<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31300

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMDNNNWRPSLPNGEPAMDTGDWRTQLPPDSRQKIVNKIMETLKKHLPFSGPEGINELRRIAARFEEKIFSGALNQTDYLRKISMKMLTMETKSQNAAGSSAAIPAANNGTSIDSIPTNQGQLLPGSLSTNQSQAPQPLLSQTMQNNTASGMTGSTALPSSMPPVSSITNNNTTSVVNQNANMQNVAGMLQDSSGQHGLSSNMFSGPQRQMLGRPHAMSSQQQQQPYLYQQQLQQQLLKQNFQSGNVPNPNSLLPSHIQQQQQNVLQPNQLHSSQQPGVPTSATQPSTVNSAPLQGLHTNQQSSPQLSSQQTTQSMLRQHQSSMLRQHPQSQQASGIHQQQSSLPQQSISPLQQQPTQLMRQQAANSSGIQQKQMMGQHVVGDMQQQHQQRLLNQQNNVMNIQQQQSQQQPLQQPQQQQKQQPPAQQQLMSQQNSLQATHQNPLGTQSNVAGLQQPQQQMLNSQVGNSSLQNNQHSVHMLSQPTVGLQRTHQAGHGLYSSQGQQSQNQPSQQQMMPQLQSHHQQLGLQQQPNLLQQDVQQRLQASGQVTGSLLPPQNVVDQQRQLYQSQRTLPEMPSSSLDSTAQTESANGGDWQEEVYQKIKSMKETYLPDLNEIYQRVAAKLQQDSMPQQQRSDQLEKLRQFKTMLERMIQFLSVSKSNIMPALKDKVAYYEKQIIGFLNMHRPRKPVQQGQLPQSQMQPMQQPQSQTVQDQSHDNQTNPQMQSMSMQGAGPRAQQSSMTNMQSNVLSSRPGVSAPQQNIPSSIPASSLESGQGNTLNNGQQVAMGSMQQNTSQLVNNSSASAQSGLSTLQSNVNQPQLSSSLLQHQHLKQQQDQQMQLKQQFQQRQMQQQQLQARQQQQQQQLQARQQAAQLQQMNDMNDLTSRQGMNVSRGMFQQHSMQGQRANYPLQQLKPGAVSSPQLLQGASPQMSQHLSPQVDQKNTVNKMGTPLQPANSPFVVPSPSSTPLAPSPMQVDSEKPGSSSLSMGNIARQQATGMQGVVQSLAIGTPGISASPLLQEFTSPDGNILNSSTITSGKPSATELPIERLIRAVKSISPQALSSAVSDIGSVVSMVDRIAGSAPGNGSRASVGEDLVAMTKCRLQARNFMTQEGMMATKKMKRHTTAMPLSVASLGGSVGDNYKQFAGSETSDLESTATSDGKKARTETEHALLEEIKEINQRLIDTVVEISDDEDAADPSEVAISSIGCEGTTVRFSFIAVSLSPALKAHLSSTQMSPIQPLRLLVPCSYPNGSPSLLDKLPVETSKENEDLSSKAMARFNILLRSLSQPMSLKDIAKTWDACARAVICEYAQQFGGGTFSSKYGTWEKYVAAS
Length1335
PositionTail
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.03
Grand average of hydropathy-0.767
Instability index71.58
Isoelectric point9.27
Molecular weight146343.93
Publications
PubMed=11130712
PubMed=27862469
PubMed=17560376
PubMed=22021418

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IDA:UniProtKB
nucleus	GO:0005634	IDA:TAIR

GO - Biological Function
chromatin DNA binding	GO:0031490	IDA:TAIR
transcription coactivator activity	GO:0003713	IDA:TAIR

GO - Biological Process
positive regulation of fatty acid biosynthetic process	GO:0045723	IMTAIR
response to salicylic acid	GO:0009751	IMTAIR









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31300
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|     992.07|     109|     110|     690|     798|       3
---------------------------------------------------------------------------
   83-  159 (65.78/10.27)	..................................................................SM....KMLTM....ETKSQNA..AGSSA.......AIPAANNGTS.......idS.IPT...................NQG.....Q...LLPG..................S........LS......TNQ....S...Q.......A..P.QPLLSQT....MQN.N.TASGM..............TGSTALPS
  160-  321 (89.43/16.99)	SMppvssiTN.....NNTT.SVV......NQ.....NA.........NM..QNV......AG....ML....QDSSG....QHGLSSNMFSGPQRqmlgrphAMSSQQQQQPylyqqqlqqQ.LLKqnfqsgnvpnpnsllpshiQQQ.....QqnvLQPN..................Q........LH......SSQ....Q...PgvptsatQ..P.STVNSAPlqglHTNqQ.SSPQLS.SQ......QTTQSMLRQHQS
  322-  457 (74.62/12.78)	SM...............LR.QHPqsqqasGIhqqqsSL.........PQ..QSIsplqqqPT....QLmrqqAANS......SGIQQKQMMGQHV........VGDMQQQHQ.........QrLLN...................QQNnvmniQ...QQQSqqqplqqpqqqqkqqppaQ........QQ......LMS....Q...Q.......N..SlQATHQNP....LGT.Q.SN................VAGLQQPQQ
  458-  544 (83.73/15.37)	QM......LN....SQV............GN.....SS.........LQ..NNQ......HSvhmlSQ....PTVGLqrthQAGHGLYSSQGQQ..................................................................S..................Q........NQ......PSQ....QqmmP.......Q......LQ..S....HHQ.Q.LGLQQQpNL......LQQDVQQRLQAS
  550-  644 (102.30/20.65)	SL......LP..PQ.NVVD.QQR......QL.....YQ.........SQ..RTL......PE.....M....PSSSL....DSTAQTESANG............GDWQEEVY.........Q.KIK.................smKET.....Y...LPDL..................N.........E......IYQ....R...V.......A..A.KLQQDSM....PQQ.Q.RSDQLE.KL.............R.QFK
  645-  738 (139.30/31.18)	TM......LE..RMIQFLSvSKS.............................NI......MP....AL....K.............DKVAYYEKQ.......IIGFLNMHRP.........R.KPV...................QQG.....Q...LPQS..................Q........MQ......PMQ....Q...P.......Q..S.QTVQDQS....HDN.Q.TNPQMQ.SM......SMQGAGPRAQQS
  739-  844 (145.51/32.94)	SM......TN..MQSNVLS.SRP......GV.....SA.........PQ..QNI......PS....SI....PASSL....ESGQGNTLNNGQQV.......AMGSMQQNTS.........Q.LVN...................NSS.....A...SAQS..................G........LS......TLQsnvnQ...P.......QlsS.SLLQHQ.....HLK.Q...QQDQ.QM......QLK......QQF
  845-  930 (85.32/15.82)	QQ......RQ..MQQQQLQ.ARQ.............QQ.........QQ..QQL......QA....RQ....QAAQL...............QQ.........MNDMNDLTS........rQ.GMN..................vSRG.....M...FQQH..................S........MQgqranyPLQ....Q...L.......K..P.GAV..............SSPQL...........LQGASPQ....
  931-  997 (76.72/13.38)	............M.SQHLS...P......QV.....D...........Q..KNT......VN....KM.................GTPL..................QPANS.........P.FVV..................pSPS.....S...TPLA..................P.........S......PMQ.......................V..........D.S.EKPGSS.SL......SM.GNIARQQAT
  998- 1093 (65.61/10.22)	GM......QG..VVQSLAI.GTP......GI.....SAspllqeftsPD..GNI......LN....S.......STI....TSGKPSA....TEL.......PIERLIRA........................................................................................................vK..S.ISPQALS....SAV.S.DIGSVV.SMvdriagSAPGNGSRASVG
 1098- 1209 (63.76/ 9.69)	AM......TKcrLQARNFM.TQE......GM.....MA.........TKkmKRH......TT....AM....PLSVA....SLG.GSVGDNYKQF.......A.GS...ETS.........D.LES................tatSDG.....K...KART..................EtehalleeIK......EIN....Q...R.......L..I.DTVVEIS....DDE.DaADPSEV.AI......SSIG........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.47|      15|      19|       1|      19|       4
---------------------------------------------------------------------------
    5-   19 (30.81/29.71)	NWRPSLPNG......EPAMDT
   21-   41 (23.65/ 8.57)	DWRTQLPPDsrqkivNKIMET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.77|      13|      20|      48|      60|       5
---------------------------------------------------------------------------
   48-   60 (24.26/16.39)	FSGP.EGINELRRI
   69-   82 (19.50/11.51)	FSGAlNQTDYLRKI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31300 with Med15 domain of Kingdom Viridiplantae
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