<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31312

Description Probable mediator of RNA polymerase II transcription subunit 26b
SequenceMKASGSLDSWREYFRRRGDSDIFGIIDHAIMVAATDCPNKFKSRRDKIAELLFSCRVNRCVGCDHLELSVPGDDEANRGTTGNGGGGTAVDEDYEVAGGSKESKANSSRGDNNQIVSNYTFDEAEALSDEIEEFSVVSKEVARIKEILLNKEDEPNSVLLDSLRHLKLMSLNVDILKSTEIGKAVNGLRKHSSDKIRQLAKTLIAEWKELVDQWVNTTKEITGAEGTPESANPSVLDEEEAFPSLPYDVDIFTPEPNGFEISHFFDSLDFDGNPRNSEEHNTSREHERRPQNIAKRKPEGTQMRIQDAPFRSIKPSSATDFDGTRRPVKQSTEQRMKNETVSVHKSEKPMIQRKPVVTEQKRKAPGPQQEKLKGLDADAKFEFAKRKLQESYQHHENAKKQRTIQVLEMIPKQGSAQKPQLKRPGMSNRNWANGRK
Length436
PositionUnknown
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.06
Grand average of hydropathy-0.917
Instability index49.67
Isoelectric point6.60
Molecular weight49134.33
Publications
PubMed=10470850
PubMed=27862469
PubMed=14593172
PubMed=22021418

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). May play a role in transcription elongation (By similarity). 
ECO:0000250
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell
GO - Biological Function
translation elongation factor activity	GO:0003746	IEA:UniProtKB-KW
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31312
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     163.15|      45|      48|     265|     311|       1
---------------------------------------------------------------------------
  225-  260 (36.98/17.63)	......EGTP......ESANPSvldEE....EafP.SLPYDVDIFTPEPN........GFE
  265-  311 (79.25/51.03)	FDSLDFDGNPR...NSEEHNTS...RE....H..E.RRPQNIAKRKPEGT.QMRiqDAPFR
  316-  365 (46.92/24.21)	SSATDFDGTRRpvkQSTEQRMK...NEtvsvH..KsEKP..MIQRKPVVTeQKR..KAP..
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31312 with Med26 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HFFDSLDFDGNPRNSEEHNTSREHERRPQNIAKRKPEGTQMRIQDAPFRSIKPSSATDFDGTRRPVKQSTEQRMKNETVSVHKSEKPMIQRKPVVTEQKRKAPGPQQEKLKGLDADAKFEFAKRKLQESYQHHENAKKQRTIQVLEMIPKQGSAQKPQLKRPGMSNRNWANGRK
2) PGDDEANRGTTGNGGGGTAVDEDYEVAGGSKESKANSSR
263
71
436
109










Molecular Recognition Features






MoRF SequenceStartStop




1) LDADAKFEFAK
2) LPYDVDIFTPEPNGFEISHFFD
3) TIQVLEMIPKQGSAQKPQLKRPGMSNRNWANGRK
4) WREYFRRR
375
245
403
10
385
266
436
17