<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31311

Description Probable mediator of RNA polymerase II transcription subunit 26a
SequenceMAKMRPSVSLDTWREYFRRGDSDIFGIIDHAIMVAAADWPKEFKSRSDRIAELLFSCKVSRCIGCDHLELSIAGDEAAVEIVGVGGGGDRGDSGVATGEGEEASVSVDEVMRIRDILSNKDDEKDSVLLESLRKLESMSMSVDILKDTEIGKAVNGLRRHSSDKISKLAKTLFAEWKRLVDQWMNTPEEMAGTEGTPESLNLSVIDEEEAFPSPPHDLDIYAPEPNGFELSQILDCLDCDGNPRHSVESKHERKSQSSAGRRPKGTNDANVVGRYCNDQQTRREEADVRPMKHSATDVVEPKRQTKQSREQMVSAIQRKPTAVTEQKRKLAGPQQDKLKALDPDSKFEFAKRKLQESYHQHENAKRQRTIQVLETIPKQNKVQKPQLKRPATRRYIYWYFWSSEFPGYELPSLILNLANPRDSSSQFSRHDELMIDIPVYFGLVLVQIDKAEMVDEMMIFKKMSVLLTEKDFVDAIVSVSLKDLTRSLFVRFEAKACPKFDLIHKTSVETVRCVGKTFMHMLSKVSREFPPRNRTHPGGLLYQRFDPTHLSLARQQVAICKETDSQYPHEIVIHWTSASA
Length580
PositionUnknown
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.07
Grand average of hydropathy-0.584
Instability index50.02
Isoelectric point6.50
Molecular weight65871.10
Publications
PubMed=11130713
PubMed=27862469
PubMed=22021418

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). May play a role in transcription elongation (By similarity). 
ECO:0000250
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell
GO - Biological Function
translation elongation factor activity	GO:0003746	IEA:UniProtKB-KW
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31311
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.86|      20|      22|     285|     304|       1
---------------------------------------------------------------------------
  285-  304 (34.70/25.47)	EADVRPMKHSATDVVEPKRQ
  310-  329 (33.16/24.01)	EQMVSAIQRKPTAVTEQKRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.42|      23|      27|     197|     219|       3
---------------------------------------------------------------------------
  197-  219 (40.65/26.72)	PESLNLS.VIDEEEAFPSPPHDLD
  225-  248 (38.78/25.16)	PNGFELSqILDCLDCDGNPRHSVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.91|      21|      21|      64|      84|       6
---------------------------------------------------------------------------
   64-   84 (35.06/24.74)	GCDHLELSIAGDEAAVEIVGV
   87-  107 (34.84/24.55)	GGDRGDSGVATGEGEEASVSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31311 with Med26 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CDGNPRHSVESKHERKSQSSAGRRPKGTNDANVVGRYCNDQQTRREEADVRPMKHSATDVVEPKRQTKQSREQMVSAIQRKPTAVTEQKRKLAGPQQDKLKALDPDS
2) KRKLQESYHQHENAKRQRTIQVLETIPKQNKVQKP
239
351
345
385










Molecular Recognition Features






MoRF SequenceStartStop




1) ATRRYIYWYFWSSE
2) HDLDIY
391
216
404
221