<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31283

Description Cyclin C-dependent kinase CDK8
SequenceMNPHHAAPIAAAGVASTSEAPSTQPHGYYYDNLDDPYAGAFWSHFRQPHELAARHVPLDASPAATMKAYREYRDRVRKPVLATYTILGFLSSGTYGRVYKARLRTDPQLPPTSGSAAAGLATPTASGAANVATAAAKKRGGLLQQHQLLDSPSAASSLHPTPKSVIDLTAPANATPGRTRTDSPGIVAAAAATTTHTTTTTGGAAISRTADNSSVTTALGGGDGQIFAIKKFKPDTKETDATVYTGISQSAMREISLNRELSHVNIVTLRQVMLEDKAIYMVFEYAEHDLLQIIHYHSTALRTPIPTAVLKSLMWQLVNGVAYLHANWILHRDLKPANILVTSNGVVKIGDLGLARLYSSPLQSLYNGDKVVVTIWYRAPELLLGARHYTTAIDMWSVGCIWGELLALRPMFKGEEAKMDPKTKAAPFQTDQLKRIVEVLGTPNKERWPAIESMPDYKGWWPHLRLDNYPKTLSRWYTSRHKSEDGYDLFDDLLQYDPEQRLTANQALAHGWFAHEPQVTLNAFASLAKPVGTYPNRRVIHDDLDPKMKSNYQPPIDAHHLPAIQQANLNSAHPIRLAQLLHRQHHLSQQGSGGEAGKASVGSTGPAAPPALGTVGMQTSAPSTAPSLQPNPPLITIAHPPSSTPTVRSTHSLQSGTDDSPAANSARSTLVATAARNNQRKRQRI
Length685
PositionKinase
OrganismPseudozyma antarctica (strain T-34) (Yeast) (Candida antarctica)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Moesziomyces.
Aromaticity0.07
Grand average of hydropathy-0.371
Instability index44.89
Isoelectric point9.42
Molecular weight74330.13
Publications
PubMed=23558529

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31283
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.48|      16|      17|     170|     185|       1
---------------------------------------------------------------------------
  112-  127 (20.95/ 7.68)	TSGSAAAGLATPTASG
  170-  185 (30.16/14.12)	APANATPGRTRTDSPG
  188-  203 (24.38/10.07)	AAAAATTTHTTTTTGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.23|      13|      25|      69|      81|       2
---------------------------------------------------------------------------
   69-   81 (25.11/16.03)	Y.REYRDRVR.KPVL
   95-  109 (16.12/ 7.89)	YgRVYKARLRtDPQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.70|      17|      22|     610|     629|       4
---------------------------------------------------------------------------
  610-  629 (24.39/18.95)	PALGTVgmqTSAPSTAPSLQ
  632-  648 (32.31/16.32)	PPLITI...AHPPSSTPTVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.04|      18|      22|     494|     513|       5
---------------------------------------------------------------------------
  459-  474 (23.08/13.12)	GW.....................wPHLRLDNYPKTLS
  475-  510 (21.74/15.71)	RWYtsrhksedgydlfddllqYD.PEQRLTANQALAH
  511-  529 (27.22/16.95)	GWF.................aHE.PQVTLNAFASLAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.87|      22|     508|      30|      57|       7
---------------------------------------------------------------------------
   30-   57 (30.26/29.92)	YDNLdDPyagAFWSHFRQPheLAARHVP
  541-  562 (44.61/22.02)	HDDL.DP...KMKSNYQPP..IDAHHLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.53|      21|      29|     351|     376|       9
---------------------------------------------------------------------------
  351-  376 (30.80/33.74)	DLGL.ARLYSSPLQSLyngdkVVVTIW
  381-  402 (36.72/24.58)	ELLLgARHYTTAIDMW.....SVGCIW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31283 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AHPIRLAQLLHRQHHLSQQGSGGEAGKASVGSTGPAAPPALGTVGMQTSAPSTAPSLQPNPPLITIAHPPSSTPTVRSTHSLQSGTDDSPAANSARSTLVATAARNNQRKRQRI
2) GGLLQQHQLLDSPSAASSLHPTPKSVIDLTAPANATPGRTRTDSPGIVAAAAATT
3) PNRRVIHDDLDPKMKSNYQPPIDAHHLPAIQQANL
572
140
535
685
194
569










Molecular Recognition Features






MoRF SequenceStartStop




NANANA