<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31292

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSGSNAKSSGTGFGSHIPSIEEKNKQIQQETMMEKLRAKYRNKPKSYEEIKKSVRMYFIEKHYPLDPLCKATLQSALDKLQHYIKVTSRHGLVERLESLSRQLGLKFMEDQQLLFISTDMFYVEILLDAAGSLSDVKVHHECKIEQQSSELVACLKSGDFADFTVQLEGLSSIYQLNAEPKVKKKAFVALQAMETDIQSLYQLHLQGHSGDSYSLMTSSSVGLVLPRRGGHPMRLTYFCPPLHLPEGDPKLASGDFTIDQVMRSSYGLSATINLEGSSANKLQTLPTVTLVRDAQTGLEVPTYAQLNQNNSLLMPATFVLRLNKPMPVCLESLKALGLPGLDSVATPPGPPTTVLNLIVQTASKQAIKNTQRGLYVNLPKETHCYFFTDNRKLQGTLVSSLPFTEPAQVPRIVAFLKKQALFYTLLASCVREQQKQYNDMDSTVILEVTAVSFNQITVELQHPYEESLATVDFLLEDGQPTCSVYCLTNEYELLSQKLTRTARKVVSIPMVIYKLLKCWDEEHEFKLHGAIGPGSGSGAIGGGGMSGGGPVSGVGNNFSQFSMDTPTPSDGSLPGGGFANINNLKMDAKSRSLADAFAASTSAAAAIAGLINLKRETDPQSGSSASGTTVSGSSSSSGSAKTSDHDIADKYKNIWKDKTPNLKHCVSITPIPGDGKSGSAGGVSGVEVQRTGGIEIIPLNAQAAIAGGGVTASSSATPTTITITPITGKDPSKDSTKKSTAASAGVGVAAKRPHESSTSSSSTSGCSGSGSSMSSSASSGSSDTQKEKKRKKKRDDSPMGPPEKIYSRQNSPAGGADASATGGVVRKFSSPSSSPKAGGGGQGLMAGVPTARPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHGSSGKPSMSTLKSAATAATILSPKGDKSSSAVGNTSSGPSASSGSSGATGLVRSFASVGAPPPPPPIPPLASSSGSISSSQSLKKEKTSSASGSSSTSSSATAGVASGGGISPASVAAAVAALKSSQQQMKSVASLSHLAAGGGLGSYAAPSGAGASGAAAVVVGAGAGAGAGASGLELSALRKGMAGGAFDDVDGSFSANNSGTNNNSGSGLGSVIGVSSLSGSGSGAGNSGSSGSSNAGNSNNSAAAATAGSSAN
Length1141
PositionMiddle
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.05
Grand average of hydropathy-0.277
Instability index49.02
Isoelectric point9.17
Molecular weight116800.51
Publications
PubMed=10731132
PubMed=12537568
PubMed=12537572
PubMed=12537573
PubMed=12537574
PubMed=16110336
PubMed=17569856
PubMed=17569867

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31292
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     761.89|     135|     140|     519|     657|       1
---------------------------------------------------------------------------
  522-  634 (184.63/64.41)	........................EHEFKLH.G.AIGPGSGSGA.IGGGGMS...............G..GGPVS...GV......GN.NFSQFSMDTPTPSDGSLPGGG....F........ANINNLKMDAKSRSLADAFAASTSAAAAI............AGLINLKRETDPQ.SGSSASGTTVSGSS
  635-  772 (157.64/53.90)	SSSGSAKTSDHDIADKYKNiWKDkTPNLKHC.V.SITP.......IPGDGKS...............GsaGG.VS...GVevqrtgGI.EI......IPLNAQAAIAGGG....VtasssatpTTITITPITGKDPS.KDSTKKSTAASAGV.............G.VAAKRPHESStSSSSTSGCSGSGSS
  774-  880 (144.38/46.64)	SSSASSGSSDTQKEKKRKK.KRD........dS.PMGP.PEKIY.SRQNSPA...............G..GADAS...AT......GG.VVRKFSSPSSSPKAG...GGG.qglM........AGVPTARPSPKHSPV...YSSP.........................KHNTASN.SPKSPFGTH.....
  881-  979 (97.05/28.24)	....................................SPKHGSS...GKPSMStlksaataatilspkG..DKSSS...AV......GN.TSS.....GPSASSGSSGATGlvrsF........ASVGAPPPPPPIPPLA.......SSSGSI............SSSQSLKKE.....KTSSA.....SGSS
  980- 1084 (101.00/30.33)	STSSSATAG...................................vASGGGIS....................PASvaaAV......AAlKSSQQQMKSVASLSHLAAGGG....L........G............SYAAPSGAGASGAAAVvvgagagagagaSGL.ELSALRKGM.AGGAFDDVDGSFSA
 1085- 1140 (77.19/21.38)	NNSGTNNNSGSGLG...................sVIGVSS..........LS...............G..SG..S...GA......GN.S..........GSSGSSNAG...............NSNN..................SAAAAT............AG..............SSA.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     258.67|      84|      95|     155|     247|       2
---------------------------------------------------------------------------
  155-  247 (124.78/111.43)	LKSGdfaDFTVQlEGLSSIYQLNAEPKVKKKAFVALQAMET.....DIQSLYQLHLQGHSGDSYSLMTSSSvgLVLprRGGHPMRLTYFC.PPLHLPeG
  251-  340 (133.88/88.47)	LASG...DFTID.QVMRSSYGLSATINLEGSSANKLQTLPTvtlvrDAQTGLEVPTYAQLNQNNSLLMPAT..FVL..RLNKPMPVCLESlKALGLP.G
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31292 with Med1 domain of Kingdom Metazoa
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