<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31296

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLVKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPVDDSLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMIIGTNNTSIGTPSPGTPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKISNPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPALSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTGLRSPAGENSDEHYSKDHDMKMEIFSPMPGESCENINPSLSRRLSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKGTTESGVGDEGQKARKTKQEVFPTPENVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILNDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFFPQGTGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVNTMKNEDFGMRGLRRDGNAEDAWATSQNSKSYGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPSSGSVAEMNNLLDNIAKATIEVFQQSADLNNNASNSGMSLFNPNTIGSVDPSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDTKARQMMHEALQLRLNLVGGMFDTVQRSTQGTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSSASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQQHFLLYHTHTMPKPRSYYLEPLPLPPEEEEEELTSPVSQEPERKSAELSDQGKATADEEKKTKGRKRKTKSSSRIDEYQQTNLYRVPPNYSPMSSQMTHHPQPALWGYNLVSQPQQPSFFLQNPSLNPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMLQPPSLHAVTSQQQLLQMKLLQQQQQQQQQQQQQQQRLLRQAQTRPFQQGQPGDQAALFTAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQAAQQQPGGVVLSPSYNSRAYPAAHSSPALMERLRQLQQQPSGYVQQQASPYLQPVAGSQRLNHQALQQSPLVGGGIDAVLTPAHPNLPSVPLPQDPMRPRQQQVRQQQRLLQVWGREMQQPQQAPQPQQPSQTQSQALGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPCAHPSHF
Length2157
PositionKinase
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.07
Grand average of hydropathy-0.435
Instability index58.12
Isoelectric point8.05
Molecular weight241423.22
Publications
PubMed=14621295
PubMed=16141072
PubMed=19468303

Function

Annotated function May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coactivator activity	GO:0003713	IBA:GO_Central
transcription factor binding	GO:0008134	IPI:MGI

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31296
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     124.00|      16|      17|    1885|    1900|       1
---------------------------------------------------------------------------
 1885- 1900 (31.21/12.87)	QM..KLLQQQQQQQQQQQ
 1954- 1969 (24.21/ 8.21)	TM..YGTQMPLQQAAQQQ
 2060- 2075 (21.53/ 6.42)	PM..RPRQQQVRQQQRLL
 2076- 2093 (22.31/ 6.94)	QVwgREMQQPQQAPQPQQ
 2110- 2125 (24.74/ 8.56)	QQ..PLFPRQGLQQTQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.31|      47|     150|    1079|    1154|       2
---------------------------------------------------------------------------
  873-  907 (36.42/11.27)	.......................GSYTTglCVCIVAVLRRYHSCLIlnPDQTAQVFEG
  910-  939 (47.25/19.28)	GVVKHVVNPS....ECSSPE.....R....C.ILAYLYDLYVSC..............
 1101- 1154 (78.63/108.56)	DVVQHVALPSllaaACGDADaepGARMT..CRLLLHLFRAPQACFF..PQGTGKPFPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     396.73|      58|     155|    1817|    1874|       3
---------------------------------------------------------------------------
 1576- 1616 (34.65/13.78)	.............................L..................INGTLAS..DLSSASPGG....S...EENKRAY..MNLVKKLKKELGDK..RS.
 1629- 1679 (53.30/25.74)	......PKQ................TCDVI.....................TCEP..MGSLIDTKGnkiaGFDSIDKKQAR..G..LQVSTKQKVSP..WDL
 1715- 1765 (54.27/26.37)	YHTHTMPKP................RSYYL..................EPLPLPPeeEEEELTSPV....SQEPERKSAEL..SD..QGKATA.........
 1817- 1874 (101.93/56.93)	YNLVSQPQQ................PSFFL..................QNPSLNP..GGSRLDPAG....SFVPTNTKQAL..SNMLQRRSGAMLQP..PSL
 1875- 1943 (59.29/29.58)	HAVTSQ.QQ...................LLqmkllqqqqqqqqqqqqqQQRLLRQ..AQTR..PFQ....QGQPGD.QAAL..FTAQARPSPQLPQY..PGL
 1953- 2006 (46.69/21.51)	Y........tmygtqmplqqaaqqqPGGVV..................LSPSYN.....SRAYPAA....HSSP.....AL..ME....RLRQLQQQ..PSG
 2007- 2051 (46.59/21.44)	Y..V.Q.QQ................AS.......................PYLQPvaGSQRLN............H..QALqqSPLVGGGIDAVLTPahPNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.67|      24|      27|    1472|    1495|       8
---------------------------------------------------------------------------
 1472- 1495 (40.18/26.11)	VLTCLKG...QDE..QREGLLTSLQNQVN
 1497- 1525 (32.49/19.49)	ILSNWREeryQDDtkARQMMHEALQLRLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.57|      24|      27|     997|    1021|       9
---------------------------------------------------------------------------
  997- 1021 (40.99/30.80)	GKIlND..NAANRYSFVCNTLMNVCMG
 1026- 1051 (39.58/24.80)	GRI.NDiaNFSSELTACCTVLSSEWLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.02|      11|     195|    1052|    1072|      10
---------------------------------------------------------------------------
  373-  383 (25.26/ 6.14)	LCCPSALVWNY
 1056- 1066 (25.76/17.69)	LCCSSNHVWGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.16|      30|     254|     554|     584|      18
---------------------------------------------------------------------------
  554-  584 (46.82/35.21)	ESISS.ASLAGSSLPVFQNVLLRFlDTQAPAL
  811-  841 (50.34/33.23)	EQITSfASGTSYHLPLAHHIQLIF.DLMEPAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31296 with Med12 domain of Kingdom Metazoa
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