<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31305

Description Probable mediator of RNA polymerase II transcription subunit 19b
SequenceMESESVKFGGPRELGGALDLITQYKLLPHHEFFCKRSLPESLSDAHYLHNLVGDTEIRKGEGMQLDQLIPNASLSSRDTNARIQPFVLDELKEAFELNDTAPVELPPAEKGAPTTVSKSKSESKDKDRKHRKHKDKKEKDREHKKHKHKHKDRIKDKDKDKDRDKKKEKSGHHDKKRKNNGTEDADDVQRHKKSKHKSSKLDEMGAM
Length207
PositionHead
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.03
Grand average of hydropathy-1.480
Instability index35.11
Isoelectric point9.36
Molecular weight23823.55
Publications
PubMed=11130714
PubMed=27862469
PubMed=14593172
PubMed=22021418

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IBA:GO_Central
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31305
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.89|      20|      21|     134|     153|       1
---------------------------------------------------------------------------
  134-  153 (39.78/15.97)	KDK.KEKDREHKKHKHKHKDR
  155-  175 (32.11/11.60)	KDKdKDKDRDKKKEKSGHHDK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31305 with Med19 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNLVGDTEIRKGEGMQLDQLIPNASLSSRDTNARI
2) LNDTAPVELPPAEKGAPTTVSKSKSESKDKDRKHRKHKDKKEKDREHKKHKHKHKDRIKDKDKDKDRDKKKEKSGHHDKKRKNNGTEDADDVQRHKKSKHKSSKLDEMGAM
49
97
83
207










Molecular Recognition Features






MoRF SequenceStartStop




1) EMGAM
2) KDKDRKHRKHKDKKEKDREHKKHKHKHKDRIKDKDKDKDRDKKKEKSGHHDKKRKN
203
124
207
179