<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31289

Description "Checkpoint suppressor 1-like, isoform C"
SequenceMSTDNPTQLLTTRDLSQLRGHLQSGTVAVPSTTTSVVAAAAATVAAAHGYRTIAPPQQPANNSSTTTSATAASASASAQPPVIPPVISTSNSNMPASASKYVFLQHNHNGGFTAYDGSAATTAAGSTGTVGATSGNIVLLAAAPLEASSGEALVNVRTTEDDGELRSLSWLSDTNLIKGIVTTTAGQAGKRAATVAIKSATGAAGTVGSGAPNGNLCIVSDLIEELPTNLSETSEQESTGGAASGSAPAASTVYSTTTVHKGASGTTTVVEYKASKANQQQQNSPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTYLPTPTRTTMVGHGYMPVVVSSASQPILSPAKQQLPQQIYVTSNGSSPAGGGTIYKAASQALSSPTTSSSSSSNTTTHHPHKKYLREKMHVQMDHSSHVASTVTVVSSPASSNNSSISSSNTGSVSGSGSSTAAVNGGNSPVPKTSSFSTVFEAVNYATSAASNSSSSSNSTPNSQAILHGQESPAVVTTTTLISAGTLPPGYSFVNQVASTPHVLSTPAHVASPETPPGAALLPGTYYATSTTSAGTTTTTLQARSLQLSVSPPPPNMTPTSQVHNGSLGGGGGGGGGSGGGGGGGGANLRSPNSYASYDNEDSLKEFDLVVSSRLHTSTPQYSVSKNGANGYGNGNSNVNGSGAGSNTPQKQKHPNNVPYDPLVHTNNKPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKVEKAPNMGKGSLWRVEPQQRQNLIQALNRSPFFPNSAVDKISPSLKSPSGGSAYDSLDGGGSGSVSSAQPVAGGAGVPAAAAVALSTPTKSNGLALANGASQATNAARPHSPNGGGSGSHARFDPYLFPNLSKAFRNIREDTVGQPMLQDALDDELSGDYHNNNNNNSGSKYNYMGANGSGGAGSGGVGSNANGASDGINFARLARDCGADSIDDVHAAAAMLYLKHGPKIYSEPFQNGGPVITSSPSEDHTYSAGGNSNADSGSSTPLTNGNALASVAQAVAQGQNNQGGAGSDSNCASSDAAYDSSEENHNITPEEMADRQRHRDGVDALLSLSGSSIVECGSVATTHYHSNGSSGSSHGSPHKRASSHSLEEEHLQQHREQQLQQQQQQQQHHHQQFGSSQAVYTNGSGSKMALLSSAAANVALAQQQQQQIHQDMYSSTAGHNASMYLGGLNSHCLSGGGGVGVAAGMLPQHLSAATGASNKNKVKPLRGLRTKFKRKSAWMR
Length1267
PositionKinase
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.05
Grand average of hydropathy-0.535
Instability index55.52
Isoelectric point8.08
Molecular weight129879.72
Publications
PubMed=10731132
PubMed=12537568
PubMed=12537572
PubMed=12537573
PubMed=12537574
PubMed=16110336
PubMed=17569856
PubMed=17569867

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	IBA:GO_Central
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IBA:GO_Central
transcription regulatory region sequence-specific DNA binding	GO:0000976	IDA:FlyBase

GO - Biological Process
cellular response to hypoxia	GO:0071456	IMFlyBase
embryonic heart tube development	GO:0035050	IMFlyBase
mitotic G1 DNA damage checkpoint	GO:0031571	IGI:FlyBase
regulation of cell division	GO:0051302	IMFlyBase
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31289
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.91|      15|      15|     286|     300|       1
---------------------------------------------------------------------------
  278-  295 (28.80/11.24)	NQQQQnspQQQQQQQQQQ
  296-  311 (30.53/12.24)	QQQQQ..qQQQQQQQQQQ
 1143- 1157 (32.59/13.42)	EQQLQ...QQQQQQQHHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     559.30|      91|      94|     791|     881|       2
---------------------------------------------------------------------------
  427-  496 (67.58/17.25)	......................SPA.....SS.....NN..........SSI..SSSNTGSVSGSGSSTAAVNGGnSPV....PKTS....................SFSTV...F................EA...VNYATSAASNSSsssnstP.N.......SQA
  583-  679 (100.52/29.16)	PP.PPN.....M..........TPTSQ...VH.....NG.................SLGGGGGGGGGSGGG.GGG.GGAnlrsPNSYAsydnedslkefdlvvssrLHTSTP...QYS..........VS.KNG...ANGYGNG...NS......NvNGSGA..GSNT
  690-  773 (72.31/18.96)	PY.DP.....LV..........HTNNK...PP.....YS..........FSSliFMAIE....GSNEKALPVK..........EIYAW..................IVQHFPyfkTAPNGwknsvrhnLSLNKSfvkVEKA..............P.N.MGK..GSLW
  791-  881 (163.49/51.93)	PF.FPNSAVDKI..........SPSLK...SP.....SG..........GSA..YDSLDGGGSGSVSSAQPVAGG.AGV....PAAAA..................VALSTP...TKSNG........LALANG...ASQATNAARPHS......P.NGGGS..GSHA
  885-  978 (69.83/18.06)	PYlFPN..LSKAfrniredtvgQPMLQ...DAlddelSGdyhnnnnnnsGSK..YNYMGANGSGGAGS.....GG.VGS..............................N.....................ANG...ASDGINFARLAR......D.CGADSidDVHA
  995- 1058 (85.57/23.76)	PF.QNGGPVITS..........SPSEDhtySA.....GG..........NSN..ADS...G......S.........................................STP...L.TNG........NALAS....VAQAV.AQGQNN......Q.GGAGS..DSNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.52|      13|      58|     121|     133|       3
---------------------------------------------------------------------------
  121-  133 (22.12/11.75)	TTAAGSTGTVGAT
  182-  194 (20.40/10.13)	TTTAGQAGKRAAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.31|      26|      58|    1060|    1086|       4
---------------------------------------------------------------------------
 1060- 1079 (25.75/10.25)	............SSDAAYDSSEENHNITPEEM
 1080- 1106 (31.75/16.85)	ADRQRH....rdGVDALLSLS.GSSIVECGSV
 1107- 1138 (35.82/17.95)	ATTHYHsngssgSSHGSPHKRASSHSLEEEHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.86|      22|      58|     497|     518|       5
---------------------------------------------------------------------------
  497-  518 (35.53/15.38)	IL.......HG.....QESPAVVTTTTLISAGTL
  524-  552 (27.97/10.59)	FVnqvastpHV.....LSTPAHVASPETPPGAAL
  553-  577 (25.35/ 8.93)	L........PGtyyatSTTSAGTTTTTL.QARSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.51|      22|      23|      54|      75|       6
---------------------------------------------------------------------------
   54-   75 (39.09/20.74)	APPQQPANNS..STTTSATAASAS
   76-   99 (33.41/16.37)	ASAQPPVIPPviSTSNSNMPASAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.92|      23|      24|     343|     365|       7
---------------------------------------------------------------------------
  343-  365 (37.05/18.88)	SQPILSPAKQQLPQQIYVTSNGS
  370-  392 (32.91/15.91)	GGTIYKAASQALSSPTTSSSSSS
  393-  415 (38.97/20.26)	NTTTHHPHKKYLREKMHVQMDHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.31|      12|      15|    1213|    1225|       8
---------------------------------------------------------------------------
 1213- 1225 (19.13/12.61)	GGLNSHcLSGGGG
 1231- 1242 (23.18/10.01)	GMLPQH.LSAATG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.35|      18|     874|     312|     335|      10
---------------------------------------------------------------------------
  312-  335 (32.16/23.40)	QQQQQ...QTTYLPTPtrttmvGHG...YM
 1189- 1212 (26.19/ 9.51)	QQQQQqihQDMYSSTA......GHNasmYL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31289 with Med12 domain of Kingdom Metazoa
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