<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31320

Description Probable mediator of RNA polymerase II transcription subunit 37c
SequenceMAGKGEGPAIGIDLGTTYSCVGVWQHDRVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPTNTVFDAKRLIGRRYSDPSVQADKSHWPFKVVSGPGEKPMIVVNHKGEEKQFSAEEISSMVLIKMREIAEAFLGSPVKNAVVTVPAYFNDSQRQATKDAGVISGLNVMRIINEPTAAAIAYGLDKKASSVGEKNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRMVNHFVQEFKRKNKKDITGNPRALRRLRTACERAKRTLSSTAQTTIEIDSLFEGIDFYTTITRARFEELNMDLFRKCMEPVEKCLRDAKMDKSSVHDVVLVGGSTRIPKVQQLLQDFFNGKELCKSINPDEAVAYGAAVQAAILSGEGNEKVQDLLLLDVTPLSLGLETAGGVMTVLIPRNTTIPTKKEQIFSTYSDNQPGVLIQVYEGERARTKDNNLLGKFELSGIPPAPRGVPQITVCFDIDANGILNVSAEDKTTGQKNKITITNDKGRLSKEEIEKMVQEAEKYKAEDEEHKKKVDAKNALENYAYNMRNTIKDEKIASKLDAADKKKIEDAIDQAIEWLDGNQLAEADEFEDKMKELESLCNPIIARMYQGAGPDMGGAGGMDDDTPAGGSGGAGPKIEEVD
Length650
PositionUnknown
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.06
Grand average of hydropathy-0.434
Instability index32.76
Isoelectric point5.14
Molecular weight71100.63
Publications
PubMed=10907853
PubMed=11130713
PubMed=27862469
PubMed=14593172
PubMed=11599561
PubMed=11402207
PubMed=11807141
PubMed=15805473
PubMed=17272265
PubMed=18065690
PubMed=19704521
PubMed=20028838
PubMed=22021418
PubMed=28004282

Function

Annotated function In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions (Probable). ATP-dependent molecular chaperone that assists folding of unfolded or misfolded proteins under stress conditions. Mediates plastid precursor degradation to prevent cytosolic precursor accumulation, together with the E3 ubiquitin-protein ligase CHIP. Recognizes specific sequence motifs in transit peptides and thereby led to precursor degradation through the ubiquitin-proteasome system. Plays a critical role in embryogenesis. In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions. 
ECO:0000269	PubMed:20028838
ECO:0000305	PubMed:11402207
ECO:0000305
GO - Cellular Component
cell wall	GO:0005618	IDA:TAIR
cytoplasm	GO:0005737	IBA:GO_Central
cytosol	GO:0005829	IDA:TAIR
Golgi apparatus	GO:0005794	IDA:TAIR
mitochondrion	GO:0005739	IDA:TAIR
nucleus	GO:0005634	IEA:UniProtKB-SubCell
plasma membrane	GO:0005886	IDA:TAIR
vacuolar membrane	GO:0005774	IDA:TAIR
GO - Biological Function
ATP binding	GO:0005524	IDA:TAIR
ATPase activity	GO:0016887	IBA:GO_Central
heat shock protein binding	GO:0031072	IBA:GO_Central
misfolded protein binding	GO:0051787	IBA:GO_Central
protein folding chaperone	GO:0044183	IBA:GO_Central
ubiquitin protein ligase binding	GO:0031625	IPI:UniProtKB
unfolded protein binding	GO:0051082	IBA:GO_Central
GO - Biological Process
cellular response to unfolded protein	GO:0034620	IBA:GO_Central
chaperone cofactor-dependent protein refolding	GO:0051085	IBA:GO_Central
protein refolding	GO:0042026	IBA:GO_Central
protein ubiquitination	GO:0016567	IMUniProtKB
response to bacterium	GO:0009617	IETAIR
response to cadmium ion	GO:0046686	IETAIR
response to heat	GO:0009408	IEUniProtKB
response to temperature stimulus	GO:0009266	IETAIR
response to virus	GO:0009615	IETAIR

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31320
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.61|      25|      41|     511|     535|       1
---------------------------------------------------------------------------
  511-  535 (40.65/28.12)	NDKGRLSKEEIEKMVQEAEKYKAED
  554-  578 (39.96/27.52)	NMRNTIKDEKIASKLDAADKKKIED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.03|      45|     189|     170|     218|       2
---------------------------------------------------------------------------
  170-  218 (62.42/54.19)	GLNVMRIINePTaAAIAYGLDKKASSV.GEKNVLIFDLggGTFDVSLLTI
  362-  407 (71.61/45.39)	GKELCKSIN.PD.EAVAYGAAVQAAILsGEGNEKVQDL..LLLDVTPLSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.19|      18|      21|      38|      55|       3
---------------------------------------------------------------------------
   16-   33 (19.09/ 9.17)	....TTYSCVGVWQHDRveIIA
   38-   55 (32.57/20.02)	NR..TTPSYVAFTDSER..LIG
   60-   78 (24.54/13.56)	NQvaMNPTNTVF.DAKR..LIG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31320 with Med37 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAGPDMGGAGGMDDDTPAGGSGGAGPKIEEVD
2) KEEIEKMVQEAEKYKAEDEEHKKKVDAKNA
619
518
650
547










Molecular Recognition Features






MoRF SequenceStartStop




1) GAGPKIEEVD
2) IARMY
641
613
650
617