<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31297

Description Mediator of RNA polymerase II transcription subunit 13-like
SequenceMSSCFVPNGASLEDCHSNLFCLADLTGIKWKCFVWQGPTSSPILFPVTEEDPILCSFSRCLKADVLSVWRRHQTPGRRELWIFWWGDDPNFAELVHHDLSCNEDGSWESGLTYECRTLLFKAIHNLLERCLMNRSFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFVHGDSNVCTSVEINQHQPVYLLSEEHLTLAQQSSSSVQVILSPYGLSGTLTGQSFKLSDPPTQKLIEEWKQFYPIGPNTKEVTDDKMDDLDWEDDSLAAVEVVVAGVRMVYPASLVLVAQSDIPLVATVSSSSSSGSYAGAPHNQLVHGDTGISSVTLTPPTSPEEAQAVSQPAQKWVKLSAMSGVFSVDSSSHHGGKIPRRLASQMVERVWQECNINRAQNKRKFSTMSNGVCEEETDKASVWDFVESSQRSQCSCSRLKNQKQRACSTPGHPPSAGQPPQPSTKHKMAEKLEKGDKQQKRPLTPFHHRSSLCEEQPSLEQGESVHRLCLQGHEDSRYPSLHHADVTSSKTPMLHSSADEMAGSPQPPPLSPHPCERMEEPADGMKSSSSPLHQHFYPPSSEPCLEPQKPPDESTLDPLPLPCPPPYPETLEATIYVGSAINPNEDTTHNPWKYFRVPGGRNSDFHTPHLPVVAHFEDGNRTGGQDGIVSITEMMSSSKRPLKVSEELVKMYEHKKNQYLSSAVCDEDPEQESDPYAFEEGDEEFNFSDKDKKSGPEREAGKKAKREDGSSSSDDAQGSGGSKPLPTTSLIHETDLVVSINDLDNLFNSDEDDLTQPGSRRAAGGAEEKFGGKEPKPAAPDPLPCCADLHQMFPTPPSLDQGYSPINMGNTESAAGLSLLDGAMSGNFKMEVEEGFCSPKPSEIKDFSYVFKPESCQALIGCSLYAPLKTLPSQCLLPVKLPEECVYRPSWTVGKLGMLQPMAAMTFLNKDSNIPSVGSVVEQEQSCTPQTHNTFMSNSAPPSNSGAGILPSPATPRISAPTPRTPRTPRTPRGPASVQGSLKYENSDLNSPASTPSTCRPLSSVEPATVPSIPEAHSLYVTLILSESVMNLFKDCNFDSCCICVCNMNITGADVGIYISDPNMDSQYSSMDPCSCGFSAVMNRRYGNGAGLFLEDELDIMGRGSDAAREIEKHFEAVRAASLKRGTVLEEQVPDDLMLLLQDLCTNPFSPIIRPDLLGTVIKSPIRLEERDYYSDCYMALEHGRQFMDNMSGGKVDETLVKSSSLHHWAKRNAFDMSMLFSQDVLRMLLSLQPVLQDTIQKKRSVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTLLVGYEYDYVVLSPFALPYWEKLLLDPYSSQRDVGYMVVCPDNEALLNGAKTFFRDLTAVYESCRLGQHRPIAKSHADGIVTVSDAGSKALTDQTLIDWLPKTINSSSSSEALNKLKLYAHVCRHDLASCLASQSLDGSLLTQRNPASSSQTSSSSSPVTTAQNVTPTTNSNSNTNTNTTPTSTSTSSSSSSCPQGVGNMPSSKPNTIPPFGAQGLQSSQQSGGQSAGTLGDATSATSQPQVPSEPAESTMEREKVGVPTDGDSHAVTYPPAIVIYIVNPFSYEENCQGSSSSVWTIALLRCYLEMLQLLPPHIRNAVYVQIIPSQYLLQPVWSEERHIYAQHLKSLAFSVYTQCRRRLPTSTNVKTLTGFGPGLAIDTALQSKERPQCLHLYAPPFVLAPVKDKQTELGETFGEAAQKYNVLFVAYCLSHDQRWLLASCTDQYGELLETCVISIDVPNRARRKKGSARRQGLQKLWEWCLDLVQMTSLPWRIVIGRLGRIGHGELRDWSILLSRRNLQSLGRRLKEMCRMCGISAADSPSILSTCLVAMEPQASFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSAGLQAFSDVTDGMGGMDGILDLFAENDLVDPDLINIIPNSPTTSPVHSPGSHYHHGGDGSKGQGTDRMESHDESPNILQQPMALGYFVSTAKAGPLPDWFWSSCPQAKNQCPLFLKASLHLNVSSVQSDELLHSKHSHPLDSSHTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPVHFVVLNQMYNFIMNML
Length2102
PositionMiddle
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.07
Grand average of hydropathy-0.417
Instability index60.13
Isoelectric point5.49
Molecular weight230989.54
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated gene transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity). 


ECO:0000250	

GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
neural crest cell migration	GO:0001755	IMZFIN
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31297
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.08|      30|      32|    1452|    1482|       1
---------------------------------------------------------------------------
 1452- 1482 (48.32/32.83)	TQRNPASSSQTSSSSSPVTTAQNVtPTTNSN
 1487- 1516 (55.76/33.88)	TNTTPTSTSTSSSSSSCPQGVGNM.PSSKPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.68|      21|      32|     535|     566|       2
---------------------------------------------------------------------------
  536-  560 (32.55/27.91)	PplSPHPCERMEEPADgmKSSSSPL
  567-  587 (39.12/10.36)	P..SSEPCLEPQKPPD..ESTLDPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.69|      24|      33|     428|     451|       3
---------------------------------------------------------------------------
  428-  451 (48.23/23.22)	KNQKQRACS.TPGHPPSAGQPPQPS
  462-  486 (42.46/19.47)	KGDKQQKRPlTPFHHRSSLCEEQPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.28|      31|      33|    1062|    1093|       4
---------------------------------------------------------------------------
 1062- 1093 (56.18/36.54)	KDCNFDSC.CICVCNMNIT.GADVGIYISDpNMD
 1095- 1127 (48.10/26.22)	QYSSMDPCsCGFSAVMNRRyGNGAGLFLED.ELD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.28|      38|     201|    1669|    1706|       5
---------------------------------------------------------------------------
 1669- 1706 (66.71/39.32)	LPTSTNVKTLTGFGPGLAIDTA.LQSKERPQCLHLYAPP
 1869- 1907 (62.56/36.37)	MPDSVSTGSVFGRSTTLNMQTSqLNTPQDTSCTHILVFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     413.01|     143|     548|     663|     830|       7
---------------------------------------------------------------------------
  604-  655 (43.82/10.95)	............................YVGSAINpNEDTTHNPWKYFRVPGGRNSDFHTPHLPVVAHFEDG.....................................NRTGGQDG...............................................................................
  663-  812 (234.43/161.92)	MSSSkrplKVSEELVK..MYEH..KKNQYLSSAVC.DEDPEQESDPYAFEEGDEEFNFSDKDKKSGPEREAG.....................................KKAKREDGSSSSDDAQGSGGSKPLPTTSLI..HETDLVVSinDLDNLF.NS.DEDDLTQPGSRRAAGGAEEKFGGKEpKPAAPDPLP
 1219- 1321 (53.70/17.41)	MSGG....KVDETLVKssSLHHwaKRNAFDMSMLF.SQD.................................vlrmllslqpvlqdtiqkkrsvrswgvqgpltwqqfhKMAGR..GSYGTDES.....PEPLPIPTLLvgYEYDYVV................................................
 1916- 1984 (81.06/30.33)	........................................................................................................................SDVTDGMGGMDGI..LDLF..AENDLVDP..DLINIIpNSpTTSPVHSPGSHYHHGGDGSKGQGTD.RMESHDESP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.39|      32|      38|     978|    1012|       8
---------------------------------------------------------------------------
  956-  975 (22.55/ 6.11)	.............TPQTHNTFMS.NSAPPSNSGA...
  978- 1012 (53.92/39.45)	LPSPA.TPriSAPTPRTPRTPRT.PRGPASVQGSLkY
 1017- 1048 (46.91/24.29)	LNSPAsTP..STCRPLSSVEPATvPSIPEA..HSL.Y
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.48|      27|      42|     821|     847|      10
---------------------------------------------------------------------------
  821-  847 (49.86/34.37)	FPTP.PSLDQGYSPINMGNTESA.AGLSL
  864-  892 (43.62/28.78)	FCSPkPSEIKDFSYVFKPESCQAlIGCSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.19|      14|      29|    1539|    1552|      11
---------------------------------------------------------------------------
 1539- 1552 (23.97/15.87)	TLGDATSATSQPQV
 1570- 1583 (26.22/18.28)	TDGDSHAVTYPPAI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31297 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSVVEQEQSCTPQTHNTFMSNSAPPSNSGAGILPSPATPRISAPTPRTPRTPRTPRGPASVQGSLKYENS
2) INIIPNSPTTSPVHSPGSHYHHGGDGSKGQGTDRMESHDESP
3) LKNQKQRACSTPGHPPSAGQPPQPSTKHKMAEKLEKGDKQQKRPLTPFHHRSSLCEEQPSLEQGESVHRLCLQGHEDSRYPSLHHADVTSSKTPMLHSSADEMAGSPQPPPLSPHPCERMEEPADGMKSSSSPLHQHFYPPSSEPCLEPQKPPDESTLDPLPLPCPP
4) NDLDNLFNSDEDDLTQPGSRRAAGGAEEKFGGKEPKPAAPDPLPCCA
5) SDFHTPHLPVVAHFEDGNRTGGQDGIVSITEMMSSSKRPLKVSEEL
6) SLLTQRNPASSSQTSSSSSPVTTAQNVTPTTNSNSNTNTNTTPTSTSTSSSSSSCPQGVGNMPSSKPNTIPPFGAQGLQSSQQSGGQSAGTLGDATSATSQPQVPSEPAESTMEREKVGVPTDGD
7) YLSSAVCDEDPEQESDPYAFEEGDEEFNFSDKDKKSGPEREAGKKAKREDGSSSSDDAQGSGGSKPLPTTSLIHETD
946
1943
427
769
631
1449
687
1015
1984
593
815
676
1573
763










Molecular Recognition Features






MoRF SequenceStartStop




1) KKAKRE
2) PWKYFRV
3) TKHKMAEKLEK
730
619
452
735
625
462