     305|     330|      11
---------------------------------------------------------------------------
  305-  330 (51.53/34.25)	NKHEFMGHQDVWT.IDAQPKFD.FEDYN
  332-  359 (39.83/24.47)	DHKEFIDPDDFFRfVDELPDAAyFEDYE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     254.38|      74|      76|    2193|    2268|      12
---------------------------------------------------------------------------
 2193- 2268 (124.88/100.18)	FLNsVYQQLQREVFRDHNKRSNWTNRPEHRDCTVLRVN...LIAYMYKEIlKPTHVEVWGLLLYQLMFHGIINPSRERY
 2270- 2346 (129.50/94.31)	FEN.CYDMLQHMVLWTLVNGDNMNSHDRYGSIRVRWPNyagLMKKIRKEI.QDRHVHPSRTCLLRFLPIGKLQTSTISY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.26|      19|      25|     983|    1006|      13
---------------------------------------------------------------------------
  986- 1006 (29.48/25.38)	P..EKATEGEKEAEKdaEKLPEP
 1008- 1028 (32.79/12.97)	PvvESVPEPVKTPEK..PKTPEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     164.75|      44|      76|    2050|    2093|      15
---------------------------------------------------------------------------
 2050- 2093 (74.47/54.17)	EISPDGNTRHAQQGAI....AADALMS.EIGKCC.RDMFLAA.YKADAKMP
 2096- 2123 (25.39/11.89)	......................KKLMDfRFGDIS.KYWLLAPlVRMCPKPI
 2124- 2172 (64.89/45.91)	NIPPQYANTQVQTVAAkflrEASALMD.TPPTTTpKERLLQC.SWAMSKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.94|      24|      27|    2710|    2736|      16
---------------------------------------------------------------------------
 2713- 2736 (47.98/27.74)	QPGIPSAGASSTMPGV.PPQQQPHP
 2741- 2765 (41.95/16.22)	QSGMQHQGMGAGMGGMnPTMHAPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     234.15|      74|      77|    1422|    1497|      18
---------------------------------------------------------------------------
 1422- 1497 (121.16/106.40)	AKTICQGICKEFDSKSYIE..FNDYVTAHKKLNQsrLDDILRQFRAQTYHDQ.HVILEKIVI.HLTENIGSF.LEKKNGHL
 1499- 1577 (113.00/91.59)	APEVVNIICEMYEYSMDITsiFDFFEVLHPYLKA..VDEKVASFEMDLVPDMyHTEIAYIFVsFFMKHYQRFlLHKRNNHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     153.39|      21|      77|    3654|    3674|      20
---------------------------------------------------------------------------
 3138- 3162 (28.97/ 7.49)	NQQRNPFGAQP.EMQIGGpkvlMQAK
 3207- 3232 (28.25/ 7.08)	RFGENPQQNAP.GFQQ......QQQQ
 3429- 3445 (34.76/10.85)	NQQMRPQ..QP...QQPS....QQQQ
 3656- 3675 (33.34/10.02)	HGMGRPTMGQP.GMQQSG....MQQ.
 3734- 3754 (28.07/ 6.98)	HQQMSQQ.AQPrQMPGGG....VQLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.27|      12|      25|    3542|    3553|      21
---------------------------------------------------------------------------
 3542- 3553 (22.00/13.50)	GF.SGSSNQARAS
 3568- 3580 (18.27/ 9.59)	GFsSGNTSNQQAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.94|      22|      25|    1855|    1878|      22
---------------------------------------------------------------------------
 1855- 1878 (34.43/25.92)	DEPFGLSVHYrgIEKKKKRFRQTA
 1879- 1900 (42.51/25.28)	DERIMHMFHW..LEMDKSMFRTLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.99|      16|      27|    1204|    1219|      23
---------------------------------------------------------------------------
 1204- 1219 (30.03/25.49)	RPNSIFK..VS.ERLFNFR
 1230- 1248 (19.96/13.54)	RIKLMFKwcISeEREGSFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.86|      28|      31|    2368|    2395|      29
---------------------------------------------------------------------------
 2368- 2395 (50.42/32.08)	EGIRSG..KYVYLPE...EKVKTNAYDHMK.NIP
 2396- 2429 (34.44/19.29)	DGIQKGgwKFRMFQTtrlDKVAKSALHQLRaKIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.65|      19|      31|    1950|    1970|      30
---------------------------------------------------------------------------
 1950- 1970 (31.67/25.02)	FNIAKavFFTIC.EQDWVTIRM
 1982- 2001 (28.97/16.35)	FNQEK..LKTNClGQQLLRISL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.76|      16|      28|    1585|    1600|      31
---------------------------------------------------------------------------
 1585- 1600 (31.90/21.34)	VRKMMMDKT.RFITCWG
 1610- 1626 (24.85/14.90)	IRPVLIDGCfRIIHIEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.54|      10|      27|    3167|    3176|      32
---------------------------------------------------------------------------
 3167- 3176 (19.15/ 9.81)	HAQQYQHTQA
 3191- 3200 (16.40/ 7.10)	KAKNLQAGQA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31373 with Med12 domain of Kingdom Metazoa
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