Description | Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MVQQQQQSQQRMMELHERNDREKLARKTEKEREEERRKQEDDKILQLEKKLEEFQENARFIGDLASNFQTKYQDALNGRIYTLVRGLQDLDRMKGTFSDKKVPLDLLPYLDDGKNPCLYSKHCMEKTLEKNKAVNGKIEIYKKFRAHLMKEFSEEMPDLVMYYRSIREDLDLS |
Length | 173 |
Position | Middle |
Organism | Caenorhabditis elegans |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis. |
Aromaticity | 0.08 |
Grand average of hydropathy | -1.126 |
Instability index | 51.47 |
Isoelectric point | 6.86 |
Molecular weight | 20828.54 |
Publications | PubMed=9851916 PubMed=10611325 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity). Required for
germ cell development and for transcriptional activation of certain
stage-specific inducible promoters.
ECO:0000250 ECO:0000269 PubMed:10611325 |
GO - Cellular Component | chromatin GO:0000785 IBA:GO_Central mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central |
GO - Biological Process | positive regulation of transcription by RNA polymerase II GO:0045944 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP31332 No repeats found |
MoRF Sequence | Start | Stop |
1) RMMELHERN 2) VPLDLLPYLD 3) YYRSIR | 11 102 162 | 19 111 167 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab