<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31335
Description |
Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MAPINPDLQNVQDDIKNVIQDLFQVLVQVSNYDAAGRPTRDVLAQDIQTLDKTLHTLHTNAQHLPTPTADKPIPEPLIQYVENGRNPDIYTREFAELVRRMNQLARGKMHAFRDFRDVLAREMESALPELRADVQMVVGATGGRTVGGEGEGAGQGEGGEGRGEGGN |
Length | 167 |
Position | Middle |
Organism | Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.589 |
Instability index | 23.45 |
Isoelectric point | 4.95 |
Molecular weight | 18297.22 |
Publications | PubMed=25720678
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP31335
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 111.22| 34| 74| 37| 73| 2
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37- 73 (54.53/36.67) RPTRDVLAQDiqtLDKTLHTLHTNAQHLPTPTADKPI
113- 146 (56.68/31.34) RDFRDVLARE...MESALPELRADVQMVVGATGGRTV
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