Description | Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MAEKFDNLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFLVTGLQDIDKCRQQLHDITVPLEVFDYIDQGRNPQLYTKECLERALAKNEQVKGKIDTLKKFKSLLIQELSKVFPEDMAKYKAIRGEDHPPS |
Length | 135 |
Position | Middle |
Organism | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Silurana. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.569 |
Instability index | 37.85 |
Isoelectric point | 5.64 |
Molecular weight | 15588.67 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250 |
GO - Cellular Component | chromatin GO:0000785 IBA:GO_Central mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central |
GO - Biological Process | atrioventricular canal development GO:0036302 IEA:Ensembl cardiac jelly development GO:1905072 IEA:Ensembl positive regulation of transcription by RNA polymerase II GO:0045944 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP31350 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) AKYKAIRGE 2) QVKGKIDTL 3) YTKECLERALAKN | 122 94 80 | 130 102 92 |
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