<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31340

Description Mediator of RNA polymerase II transcription subunit 10
SequenceMAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPPS
Length135
PositionMiddle
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.07
Grand average of hydropathy-0.599
Instability index38.94
Isoelectric point5.82
Molecular weight15687.78
Publications
PubMed=15334068
PubMed=15489334
PubMed=10024883
PubMed=10993082
PubMed=15175163
PubMed=15989967
PubMed=21269460

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
chromatin	GO:0000785	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
nucleoplasm	GO:0005654	IDA:HPA
ubiquitin ligase complex	GO:0000151	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
ubiquitin protein ligase activity	GO:0061630	IEA:Ensembl

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	TAS:Reactome









Interaction





Binary Interactions
[Q9BTT4<-->Q9NYB9-2: ABI2]	NbExp=3	EBI-394354,EBI-11096309
[Q9BTT4<-->Q99819: ARHGDIG]	NbExp=3	EBI-394354,EBI-10295284
[Q9BTT4<-->P04066: FUCA1]	NbExp=3	EBI-394354,EBI-2512153
[Q9BTT4<-->O43513: MED7]	NbExp=7	EBI-394354,EBI-394632
[Q9BTT4<-->Q9H8W5-2: TRIM45]	NbExp=3	EBI-394354,EBI-11993364












Repeat regions





Repeats

>MDP31340
No repeats found
No repeats found











Associated diseases
Disease
including cancers	PMID:27688401
colon and gastric cancers	PMID:28231524



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31340 with Med10 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) MAKYRSIRGE
121
130