<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31315

Description Mediator of RNA polymerase II transcription subunit 33B
SequenceMAPSEFQPSLWESVTSLIRSAQEKNVDPLHWALQLRLTLASAGISLPSPDLAQFLVTHIFWENHSPLSWKLLEKAISVNIVPPLLVLALLSPRVIPNRKLHPAAYRLYMELLKRHAFSFMPLIRAPGYHKTMNSIDDILHLSETFGVQDQEPGSILLAFVFSIVWELLDASLDEEGLLELTSNKRSKWPSSPHDMDLDGLENSVKRNENHDALEKANTEMAIELIQEFLQNKVTSRILHLASQNMESKTIPRGEFHAIVSSGSKLALTSDSALWLPIDLFFEDIMDGTQAAAASAVENLTGLVKALQAANSTSWHDAFLALWLAALRLVQRENLCLRYCFFMHMLEILSEERDPIEGPVPRTDTFLCVLLSVTPLAVANIIEEEESQWIDQTSSSPSNQWKEKKGKCRQGLINSLQQLGDYESLLTPPRSVQSVANQAAAKAIMFISGITNSNGSYENTSMSESASGCCKVRFSLFTLKMFVVMGVYLLCNISCWSLVMKGSPLTPSLTNSLITTPASSLAEIEKMYEVATTGSEDEKIAVASILCGASLFRGWSIQEHVIIFIVTLLSPPAPADLSGSYSHLINSAPFLNVLLVGISPIDCVHIFSLHGVVPLLAGALMPICEAFGSGVPNITWTLPTGELISSHAVFSTAFTLLLRLWRFDHPPLDYVLGDVPPVGPQPSPEYLLLVRNCRLECFGKSPKDRMARRRFSKVIDISVDPIFMDSFPRLKQWYRQHQECMASILSELKTGSPVHHIVDSLLSMMFKKANKGGSQSLTPSSGSSSLSTSGGDDSSDQLKLPAWDILEAAPFVLDAALTACAHGSLSPRELATGLKILADFLPATLGTMVSYFSSEVTRGLWKPVSMNGTDWPSPAANLASVEQQIEKILAATGVDVPRLPADGISAATLPLPLAALVSLTITYKLDKATERFLVLVGPALDSLAAACPWPCMPIVTSLWTQKVKRWSDFLIFSASRTVFHHNRDAVIQLLRSCFTCTLGLTPTSQLCSYGGVGALLGHGFGSRYSGGISTAAPGILYIKVHRSIRDVMFLTEEILSLLMFSVKSIATRELPAGQAEKLKKTKDGSRYGIGQVSLSLAMRRVKLAASLGASLVWISGGLNLVQALIKETLPSWFISVHGEEDELGGMVPMLRGYALAYFAILSSAFAWGVDSSYPASKRRPRVLWLHLEFMVSALEGKISLGCDWATWQAYVTGFVSLMVQCTPAWVLEVDVEVIKRLSKSLRQWNEQDLALALLCAGGLGTMGAATELIVETCHQH
Length1275
PositionTail
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.08
Grand average of hydropathy0.175
Instability index50.13
Isoelectric point6.06
Molecular weight139561.98
Publications
PubMed=27862469
PubMed=10617197
PubMed=8709959
PubMed=17560376
PubMed=18430946
PubMed=22021418
PubMed=22167189

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Involved in the repression of phenylpropanoid biosynthesis. May compete with MED33B for common binding partners or for occupancy in Mediator. 
ECO:0000269	PubMed:18430946
ECO:0000269	PubMed:22167189
GO - Cellular Component
mediator complex	GO:0016592	IDA:UniProtKB
membrane	GO:0016020	TAS:TAIR
GO - Biological Function
GO - Biological Process
phenylpropanoid metabolic process	GO:0009698	IMTAIR
regulation of phenylpropanoid metabolic process	GO:2000762	IGI:TAIR









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31315
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.82|      63|     103|     532|     601|       1
---------------------------------------------------------------------------
  532-  601 (92.82/80.28)	TGsedEKIAVASILCGA..SLFRGWSIQEHVIIFIVTLLSPPAPADlSGSYSHLINSApflNVLLVGISPID
  639-  703 (110.00/72.26)	TG...ELISSHAVFSTAftLLLRLWRFDHPPLDYVLGDVPPVGPQP.SPEYLLLVRNC...RLECFGKSPKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.32|      32|     222|     754|     790|       2
---------------------------------------------------------------------------
  754-  790 (45.33/36.28)	HHIVDSLLSMMfkKANKGGSQSLTPssgSSSLSTSGG
  979- 1010 (59.99/33.08)	HHNRDAVIQLL..RSCFTCTLGLTP...TSQLCSYGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.42|      11|     136|     800|     810|       4
---------------------------------------------------------------------------
  800-  810 (23.37/12.49)	PAWDILEAA.PF
  937-  948 (18.05/ 7.96)	PALDSLAAAcPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.65|      16|     139|    1036|    1054|      14
---------------------------------------------------------------------------
  128-  143 (29.60/17.30)	YHKTMNSIDDILHLSE
 1036- 1051 (29.05/27.08)	YIKVHRSIRDVMFLTE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31315 with Med33 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA