<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31288

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFYALTDLCGIKWRKFVNGERPNASSDPLADPILRSYSRCIQADMLCVWRRVQSTKTDHADPNALTFEMTTSTKVHPPLSLAAAKELWIFWYGEEPDLSELVDAELLRVAANQALWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLTEAAAAFAAASSPPGSNGSAASAGGAVPNPGQDPNGASMDGLDGGEGAAKAAPPPHARKVMLAPFGIAGILTGNSYKASDPIAEKILEDWASFFPLCNKDNTDVPPVVEVVSGGHKMYHPTNYVLVTDLDDMEHMEFVEMQKMQSSVAGAAAESAVLASLSCPPGAASAPSSMGAAPSATAVPLGPASLNAPALAGAGVGATASSAAKEISRKAAPQAVSALERLAFQPYYDQRPTSGFTFNTNNTHIPASAAVEMPERTWQDCVMNTLHVDAAAAAAAVASSTPASGTGSLSADGDENEQNKPPQDSKQLVQQQIQQQQQRQKLWNFVDPMQKAPCICTKHLGNTPHGTPHGGASTYSRNSLGGDSSMPVASVESPATPAPSPHPNSAHSQPTSVPPAEQPPTPIDHLLDKNTPAPTPTDQHDSKSITASPYVHQTPSVEPPSYTDHAAGGGPAGGQGLGTGPGSVPAQQPATPTAATSAGGAGSGGPSNAIGANAVGTISVKKLEMQQQTPSAAMAIKQEPGAQGRGVGGVTSTTEALNNFKRLYNPPKLTLKDPDSFYDEEWLKEVIYDFQYQEYWDYSTVKRPKMEKQRRPRYAKNLYEGQNHVKPVMPSPGSVYGSQLLSLDESASQAGGRGGGGQAAGSSGGGLVGIANSTASGSDVEADGSSFFQGLNIKTEPGLHSPSCKETSKSSGGNSSGGGSGSGGNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSAVTNTIEDLKRSTAVASAAVAAAAAAAASGAGNIQAEDLTKMFPTPPSHEQQHPNSSPCQTDVVMTDLSVDTTTTIITSSITTTCNTTITSSINTTTTACSNPSNSIMLAAAQAPVTVVAIQTVSKMVKQEYNLELGSPMEEPINDWDYVYRPPQQEKFVGSTRYAPLTNLPSQTQPPLTLPTGCFYQPTWSSHKSRAATLAKAAAAQQQQHQKHQALQQRIQLHQQKLQQLQLQNQQQQQAAAAAAAAASGGVGHQKHQHQHLHDLLSAAPRTPLTPSTVPQPLSSGGSQYLLNQLNCPQAPPGASMQQLMHRAGMSPISPGPGMGPYAARSSPMSRATPTHPPPPYPYDLAVASPATSTSSYLNRPLHSQEHPHMHGLGGGATGVVGHGTGGGGHMGMVAYTGDAGIVSGGTAMAAGSSSLLQELPEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGVYVPLPGVSFNPFPSGAGGALAGQRMLNGPSSAGFGGMRMISAFGGSPASASMPGAGSGHGHGPNGGSNSSSCTPPSSNPHITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDEVEITGIADDPGRNKQPTLLSIIQSLSRKNQNKQGPGETSSALDKIGAGGLPNGQLEQLGHAVFDLLLDQCSIIQTSSSSVHRALQSHRRRMSRQRRIFGNNGAPTASLASIANVLEFMDAHDVISLALEQSRLAFENQRMDNMMDFHGNGSSSSHQQQQLTAFHAPPPALRHKLAGIGAGRLTVHKWPYLPVGFTRSNKEIVRTMNAIQPMLQNAFHCKSRGGSGSKDASSYNTVSGPLTWRQFHRLAGRASGQCEPQPIPSVVVGYEKDWISVAPHSIHYWDKFLLEPYSYARDVVYVVVCPDNEHVVNCTRSYFRELSSTYEMCKLGKHTPIRGWDGFLQVGAARNNVPADRETTPLDDWLRTLEHAALAEQIRRYAVAFIHQLAPYLSRVPNDKTLLNPPDGSGNSHSKGGSSCSSNSSSVSGLPGGDLPTDNIKLEPGTEPQVQPMETNEIKQEPGVGKGGTAAGETKPTLILGDPLGMGETLEDINPSAIVLYVVNPFTFASDSCELERLALIALLRCYAELLKAVPDSVRSQMNIQIISLESVMELGPCGNRKRFSDEIRCLALNIFSQCRRHLVHAQSVKSLTGFGTAANMEAFLKTKDEPNRRAYKMYTAPFVLAPMHERNDKTDFSRSAGSMHGQNEHRYSVMYCNYCLSEDQAWLLATATDERGEMLEKICINIDVPNRARRRKAPARYVALKKLMDFIMGIISQTSQMWRLVIGRIGRIGHSELKSWSFLLSKQQLQKASKQFKDMCKQCTLMYPPTILSACLVTLEPDAKLRVMPDQFTPDERFSQISMQNPLATPQDVTCTHILVFPTSAVCAPFTRQFQNEPQVDDDFLTFEEEGNEDFSDADIGDLFWDTHMDRVSNHGSPGRMDDNRSWQSAGGNNFKCTPPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPSIQSADDILNSTNAHQSGNDHPLDSNLTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2601
PositionMiddle
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.380
Instability index49.98
Isoelectric point6.08
Molecular weight278201.45
Publications
PubMed=10731132
PubMed=12537568
PubMed=12537572
PubMed=12537573
PubMed=12537574
PubMed=16110336
PubMed=17569856
PubMed=17569867

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31288
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     113.48|      17|      20|    1298|    1314|       1
---------------------------------------------------------------------------
  602-  617 (28.51/ 8.31)	PATPAPSPHPN.SA.HSQ
 1254- 1270 (25.91/ 6.86)	PLTPSTVPQPL.SSGGSQ
 1298- 1314 (30.85/ 9.61)	PISPGPGMGPY.AARSSP
 1320- 1336 (28.21/ 8.14)	PTHPPPPY.PYdLAVASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.19|      29|     220|     998|    1026|       2
---------------------------------------------------------------------------
  400-  429 (36.88/15.70)	AAPSATAVPL.GPASL...NAPALagAGVGATAS
  998- 1026 (47.03/22.45)	AVAAAAAAAASGAGNI...QAEDL..TKMFPTPP
 1221- 1251 (42.27/19.28)	AAAAAAAAASGGVGH.qkhQHQHL..HDLLSAAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.02|      18|      20|    1485|    1502|       3
---------------------------------------------------------------------------
 1354- 1375 (29.42/ 9.36)	PHMH...GLGGGatgvVGHGTGGGG
 1485- 1502 (30.70/10.08)	PSSA...GFGGM....RMISAFGGS
 1503- 1523 (30.90/10.19)	PASAsmpGAGSG....HGHGPNGGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     446.14|      85|     457|     176|     266|       4
---------------------------------------------------------------------------
  176-  260 (146.11/72.94)	QPCTSSDRL.F.GRSS.......QHLSFSFTF..FVHGDTVCASIDLREHPA.VRP.....LTKEHLTEAAAA.....FAAASSPPGSNGSAASAGG...AVPNPGQDPN
  337-  399 (69.66/30.25)	..............SG.......GHKMYHPTN..YV....LVTDLDDMEHME.FVE.....MQKMQSSVAGAAaesavLASLSCPPGA.ASAPSSMG.............
  442-  534 (106.72/49.73)	QAVSALERLaFqPYYD.......QRPTSGFTF..NTNNTHIPASAAV.EMPE..RTwqdcvMNTLHVDAAAAA.....AAVASSTPASGTGSLSADGdenEQNKPPQDSK
  626-  718 (116.12/55.27)	QPPTPIDHL.L.DKNTpaptptdQHDSKSITAspYVHQTPSVEPPSYTDHAAgGGP.....AGGQGLGTGPGS.....VPA..QQPATPTAATSAGG...AGSGGPSNAI
  910-  931 ( 7.53/ 8.16)	.....................................................................................PSCKETSKSSGG...NSSGGGSGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     196.77|      64|     457|    1524|    1590|       5
---------------------------------------------------------------------------
 1524- 1563 (52.56/26.68)	................................N....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSSCTPPSSNPHITGYVDDDPVEcTCGFSAVVNRRLSHR
 1564- 1588 (23.39/ 7.56)	AGLFYEDEVEITGIADDPGRNKQPT...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 2393- 2427 (43.96/17.39)	.................................llsiiqslsrknqnkqgpgetssaldkigagglpngqleqlghavfdllldqcsiiqtssssvhralqshrrrmsrqrrifgnngaptaslasianvlefmdahdvislaleqsrlafenqrmdnmmdfhgngsssshqqqqltafhapppalrhklagigagrltvhkwpylpvgftrsnkeivrtmnaiqpmlqnafhcksrggsgskdassyntvsgpltwrqfhrlagrasgqcepqpipsvvvgyekdwisvaphsihywdkfllepysyardvvyvvvcpdnehvvnctrsyfrelsstyemcklgkhtpirgwdgflqvgaarnnvpadrettplddwlrtlehaalaeqirryavafihqlapylsrvpndktllnppdgsgnshskggsscssnsssvsglpggdlptdniklepgtepqvqpmetneikqepgvgkggtaagetkptlilgdplgmgetledinpsaivlyvvnpftfasdscelerlaliallrcyaellkavpdsvrsqmniqiislesvmelgpcgnrkrfsdeirclalnifsqcrrhlvhaqsvksltgfgtaanmeaflktkdepnrraykmytapfvlapmherndktdfsrsagsmhgqnehrysvmycnyclsedqawllatatdergemlekicinidvpnrarrrkaparyvalkklmdfimgiisqtsqmwrlvigrigrighselkswsfllskqqlqkaskqfkdmckqctlmypptilsaclvtlepdaklrvmpdqftpderfsqismqnplatpqdvtcthilvfptSAVCAPFTRQFQNEPQVDDDFLT....FEEEGNEDFSDA
 2430- 2487 (76.86/36.73)	GDLFWDTHMDRVSNHGSPGRMDDNRswqsaggN....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NFKCTPPQEVEEV.GSLNQQPI..SVGY...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.69|      29|     457|    1151|    1210|       8
---------------------------------------------------------------------------
  556-  585 (52.03/16.63)	PMQKAPCIcTKHLG..NTPHGTPHGG.ASTYSR
 1151- 1182 (44.66/60.14)	PSQTQPPL.TLPTGcfYQPTWSSHKSrAATLAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     253.05|      78|     870|    1622|    1700|       9
---------------------------------------------------------------------------
 1622- 1700 (126.83/84.76)	PNGQLEQLGHAVFDLLLDQCSIIQTSSSSVH.RALQSHRRRMSRQRRIFGNNGAPTASlASIANVLEF.MDAHDVIS.LALE
 2493- 2573 (126.22/80.16)	PTGRMPAWFWSACPHLEDVCPVFLKTALHLHvPSIQSADDILNSTNAHQSGNDHPLDS.NLTADVLRFvLEGYNALSwLALD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.87|      22|     457|    1274|    1295|      10
---------------------------------------------------------------------------
 1274- 1295 (42.70/23.80)	NQLNCPQAPPGASMQQLMH.RAG
 1729- 1751 (38.17/20.30)	QQLTAFHAPPPALRHKLAGiGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.86|      14|      23|    1038|    1054|      12
---------------------------------------------------------------------------
 1038- 1054 (21.03/22.83)	CQTDVVMtdlSVDTTTT
 1064- 1077 (25.83/17.28)	CNTTITS...SINTTTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.21|      14|     669|     535|     548|      13
---------------------------------------------------------------------------
  535-  548 (27.51/18.81)	QLVQQQIQQQQQRQ
 1195- 1207 (18.27/ 9.67)	QALQQRIQLHQQK.
 1210- 1220 (15.42/ 6.85)	...QLQLQNQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.50|      16|      23|     855|     875|      14
---------------------------------------------------------------------------
  855-  871 (25.40/ 8.99)	ASQAGGrGGGGQAAGSS
  879-  894 (24.10/ 9.67)	ANSTAS.GSDVEADGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.48|      20|      23|     266|     285|      15
---------------------------------------------------------------------------
  266-  285 (36.35/21.17)	GLDG.GEGAAKAAPPPHARKV
  291-  311 (30.12/15.96)	GIAGiLTGNSYKASDPIAEKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.40|      36|    1280|     744|     782|      16
---------------------------------------------------------------------------
  744-  782 (61.14/44.08)	IKQEPGAQGRG..VGGVTSTTEALNNFKRlynPPKLTLKDP
  964-  990 (39.02/18.81)	IHTPPDSNNPS..NGGCSAVTNTIEDLKR............
 2026- 2051 (40.25/20.59)	IKQEPGV.GKGgtAAGET..............KPTLILGDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31288 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAVASSTPASGTGSLSADGDENEQNKPPQDSKQLVQQQIQQQQQRQKLWNFV
2) ASASMPGAGSGHGHGPNGGSNSSSCTPPSSNPHITGY
3) EADGSSFFQGLNIKTEPGLHSPSCKETSKSSGGNSSGGGSGSGGNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSAVTN
4) IQAEDLTKMFPTPPSHEQQHPNSSPCQTDVVM
5) MEKQRRPRYAKNLYEGQNHVKPVMPSPGSVYGSQLLSLDESASQAGGRGGGGQAAGSSGGGLVGIANSTAS
6) NGSAASAGGAVPNPGQDPNGASMDGLDGGEGAAKAAPPP
7) PCICTKHLGNTPHGTPHGGASTYSRNSLGGDSSMPVASVESPATPAPSPHPNSAHSQPTSVPPAEQPPTPIDHLLDKNTPAPTPTDQHDSKSITASPYVHQTPSVEPPSYTDHAAGGGPAGGQGLGTGPGSVPAQQPATPTAATSAGGAGSGGPSNAIGANAVGTISVKKLEMQQQTPSAAMAIKQEPGAQGRGVGGVTSTTEALNN
8) RAATLAKAAAAQQQQHQKHQALQQRIQLHQQKLQQLQLQNQQQQQAAAAAAAAASGGVGHQKHQHQHLHDLLSAAPRTPLTPSTVPQPLSSGGSQYLLNQLNCPQAPPGASMQQLMHRAGMSPISPGPGMGPYAARSSPMSRATPTHPPPPYPYDLAVA
9) RNKQPTLLSIIQSLSRKNQNKQGPGETSSALDKIGAGG
10) RVSNHGSPGRMDDNRSWQSAGGNNFKCTPPQEVE
11) VPNDKTLLNPPDGSGNSHSKGGSSCSSNSSSVSGLPGGDLPTDNIKLEPGTEPQVQPMETNEIKQEPGVGKGGTAAG
501
1504
889
1013
814
242
561
1176
1583
2440
1964
554
1540
983
1044
884
280
767
1334
1620
2473
2040










Molecular Recognition Features






MoRF SequenceStartStop




NANANA