<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31319

Description Probable mediator of RNA polymerase II transcription subunit 37b
SequenceMIFIKENTAKMTRNKAIACLVFLTVLDFLMNIGAALMSSLAIEGEEQKLGTVIGIDLGTTYSCVGVYHNKHVEIIANDQGNRITPSWVAFTDTERLIGEAAKNQAAKNPERTIFDPKRLIGRKFDDPDVQRDIKFLPYKVVNKDGKPYIQVKVKGEEKLFSPEEISAMILTKMKETAEAFLGKKIKDAVITVPAYFNDAQRQATKDAGAIAGLNVVRIINEPTGAAIAYGLDKKGGESNILVYDLGGGTFDVSILTIDNGVFEVLSTSGDTHLGGEDFDHRVMDYFIKLVKKKYNKDISKDHKALGKLRRECELAKRSLSNQHQVRVEIESLFDGVDFSEPLTRARFEELNMDLFKKTMEPVKKALKDAGLKKSDIDEIVLVGGSTRIPKVQQMLKDFFDGKEPSKGTNPDEAVAYGAAVQGGVLSGEGGEETQNILLLDVAPLSLGIETVGGVMTNIIPRNTVIPTKKSQVFTTYQDQQTTVTINVYEGERSMTKDNRELGKFDLTGILPAPRGVPQIEVTFEVDANGILQVKAEDKVAKTSQSITITNDKGRLTEEEIEEMIREAEEFAEEDKIMKEKIDARNKLETYVYNMKSTVADKEKLAKKISDEDKEKMEGVLKEALEWLEENVNAEKEDYDEKLKEVELVCDPVIKSVYEKTEGENEDDDGDDHDEL
Length675
PositionUnknown
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.06
Grand average of hydropathy-0.443
Instability index36.95
Isoelectric point4.95
Molecular weight75148.58
Publications
PubMed=12853141
PubMed=11130712
PubMed=27862469
PubMed=11599561
PubMed=11402207
PubMed=21482766
PubMed=22021418
PubMed=23624714
PubMed=24486762
PubMed=26186593
PubMed=26251880

Function

Annotated function In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions (Probable). Required for pollen development and pollen tube growth (PubMed:24486762). May be required for the early stages of female gametophyte development, but not for polar nuclei fusion during female gametophyte (PubMed:26251880). Possesses ATPase activity in vitro (PubMed:26186593). 
GO - Cellular Component
cytoplasm	GO:0005737	IBA:GO_Central
endoplasmic reticulum chaperone complex	GO:0034663	IBA:GO_Central
endoplasmic reticulum lumen	GO:0005788	IBA:GO_Central
mediator complex	GO:0016592	IDA:UniProtKB
membrane	GO:0016020	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central
secretory vesicle	GO:0099503	HDA:TAIR

GO - Biological Function
ATP binding	GO:0005524	IBA:GO_Central
ATPase activity	GO:0016887	IBA:GO_Central
heat shock protein binding	GO:0031072	IBA:GO_Central
misfolded protein binding	GO:0051787	IBA:GO_Central
protein folding chaperone	GO:0044183	IBA:GO_Central
unfolded protein binding	GO:0051082	IBA:GO_Central

GO - Biological Process
cellular response to unfolded protein	GO:0034620	IBA:GO_Central
chaperone cofactor-dependent protein refolding	GO:0051085	IBA:GO_Central
endoplasmic reticulum unfolded protein response	GO:0030968	IBA:GO_Central
pollen tube growth	GO:0009860	IETAIR
protein refolding	GO:0042026	IBA:GO_Central
response to singlet oxygen	GO:0000304	IMTAIR
ubiquitin-dependent ERAD pathway	GO:0030433	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31319
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.10|      18|      21|     110|     130|       1
---------------------------------------------------------------------------
  111-  129 (29.29/19.52)	RTI.FDPKRLIGRKfDDPDV
  131-  149 (26.81/12.32)	RDIkFLPYKVVNKD.GKPYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.33|      11|      21|     612|     622|       2
---------------------------------------------------------------------------
  612-  622 (18.58/11.18)	DKEKMEGVLKE
  634-  644 (18.75/11.35)	EKEDYDEKLKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.20|      44|     289|     190|     235|       3
---------------------------------------------------------------------------
  190-  235 (67.84/48.07)	ITVPAYfnDAQRQATKDAGAIAGLNVVRIINEPTGAA...IAYGLDKKG
  483-  529 (70.36/43.38)	VTINVY..EGERSMTKDNRELGKFDLTGILPAPRGVPqieVTFEVDANG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31319 with Med37 domain of Kingdom Viridiplantae
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