<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31282

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMASSEAGPSRPPASSEVHISIEPVHIYTDPDIASSSLGPPSGIAAAFERERKLQDISADGTNIFATRAAASEQLSQDVHRLWAERGDFSRFRTADLLRKRERDTSPEAQSDDDEHSPAGEEKDDEEPLPRPADEVVGGTIGEAEFVALRNKVLANLDVAHFNSIHAHQLLGMLLKQHRAPSAAANTAAAGRMGSPAPSVGGQSARSGTNTAARAPLGIFAHLAPSSREEEFVLDPLAISLSRTALNASAAARRSARDDMDEDSDDDDPRSAGYGLKQARREMEAAAAFKHARLRDLKVVLETKRAATRNAADLLSSAAAELRASQASNRERWRALIGLHARGWRLTPGRPLLDVERFGATSDEEEPTEDPEADADAGAKAGEEKKKKPAGLQGFGTPIITSDGKVKDEGARDAWIGFGLPEAPVELRRRSLAYWADASSAAAAPEEVKQKLVFPDRMHRRLRVRFVLWRATSSGEERMEWTSDQPTSSAESDARVGVGQVLDEELQSASREASDELVFGDVVAQARALPPAFGVRLTPSSVRVVLTPRLDMILELVSTCTECTGKYAAQAQAVVALVRMGVIRKFHAFVQATRLARRADAPSRAAAIKAHALAVPKTAAKADTTTTLARMDSLGPLLVALHYVSFLHRLQRVLNHVQGELQQKGVGMRVQMVPIVAEGGLRAMMTRWVEAAHSQPTDLHTLYASKQRSESLHGYAKLFATTQGAERLAATITFKQPSAVTVQFNARPRAPRTKLTTDPLPVDLETLPTLLLHHLT
Length775
PositionHead
OrganismPseudozyma antarctica (strain T-34) (Yeast) (Candida antarctica)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Moesziomyces.
Aromaticity0.05
Grand average of hydropathy-0.385
Instability index51.32
Isoelectric point6.65
Molecular weight83858.43
Publications
PubMed=23558529

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31282
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.73|      12|      14|     179|     190|       1
---------------------------------------------------------------------------
  179-  190 (20.07/ 8.50)	APSAAANTAAAG
  196-  207 (21.66/ 9.72)	APSVGGQSARSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.99|      15|      49|     565|     579|       2
---------------------------------------------------------------------------
  565-  579 (24.97/17.15)	KYAAQAQAVVALVRM
  616-  630 (25.02/17.19)	KTAAKADTTTTLARM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     366.34|      98|     238|      44|     142|       3
---------------------------------------------------------------------------
   44-  142 (165.15/78.02)	AAAFERERkLQDISAD.G.TNIFATRAAAS..EQLSQDVHRLWAER.GDFSRFRTADLLRKRERDTSPEAQSDDDEHSPAGEEKDDEEPLPRP.ADEVVGGTIGE
  208-  272 (62.52/24.02)	..........TNTAAR.ApLGIFAHLAPSSreEEFVLDPLAISLSR.TALNASAAA...RRSARDDMDE.DSDDDDPRSAG........................
  285-  382 (138.67/61.94)	AAAFKHAR.LRDLKVVlE.TKRAATRNAA...DLLSSAAAELRASQaSNRERWRALIGLHARGWRLTPGRPLLDVER..FGATSDEEEPTEDPeADADAGAKAGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.99|      25|     248|     470|     494|       5
---------------------------------------------------------------------------
  470-  494 (44.88/30.93)	ATSSGEERM..EWTSDQPTS.SAESDAR
  719-  746 (34.11/21.57)	ATTQGAERLaaTITFKQPSAvTVQFNAR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31282 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAARRSARDDMDEDSDDDDPRSAGYGLKQAR
2) DVERFGATSDEEEPTEDPEADADAGAKAGEEKKKKPAGLQGFGTPIITSDG
3) MASSEAGPSRPPASSEVHISIEPVHIYTDPDIASSSLGPPSGIAAAFERERK
4) MLLKQHRAPSAAANTAAAGRMGSPAPSVGGQSARSGTNTA
5) TADLLRKRERDTSPEAQSDDDEHSPAGEEKDDEEPLPRPADEVV
249
353
1
172
93
279
403
52
211
136










Molecular Recognition Features






MoRF SequenceStartStop




1) AAFERE
2) EVHISIEPVHIYT
3) FVLWR
45
16
465
50
28
469