<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31348

Description Mediator of RNA polymerase II transcription subunit 10
SequenceMLPQDDMTDEMKSLASRLEDTTQAFYDLALIVYNLEDTTPSDAIPESLDTLIRDLKSLPDISRKVNNLIPQDVLEYIEQGRNPDVYARQFSELVQKDNQYVNGKLYAIEGFQKAFAEEIKQAYPEVSSVVDKILNEGKVESTVS
Length144
PositionMiddle
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Schizosaccharomycetes> Schizosaccharomycetales> Schizosaccharomycetaceae> Schizosaccharomyces.
Aromaticity0.08
Grand average of hydropathy-0.465
Instability index40.57
Isoelectric point4.29
Molecular weight16338.09
Publications
PubMed=11859360
PubMed=21511999
PubMed=10625684
PubMed=11572939
PubMed=16823372

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
chromatin	GO:0000785	IBA:GO_Central
cytosol	GO:0005829	HDA:PomBase
mediator complex	GO:0016592	IDA:PomBase
nuclear envelope	GO:0005635	HDA:PomBase
nucleus	GO:0005634	HDA:PomBase
P:positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IPomBase

GO - Biological Function
transcription coactivator activity	GO:0003713	TAS:PomBase
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IC:PomBase









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31348
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.48|      21|      22|      59|      80|       1
---------------------------------------------------------------------------
   59-   80 (30.76/26.39)	PDI.SRKVNNLIPQDVLEYIEqG
   83-  103 (27.04/17.66)	PDVyARQFSELVQKDN.QYVN.G
  124-  140 (17.68/ 8.92)	PEV.SSVVDKILNEGKVE.....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31348 with Med10 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) AIPESLDTLIRDLK
2) FYDLALIVYNL
3) ISRKVNNLIPQDV
4) KSLASRL
43
25
61
12
56
35
73
18