<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31323

Description Mediator of RNA polymerase II transcription subunit 37f
SequenceMARSFGANSTVVLAIIFFGCLFAFSTAKEEATKLGSVIGIDLGTTYSCVGVYKNGHVEIIANDQGNRITPSWVGFTDSERLIGEAAKNQAAVNPERTVFDVKRLIGRKFEDKEVQKDRKLVPYQIVNKDGKPYIQVKIKDGETKVFSPEEISAMILTKMKETAEAYLGKKIKDAVVTVPAYFNDAQRQATKDAGVIAGLNVARIINEPTAAAIAYGLDKKGGEKNILVFDLGGGTFDVSVLTIDNGVFEVLSTNGDTHLGGEDFDHRIMEYFIKLIKKKHQKDISKDNKALGKLRRECERAKRALSSQHQVRVEIESLFDGVDLSEPLTRARFEELNNDLFRKTMGPVKKAMDDAGLQKSQIDEIVLVGGSTRIPKVQQLLKDFFEGKEPNKGVNPDEAVAYGAAVQGGILSGEGGDETKDILLLDVAPLTLGIETVGGVMTKLIPRNTVIPTKKSQVFTTYQDQQTTVSIQVFEGERSLTKDCRLLGKFDLTGVPPAPRGTPQIEVTFEVDANGILNVKAEDKASGKSEKITITNEKGRLSQEEIDRMVKEAEEFAEEDKKVKEKIDARNALETYVYNMKNQVSDKDKLADKLEGDEKEKIEAATKEALEWLDENQNSEKEEYDEKLKEVEAVCNPIITAVYQRSGGAPGAGGESSTEEEDESHDEL
Length668
PositionUnknown
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.06
Grand average of hydropathy-0.467
Instability index31.13
Isoelectric point5.11
Molecular weight73560.35
Publications
PubMed=8888624
PubMed=10470850
PubMed=27862469
PubMed=14593172
PubMed=11599561
PubMed=11402207
PubMed=16781668
PubMed=17560376
PubMed=17272265
PubMed=18494858
PubMed=20080634
PubMed=20231441
PubMed=22021418
PubMed=24486762
PubMed=26251880
PubMed=31410484

Function

Annotated function In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions (Probable). Involved in polar nuclei fusion during female gametophyte development and is essential for the regulation of endosperm nuclei proliferation (PubMed:20080634). Involved in sperm nuclear fusion with central cell polar nuclei at fertilization, which is critical for normal endosperm nuclear proliferation (PubMed:31410484). Required for pollen development and pollen tube growth (PubMed:24486762). 
ECO:0000269	PubMed:20080634
ECO:0000269	PubMed:24486762
ECO:0000269	PubMed:31410484
ECO:0000305	PubMed:11402207
GO - Cellular Component
cell wall	GO:0005618	IDA:TAIR
cytoplasm	GO:0005737	IBA:GO_Central
endoplasmic reticulum	GO:0005783	IDA:TAIR
endoplasmic reticulum chaperone complex	GO:0034663	IBA:GO_Central
endoplasmic reticulum lumen	GO:0005788	IBA:GO_Central
mediator complex	GO:0016592	IDA:UniProtKB
membrane	GO:0016020	IBA:GO_Central
nucleolus	GO:0005730	IDA:TAIR
nucleus	GO:0005634	IDA:TAIR
plasma membrane	GO:0005886	IDA:TAIR
plasmodesma	GO:0009506	IDA:TAIR
plastid	GO:0009536	HDA:TAIR
secretory vesicle	GO:0099503	HDA:TAIR
vacuolar membrane	GO:0005774	IDA:TAIR
vacuole	GO:0005773	IDA:TAIR
GO - Biological Function
ATP binding	GO:0005524	IBA:GO_Central
ATPase activity	GO:0016887	IBA:GO_Central
heat shock protein binding	GO:0031072	IBA:GO_Central
misfolded protein binding	GO:0051787	IBA:GO_Central
protein folding chaperone	GO:0044183	IBA:GO_Central
unfolded protein binding	GO:0051082	IBA:GO_Central
GO - Biological Process
cellular response to unfolded protein	GO:0034620	IBA:GO_Central
chaperone cofactor-dependent protein refolding	GO:0051085	IBA:GO_Central
endoplasmic reticulum unfolded protein response	GO:0030968	IBA:GO_Central
protein refolding	GO:0042026	IBA:GO_Central
response to cadmium ion	GO:0046686	IETAIR
response to endoplasmic reticulum stress	GO:0034976	IETAIR
ubiquitin-dependent ERAD pathway	GO:0030433	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31323
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.78|      25|      27|     579|     604|       1
---------------------------------------------------------------------------
  550-  569 (24.25/11.23)	.....VKEAEEFAEE.DKKVKEK.IDA
  579-  604 (38.16/26.37)	NMKNQVSDKDKLADKlEGDEKEK.IEA
  613-  633 (29.36/15.14)	LDENQNSEKE......EYDEKLKeVEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.93|      29|     244|     395|     423|       3
---------------------------------------------------------------------------
  395-  423 (50.89/29.98)	NPDEA.VAYGAAVQGGILSGEGGDETKDIL
  424-  445 (23.71/10.12)	LLDVApLTLGIETVGGVM.......TKLI.
  648-  668 (29.33/14.23)	.........GAPGAGGESSTEEEDESHDEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.72|      16|      16|     185|     200|       6
---------------------------------------------------------------------------
  185-  200 (27.29/17.89)	AQRQATKDAGVIA.GLN
  202-  218 (20.42/11.60)	ARIINEPTAAAIAyGLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.93|      30|     198|      36|      68|       7
---------------------------------------------------------------------------
   36-   68 (44.10/40.11)	SVIGIDLGtTYSCVGvyKNGHVEIIANDQGNRI
  239-  268 (52.83/35.10)	SVLTIDNG.VFEVLS..TNGDTHLGGEDFDHRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.57|      13|      27|     498|     510|       9
---------------------------------------------------------------------------
  498-  510 (23.01/12.74)	APRGTPQIEVTFE
  525-  537 (20.56/10.72)	ASGKSEKITITNE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31323 with Med37 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ITAVYQRSGGAPGAGGESSTEEEDESHDEL
2) KDKLADKLEGDEKEKIEAATKEALEWLDENQNSEKEEYDEKLKE
639
587
668
630










Molecular Recognition Features






MoRF SequenceStartStop




1) KEVEAVCNP
629
637