<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31322

Description Probable mediator of RNA polymerase II transcription subunit 37e
SequenceMSGKGEGPAIGIDLGTTYSCVGVWQHDRVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPVNTVFDAKRLIGRRFSDSSVQSDMKLWPFKIQAGPADKPMIYVEYKGEEKEFAAEEISSMVLIKMREIAEAYLGVTIKNAVVTVPAYFNDSQRQATKDAGVIAGLNVMRIINEPTAAAIAYGLDKKATSVGEKNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRMVNHFVQEFKRKSKKDITGNPRALRRLRTSCERAKRTLSSTAQTTIEIDSLYEGIDFYSTITRARFEELNMDLFRKCMEPVEKCLRDAKMDKSTVHDVVLVGGSTRIPKVQQLLQDFFNGKELCKSINPDEAVAYGAAVQGAILSGEGNEKVQDLLLLDVTPLSLGLETAGGVMTTLIPRNTTIPTKKEQVFSTYSDNQPGVLIQVYEGERARTKDNNLLGKFELSGIPPAPRGVPQITVCFDIDANGILNVSAEDKTTGQKNKITITNDKGRLSKDEIEKMVQEAEKYKSEDEEHKKKVEAKNALENYAYNMRNTIQDEKIGEKLPAADKKKIEDSIEQAIQWLEGNQLAEADEFEDKMKELESICNPIIAKMYQGAGGEAGGPGASGMDDDAPPASGGAGPKIEEVD
Length651
PositionUnknown
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.06
Grand average of hydropathy-0.436
Instability index35.37
Isoelectric point5.03
Molecular weight71356.92
Publications
PubMed=8049382
PubMed=11130714
PubMed=27862469
PubMed=14593172
PubMed=16666375
PubMed=8075396
PubMed=11599561
PubMed=11402207
PubMed=11807141
PubMed=12805626
PubMed=15805473
PubMed=16003391
PubMed=16636050
PubMed=17272265
PubMed=18065690
PubMed=19617588
PubMed=20543027
PubMed=21612577
PubMed=21418353
PubMed=21586649
PubMed=22021418
PubMed=22092075
PubMed=22223895
PubMed=26408532
PubMed=28004282

Function

Annotated function In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions (Probable). Probably involved in defense response. Chaperone involved in protein targeting to chloroplasts. May cooperate with SGT1 and HSP90 in R gene-mediated resistance towards the oomycete Hyaloperonospora parasitica (downy mildew). Plays a role with WPP-domain proteins in facilitating WIT1 nuclear envelope targeting (PubMed:12805626, PubMed:18065690, PubMed:19617588). Modulates stomatal aperture in response to various environmental conditions and physiological responses to the hormone abscisic acid (ABA) (PubMed:21586649). 
ECO:0000269	PubMed:12805626
ECO:0000269	PubMed:18065690
ECO:0000269	PubMed:19617588
ECO:0000269	PubMed:21586649
ECO:0000305	PubMed:11402207
GO - Cellular Component
apoplast	GO:0048046	IDA:TAIR
cell wall	GO:0005618	IDA:TAIR
chloroplast	GO:0009507	IDA:TAIR
cytoplasm	GO:0005737	IDA:UniProtKB
cytosol	GO:0005829	IDA:TAIR
cytosolic ribosome	GO:0022626	IDA:TAIR
Golgi apparatus	GO:0005794	IDA:TAIR
nucleolus	GO:0005730	IDA:TAIR
nucleus	GO:0005634	IDA:TAIR
plasma membrane	GO:0005886	IDA:TAIR
plasmodesma	GO:0009506	IDA:TAIR
vacuolar membrane	GO:0005774	IDA:TAIR
GO - Biological Function
ATP binding	GO:0005524	IBA:GO_Central
ATPase activity	GO:0016887	IBA:GO_Central
heat shock protein binding	GO:0031072	IBA:GO_Central
misfolded protein binding	GO:0051787	IBA:GO_Central
mRNA binding	GO:0003729	IDA:TAIR
protease binding	GO:0002020	IPI:UniProtKB
protein folding chaperone	GO:0044183	IBA:GO_Central
unfolded protein binding	GO:0051082	IBA:GO_Central
GO - Biological Process
cellular response to unfolded protein	GO:0034620	IBA:GO_Central
chaperone cofactor-dependent protein refolding	GO:0051085	IBA:GO_Central
defense response to bacterium	GO:0042742	IMUniProtKB
defense response to fungus	GO:0050832	IMUniProtKB
defense response to other organism	GO:0098542	IMTAIR
heat acclimation	GO:0010286	IMTAIR
negative regulation of seed germination	GO:0010187	IMTAIR
protein refolding	GO:0042026	IBA:GO_Central
response to cadmium ion	GO:0046686	IETAIR
response to cold	GO:0009409	IETAIR
response to heat	GO:0009408	IMUniProtKB
response to virus	GO:0009615	IETAIR
stomatal closure	GO:0090332	IMTAIR

Interaction

Binary Interactions
[P22953<-->Q9SUT5: SGT1B]	NbExp=3	EBI-1238845,EBI-1581364

Repeat regions

Repeats

>MDP31322
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.81|      18|      21|      38|      55|       1
---------------------------------------------------------------------------
   16-   33 (19.07/ 9.06)	....TTYSCVGVWQHDRveIIA
   38-   55 (32.55/19.78)	NR..TTPSYVAFTDSER..LIG
   60-   78 (24.19/13.13)	NQvaMNPVNTVF.DAKR..LIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.29|      23|      26|     535|     560|       2
---------------------------------------------------------------------------
  535-  560 (33.05/33.74)	DEEHKKKVEA..KNALENyayNMRNTIQ
  561-  585 (32.24/22.05)	DEKIGEKLPAadKKKIED...SIEQAIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.01|      23|      26|     458|     482|       4
---------------------------------------------------------------------------
  458-  482 (36.09/29.21)	DNNllGKFELSGIPPAPRGVPQITV
  487-  509 (36.91/23.36)	DAN..GILNVSAEDKTTGQKNKITI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.95|      29|     189|     170|     200|       5
---------------------------------------------------------------------------
  170-  200 (41.67/32.17)	GLNVMRIINePTaAAIAYGLD.KKATSVGEKN
  362-  391 (47.28/27.61)	GKELCKSIN.PD.EAVAYGAAvQGAILSGEGN
---------------------------------------------------------------------------


Explaination for Stockholm format The "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space.

#=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00)

#=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column. It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column. This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.

#=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.

Alignment of MDP31322 with Med37 domain of Kingdom Viridiplantae



     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KDEIEKMVQEAEKYKSEDEEHKKKVEAKNA
2) MYQGAGGEAGGPGASGMDDDAPPASGGAGPKIEEVD
518
616
547
651










Molecular Recognition Features






MoRF SequenceStartStop




1) GPKIEEVD
644
651