Description | Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MTTSTIEQKDENEPLLATADQVSALIESFIELGVLVHDNQGTQQSHTALTHKTNQVISQLSGLTSSPFTHQFPIPVDVISYIEDGRNPDIYTREFIEVTAKSNARLKGKMKAFARLRDVLGEKLGNEFPRLVDSIDDIKKRTTPEE |
Length | 146 |
Position | Middle |
Organism | Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Scheffersomyces. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.472 |
Instability index | 43.84 |
Isoelectric point | 5.22 |
Molecular weight | 16324.15 |
Publications | PubMed=17334359 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP31346 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) FTHQFPIPVDVISYIE 2) PDIYTREFIEVTAK | 68 88 | 83 101 |
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