<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31302

Description Probable mediator of RNA polymerase II transcription subunit 15c
SequenceMEGNTNWKPNEQGGNRDAANNRIDWRSQHEPELRQKVLSKIVEKFKEKFHAHEEYKINDIASKFEENFYSIATDKTTTSQQWLQQNTQSNLCVICFAKSGPYNRSRFSKTDTCSVTAAATSSAKFVETTYSTAFSSIKLTKHSITDQKSVFDTTEQKRQEQEQLINQLTNLPTSRPNNRDQQGAFQVSSSQQNNNVTLHAMSQQKNNLQSMTRGQQVGQSQPMMSQQYRQQYPMQQDPQNRNLQKHLDFVQNNTNQFQAASSLRQTQNITDQQNQPQQLERANPSILIMNIIVASQDSTGKTVNVNAGNWQEETYQKIKKLKEMCLPVLSLMHQRVAEKLRETESLPPQPMQAQWIEKLKAGKLSMEHLMFFLNVHRSSVSEKHRDKFSQYEYHILKFTKSQTMVLRPTQQQQGQFPPSQTAMQTQSPQVHVSQSLYKEQRRSRLMPSSQNEASSLLQIRPKLDPRDENIIMASSGNVMLPSVKQNPRAVNTNISSVQSLQKQKRFHHRQMQQQQPQQGNHQHQMQTNEMNDVRMRERVNIKARLLEQQVSSSQRQVPKQESNVSSSQIQNHSSPQLVDQHILPATINKTGTPLNSSGSAFVAPAPSPVPGDSEMPISVESPVSGVDEINSTLDSSSKLGTQETPLLFVPPPEPITERPIDRLIKAFQAASPKSLAESVSEISSVISMVDMIGGSFPSSGGSRAGLGEDLSERTRNFTTHEETNLSKRMKRSINIVPPDMSSQIDSYEQLSSLESEVVSTTSSGLKVNNIAPGYALLQEIKETNGRLVETVVEICDEDSLGTIVTCTYAPVALSATFKDHYKSGKIIFYVSKCLMQAQIQPLRLLFPMDYPYSSPIVLEEISFDTSVHKYEDLSARTRSRFSLSMKEFSEPGFSKGIAQTWNDCARATMVEYAERHGGGTFSSKYGAWETVLRAS
Length935
PositionTail
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.06
Grand average of hydropathy-0.736
Instability index61.98
Isoelectric point8.84
Molecular weight105505.13
Publications
PubMed=10617197
PubMed=27862469
PubMed=22021418

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell
GO - Biological Function
chromatin DNA binding	GO:0031490	IDA:TAIR
transcription coactivator activity	GO:0003713	IEA:InterPro
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31302
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     275.47|      43|     145|     244|     286|       1
---------------------------------------------------------------------------
  141-  177 (37.60/12.77)	.KH...SITDQKSVFDT...................TEQ....KRQEQE.......Q...LINQ..LTN..LPTSR.............PN.
  179-  215 (24.88/ 6.14)	........RDQQGAFQV...................SSS.....QQNNNVTlhamsQ...QKNN..LQS..MTRGQ................
  244-  286 (72.27/30.83)	QKHLD.FVQNNTNQFQA...................ASS....LRQTQNIT.....D...QQNQ..PQQ..LERAN.............PSI
  304-  362 (34.35/11.07)	NVNAG.NWQEET..YQKikklkemclpvlslmhqrvAEK....LRETESLP.....P...QPMQ..AQW..IEKLK.............AG.
  382-  430 (41.38/14.74)	EKHRDkFSQYEYHILKF...................TKSqtmvLRPTQ........Q...QQGQfpPSQtaMQTQS.............PQV
  440-  483 (31.84/ 9.76)	QRRSR.LMPSSQNE......................ASS....LLQIR..................P.K..LDPRDeniimassgnvmlPSV
  484-  518 (33.14/10.45)	KQNPR.AV..NTN.ISS...................VQS....LQKQKRFH.....HrqmQQQQ..PQQ.......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     269.38|      64|      64|     577|     640|       2
---------------------------------------------------------------------------
  561-  609 (52.66/27.97)	..........ESNVS............S..SQIQnhsspqLVDQHILPATINKTGTPLNSSGSAFVAPAPSPV
  610-  675 (89.83/53.13)	PGDSEMPISVESPVSGVD.EINSTLDSS..SKLGtqetplL....FVPPPEPITERPIDRLIKAFQAASPKSL
  676-  736 (76.11/43.85)	.AESVSEIS..SVISMVD.MIGGSFPSSggSRAG......LGED..LSERTRNFTTHEETNLSKRMKRSINIV
  737-  787 (50.78/26.70)	PPDMSSQIDSYEQLSSLEsEVVSTTSSG..LKVN.....nIAPGYALLQEIKETNGRL...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.96|      10|      16|      41|      50|       3
---------------------------------------------------------------------------
   41-   50 (18.41/12.69)	IVEKFKEKFH
   60-   69 (18.55/12.85)	IASKFEENFY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.71|      12|      16|       6|      17|       4
---------------------------------------------------------------------------
    6-   17 (23.11/14.25)	NWKPNEQGGNRD
   24-   35 (22.60/13.75)	DWRSQHEPELRQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31302 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LRPTQQQQGQFPPSQTAMQTQSPQVHVSQSLYKEQRRSRLMPSSQNEASSLLQIRPKLDPRDENIIMASSGNVMLPSVKQNPRAVNTNISSVQSLQKQKRFHHRQMQQQQPQQGNHQHQMQTNEMNDVRMRERVNIKARLLEQQVSSSQRQVPKQESNVSSSQIQNHSSPQLVDQHILPATINKTGTPLNSSGSAFVAPAPSPVPGDSEMPISVESPVSGVDEINSTLDSSSKLGTQETPLLFVPPPEPI
2) TDQKSVFDTTEQKRQEQEQLINQLTNLPTSRPNNRDQQGAFQVSSSQQNNNVTLHAMSQQKNNLQSMTRGQQVGQSQPMMSQQYRQQYPMQQDPQNRNLQKHLDFVQNNTNQFQAASSLRQTQNITDQQNQPQQLER
406
145
655
281










Molecular Recognition Features






MoRF SequenceStartStop




1) RPIDRLIKAF
658
667