<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31299

Description Mediator of RNA polymerase II transcription subunit 13-like
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYDKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHLHMAQSSPAPFQVLVSPYGLNGTLTGHAYKMSDPAARKLIEEWHCFYPMVLRKREEPREEAELGYDDDFPVAVEVIVGGVRMVYPSAFVLVSQNDIPVPQSGHGTVAQQGLGSVKDPSNCGMPLTPPTSPEQVVIGESGGVQSAASHLGSQDGGMSTMHSPKRSRKTPPKLHSHMVRRVWRECILSRAQSKRSQMSTPTREEEAAHSPAAWDFVDPTQRVSCSCSRHKLLKRCAVGPSRPPAISQPGFSAGLPSSSSLPPPASSKHKTTERQEKGDKLQKRPLVPFHHRPSVAEELCVEQDAPGQKLGLAGIDASLEVSNTRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQEAESLDPPSVPVNPALYGNGLDLQQLSTIEDRTVLVGQRLPLMAEASETALYSGLRPSYTESSDRWWQSFRLPSSEDAEFRPPELQGERFDTALDLNPESTALQRLLAQPNKRFKIWQDEQPQVQPLPFLDPSPLSQQPGDTLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDSAAGRAGSGSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEERPPGKDGRAAGPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGVSSETVTALGMMESPVVSMVPTHLTEFRMEVEDGLGSPKPEEIKDFSYVHKVPQFQPFVGSSMFAPLKTLPSHCLLPLKTPDACLFRPSWAVPPKMEQLPMPPAASSIRDGYNNVPSVGSLADPDYVNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNVFKDRNFDSCCICACNMNIKGADVGLYIPDSSKEDQYRCTCGFSAIVNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQSSGQSTLLPQVEGARKAPEPPVSLLLLLQNQHTQPFASLSFLDYISSANRHALPCVSWTYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHCWPHSNVLDTSMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKEFLTISPFSLPFWERLLLEPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTEELVSEWFNQPWSSEESDNHSRLKLYAQVCRHHLAPYLATLQLDSGLLMPPKHQSPPAEAQGQATPGNAGSLPSNSGSGAPPAGSAFNPTSSSSANPTTSSSSASSGPPGSSAASAPGITQMNTTSSSGFGGGVGGQNPSAGGSSTDRTPGNVACGDTEPGQSCTQSSQDGQDSVTERERIGIPTEPDSADSHAYPPAVVIYMVDPFTYTAEEDSSSGNFWLLSLMRCYTEMLDHLPEHMRSSFILQIVPCQYMLQTMKDEHVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTEPGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPSRSRKSKVSARKVGLQKLWEWCLGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQARNQCPLFLKASLHHHISVAQTDELLPARTSQRAPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNML
Length2207
PositionMiddle
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.07
Grand average of hydropathy-0.398
Instability index60.94
Isoelectric point5.75
Molecular weight241755.39
Publications
PubMed=15145061
PubMed=16141072
PubMed=12693553
PubMed=15489334
PubMed=21183079

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IDA:MGI
nucleoplasm	GO:0005654	TAS:Reactome
P:transcription by RNA polymerase II	GO:0006366	IMGI

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
transcription by RNA polymerase II	GO:0006366	IC:MGI









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31299
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     158.67|      21|      41|     435|     455|       1
---------------------------------------------------------------------------
  436-  477 (26.56/ 9.29)	PPAIS..QPGFSAG..LPSSSSLPppasskhktterqekgdklqkR
  838-  858 (25.63/ 8.66)	PP..G..KDGRAAGpyPPTVADLQ.....................R
  983- 1004 (27.61/10.00)	PPAASsiRDGYN.N..VPSVGSLA.....................D
 1531- 1549 (28.83/10.83)	PPAEA..Q.GQATP...GNAGSLP.....................S
 1556- 1571 (25.89/ 8.84)	PPAGS.......AF..NPTSSSSA.....................N
 1572- 1591 (24.14/ 7.65)	PTT.S..SSSASSG..PPGSSAAS.....................A
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     164.63|      28|      28|    1029|    1056|       2
---------------------------------------------------------------------------
 1011- 1038 (42.28/18.67)	PQMNTPVTLNSAAPASNSGAGVLPSPAT
 1039- 1066 (48.55/22.67)	PRFSVPTPRTPRTPRTPRGGGTASGQGS
 1595- 1614 (34.87/13.95)	TQMNT.......TSSSGFGGGV.GGQNP
 1615- 1639 (38.93/16.54)	SAGGSS...TDRTPGNVACGDTEPGQSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.79|      27|      28|    2067|    2094|       3
---------------------------------------------------------------------------
 2067- 2094 (41.86/28.10)	HFQhSRSQGERL...LSREAPEELKQQPLAL
 2096- 2125 (45.94/26.01)	YFV.STAKAENLpqwFWSSCPQARNQCPLFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.29|      18|      28|    1129|    1146|       4
---------------------------------------------------------------------------
 1129- 1146 (36.30/23.38)	CACN....MNIK.GADVGLYIPD
 1155- 1177 (25.99/14.57)	CTCGfsaiVNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.60|      16|      21|    1703|    1722|       5
---------------------------------------------------------------------------
 1703- 1722 (23.32/30.32)	CYTeMLDHL.PEHMrssFILQ
 1726- 1742 (28.29/19.04)	CQY.MLQTMkDEHV...FYIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.84|      23|      28|    2151|    2173|       6
---------------------------------------------------------------------------
 2151- 2173 (40.93/27.80)	PHPLDSKTTSDVLRFVLEQ.YNAL
 2180- 2203 (37.91/25.11)	PATQDRTSCLPVHFVVLTQlYNAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.31|      19|      21|     938|     958|       7
---------------------------------------------------------------------------
  938-  958 (31.76/20.28)	PfvGSSMFAPLKTLPSHC.LLP
  962-  981 (34.55/16.21)	P..DACLFRPSWAVPPKMeQLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.72|      28|      47|     626|     658|       8
---------------------------------------------------------------------------
  602-  643 (38.80/21.56)	P.LMAEASETAL.....ysglrpsytessdRW..WQSfRLPSSEDAEF.RP
  644-  693 (28.92/18.81)	PeLQGERFDTALdlnpestalqrllaqpnkRFkiWQD.EQPQVQPLPFlDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.07|      18|      28|    2016|    2038|       9
---------------------------------------------------------------------------
 2016- 2038 (24.82/26.42)	SPNNDdmfvDLPFPDDmDNDIGI
 2047- 2064 (34.25/17.90)	SPNSS....PVPSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.27|      23|      24|    1375|    1397|      10
---------------------------------------------------------------------------
 1375- 1397 (40.85/23.44)	SPEPLPIPTLLVGY....DKEFLTISP
 1398- 1424 (37.42/20.79)	FSLPFWERLLLEPYgghrDVAYIVVCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.21|      14|     293|     568|     581|      11
---------------------------------------------------------------------------
  568-  581 (28.88/12.24)	PPSVPVNPAL.....YGNG
  863-  881 (23.33/ 8.53)	PPSLEQHPAFspvmnYKDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     290.14|      91|    1264|     163|     266|      13
---------------------------------------------------------------------------
  163-  266 (139.55/111.97)	LSCAFTFFlHGESNVCTSVEIAQHQPIYLINEEHLHMAQSSPAP..FQVLVSPYgLNGTLTGhayKMSDPAAR.KLieewhcfYPMVLRKREEPReEAELGYDDDF..P
 1430- 1525 (150.59/85.48)	LEGAKTFF.RDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQklTEELVSEW.FNQPWSS...EESDNHSRlKL.......YAQVCRHHLAPY.LATLQLDSGLlmP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.95|      25|      25|      60|      84|      14
---------------------------------------------------------------------------
   60-   84 (48.05/30.05)	FIRCLQANLLCVWRRDVKPDCKELW
   86-  110 (47.90/29.93)	FWWGDEPNLVGVIHHELQVVEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.61|      18|      26|     457|     474|      18
---------------------------------------------------------------------------
  457-  474 (29.94/16.58)	PASSKHKTTERQEKGDKL
  486-  503 (30.67/17.16)	PSVAEELCVEQDAPGQKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.05|      16|      16|    1223|    1238|      19
---------------------------------------------------------------------------
 1223- 1238 (27.95/19.45)	SLLLLLQ..NQHTQPFAS
 1240- 1257 (25.10/16.56)	SFLDYISsaNRHALPCVS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31299 with Med13 domain of Kingdom Metazoa
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