<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31290

Description "Crooked legs, isoform H"
SequenceMQHVSAASSVPSVVTPVVTTGGTTITLGGPPPLPKSEHKEDGKPPHGIEMYKVNIEDISQLFTYHEVFGKIHGDVVNHQLAAAHGGQLPPPPPLPPQVTSHAASAAAAAAAASTNNAAVAAVMASANAAAAAAAAASAGGGLPPATSGNGGQQVTVTTTSSSTSSGGSTTSGGTTTTAGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTAGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKVPHHSATTTMHTIQQITAGAAGGAGAVQLTPGLVPLVTSTLISHNAAAQQQSQKQQAAAAAAAQQQAAAAAAAQQQAAQQQAAAAHQQHQQQVAAQHQQQAAVAAHQQQQQQLQQQQQLLQLSIQQAAHHHQQEQHRQQQQQQHQQQQQQQHHQQQQQGHPQAPPPQQQQQPPPIALISDPSALARAAIQLQHLPANVEQHPVVY
Length686
PositionKinase
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.04
Grand average of hydropathy-0.782
Instability index52.06
Isoelectric point9.26
Molecular weight75058.98
Publications
PubMed=10731132
PubMed=12537568
PubMed=12537572
PubMed=12537573
PubMed=12537574
PubMed=16110336
PubMed=17569856
PubMed=17569867

Function

Annotated function 
GO - Cellular Component
heterochromatin	GO:0000792	IDA:FlyBase
nucleus	GO:0005634	IDA:FlyBase

GO - Biological Function
DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	IBA:GO_Central
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IBA:GO_Central

GO - Biological Process
cell adhesion	GO:0007155	IMFlyBase
heterochromatin organization involved in chromatin silencing	GO:0070868	IMFlyBase
imaginal disc-derived wing morphogenesis	GO:0007476	IMFlyBase
negative regulation of transcription, DNA-templated	GO:0045892	IMFlyBase
negative regulation of Wnt signaling pathway	GO:0030178	IGI:FlyBase
positive regulation of mitotic cell cycle	GO:0045931	IMFlyBase
regulation of chromatin silencing	GO:0031935	IMFlyBase
regulation of transcription by RNA polymerase II	GO:0006357	IMFlyBase









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31290
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|     547.31|      24|      26|     258|     281|       1
---------------------------------------------------------------------------
  179-  196 (30.57/11.07)	........G...QTPHQCDVCGKKYTRKE
  201-  224 (51.59/23.07)	HM.RSHT.N...ETPFRCEICGKSFSRKE
  229-  253 (49.88/22.10)	HI.LWHTaG...ETPHRCDFCSKTFTRKE
  258-  281 (59.02/27.32)	HV.RQHT.G...ESPHRCSYCMKTFTRKE
  286-  309 (54.17/24.55)	HI.RQHT.G...ETPFKCTYCTKAFTRKD
  314-  337 (58.69/27.13)	HV.RQHT.G...ESPHKCTYCTKTFTRKE
  342-  365 (58.28/26.90)	HV.RQHT.G...DSPHRCSYCKKTFTRKE
  370-  393 (56.62/25.95)	HV.RLHT.G...DSPHKCEYCQKTFTRKE
  398-  421 (51.11/22.80)	HM.RQHS.S...DNPHCCNVCNKPFTRKE
  426-  450 (45.18/19.42)	HMsRCHT.G...DRPFTCETCGKSFPLKG
  455-  481 (32.20/12.00)	HQ.RSHTkGqemERPFACEKCPKNFICK.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     139.98|      21|      22|     553|     573|       2
---------------------------------------------------------------------------
  546-  570 (36.86/10.72)	QQAaaaaAAQQQAAQ...QQAAAAHQ..QH
  571-  590 (34.05/ 9.37)	QQQ...vAAQHQ..Q...QAAVAAHQ..QQ
  591-  617 (29.63/ 7.25)	QQQ...lQQQQQLLQlsiQQAAHHHQqeQH
  621-  637 (39.43/11.95)	QQQ....QHQQQ.QQ...QQ...HHQ..QQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.83|      16|      22|      98|     113|       3
---------------------------------------------------------------------------
   98-  113 (27.59/10.10)	VTSHAASAAAAAAAAS
  122-  137 (26.24/ 9.31)	VMASANAAAAAAAAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.07|      13|      25|     139|     155|       5
---------------------------------------------------------------------------
  139-  155 (15.07/17.76)	GGGlppATSGnGGQQVT
  165-  177 (25.00/11.22)	SGG...STTS.GGTTTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.65|      11|      27|     643|     653|       6
---------------------------------------------------------------------------
  643-  653 (22.39/ 9.45)	QAPPPQQQQQP
  673-  683 (21.25/ 8.58)	QHLPANVEQHP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31290 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAASAGGGLPPATSGNGGQQVTVTTTSSSTSSGGSTTSGGTTTTAGQ
2) HNAAAQQQSQKQQAAAAAAAQQQAAAAAAAQQQAAQQQAAAAHQQHQQQVAAQHQQQAAVAAHQQQQ
3) HQLAAAHGGQLPPPPPLPPQVTSHAASAAAAAA
4) LLQLSIQQAAHHHQQEQHRQQQQQQHQQQQQQQHHQQQQQGHPQAPPPQQQQQPPPIALISDPSALARAAIQLQHLPANVEQHPVVY
5) VTTGGTTITLGGPPPLPKSEHKEDGKPPHGIEM
133
525
78
600
18
180
591
110
686
50










Molecular Recognition Features






MoRF SequenceStartStop




NANANA