<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31277

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAHTPGAFAAHARSNSLANSPSAHRRAGAMAPVQHASSPSTTSASSRLHTNTPFPGTVAAPRSAMPPASASAHLRSMQYLSRLTERTPASFVKLPFPSNTTVHWLRLQKPDSHPPPELGQDHTQPDTAAPAGATSTSTNQSQGRDTVWTNAVHQILTNSKNVQAGSRNDDNTQTTPDDAFERLVRRTLVYTSALRPVTADSLDASTADSSIYASVSDLWLFAAVNDDDSGPPGKTSSAVGPTAAATTTNAAQTQGIAQSAGVDDVILNAAHQQTTPTNPTVSSLPAVARWLPSESVKALARLFESATVDGGSYLLSSACPSSRDNKGKQSVLTSQQNQAHRHFMETLKTRASSIFAQESLPPFSSSPAGELGTSTSSTSSPTLRRRLRLGDSVIFLPPAADIAALPSQVHGKSASSPRPGAPTVSTDLYCLAAELHLSLCRSSLLLRTTSRRLAALPLASTPRGQHEAPPLLHEARPQLHLAPLGQRAELIHVVSSDSIASDHLSQLRTLFASLDLGSGNGMGIQPVEVDLLASGIAVCALPPALAEAHASAGDASHPLEQTHEASFAAYPHIQAIDDDMGLDLLDAPGFGEQTQRPQQRSSEDRRFLWPVSLCLVALDPRRAAWSSSWPGASATNDLHTIRSEPVTPLKELVSFTLKVLNDANESVAAQSAPPFTPGEPDDVSLTRHRGERISSARPGITPASMSFADFDLAMPSAASVTPSQSLPTVPRTDSQTSPEKREHAGAEAGPSTNSADQQFADDLSWMEFLPQATGEVPGAAASAAAMPASSVPIGSAPTAVPPASSTVPAAQAAGQVKGLDLDPSGSNWAFATSLDAGGDNVNHLEAKQDPASLAAQALLQPQGRLHSSGSTPFQGQAATPLSFGQTQTKRKGEGDIFGNLGLLTEDDFSFFDESAFGLESPSALAGEQGAMSSHLDPSGVSQADVSANATAHQHGLGRGETSARDPSGGAAAQATSMSATSAGIGDVEMEDLEATNLDALFGAIPSMQDVMGAESSQMRASEPPPHSAVSAAAAPSQIVASAAAHDTAGATAASSSQAMPPVTVSFTPRSVSAATPFGDPASLPGFTPSSLTESSPAFGHANHKTPRTPFSPVEEYRDGAAIVGSEAGNHHAGESAQLDGRYAHLAPQDQAGFPAAAGSKLESQEEGGQLRLADASSAAAAAANAAMSTDPFNKKRPAIVPSAFLPLTQPQARKPLQRLTMGARANLGRKYDLFGKFASRPKSTAVLHALPNAANALSPDQNVQDEGKGDSASFSSRFALRPSRASPPKAVARRGQALLQLRRDRNSKMSPGQAVTTGGRHGGQRGLDAASTPRSSDDIAIARRASVSDSDSSSSEDDDEASDDAHSDSDVTEVTLSPEDQESMKRCSRHIIASYLCGAYGTSSEGEATGSHQPAALLNPATTSSPMLWPGSAAIASSTYPTIKRSMLSRTARWLLENPQFRSMYSRAVDAGSDGSDIATREKLEVLAAMACALRITHGSETKPSTQSSTHSDGFLEQEALPTLQGLVVNAASSRAIQATEGNVVQAEVLEPTSIAVGCQGSVVEALPSALSLWDKSKLSAVSGHKHVVAKVLLTHASPAWHDEIVAWLERLRAAFEAYGLGTHTGSAGSILVMADGSEPLALSSYLERLWRDGDAWLDTLRSIASRVDMDVLQGRHVVIYALQPPGSTTCAASGFRGLLQLEADLRVMLAEQVGVLAEHLIVRPISPAMMTESGSLGFGQQSDAIRRLAFSVYDQLPRLVRRQPAKVLHGREPGPISAIVQFPAFSLATGLGRTNFSLSWPREPTTAVDEALMLHVSYRACADGAAKMVVVSAMDERGGSSDVDVLVGDAEGWIGQVWRYAIGQASRARLSWRLVISSTVPMSRQEQAGWHSCVEAYFTRTQGGKLAVGSVVLLCVRPDEAGAILADVGARTRPSTEPGQVDKSRSVLMDASDCSQVLQFTEPLPLDWTMPFASPEEMASSTASAILVHRPSSAGGRDMASHVLGVDVLQTWREKEAVMADVLASLHALRLVAEQRHQITAPPGLPWGIAAVNMLAQLIGRAVVVD
Length2067
PositionKinase
OrganismPseudozyma antarctica (strain T-34) (Yeast) (Candida antarctica)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Moesziomyces.
Aromaticity0.05
Grand average of hydropathy-0.244
Instability index52.49
Isoelectric point5.74
Molecular weight216388.57
Publications
PubMed=23558529

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31277
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     204.43|      41|      41|    1067|    1107|       1
---------------------------------------------------------------------------
  966- 1016 (30.67/ 9.50)	PSGGAA..AQAT........SMSAtSA.......GIGDvemedleatnlDA.LF...GAIPSmqD..VmgAESS
 1067- 1095 (39.64/14.87)	................TPR.SVSA.AT.......PFGD...........PASLP...GFTPS..S..L..TESS
 1096- 1136 (32.78/10.76)	PAFGHA..NHKTPR.............tpfspveEYRD...........GAAIV...GSEAG..NhhA..GESA
 1137- 1164 (31.94/10.26)	QLDGRY..AH......................laP.QD...........QAGFP...AAAGS..K..L...ESQ
 1202- 1243 (37.44/13.56)	SAFLPL..TQPQARkpLQRlTMGA.RA.......NLGR...........KYDLF...GKFAS........RPKS
 1244- 1291 (31.95/10.27)	TAVLHAlpNAANAL..SPD.QNVQ.DE.......GKGD...........SASFSsrfALRPSraS..P..PKAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     589.85|     139|     142|     276|     417|       2
---------------------------------------------------------------------------
   14-  119 (101.20/37.03)	........................................................SNSLANSPSAHR..RAG.A....MAPV.QH.ASSPSTTSASSrlhTNT.P...fPGtvaAP..RS...............AMPPASASAHLRSMQYLsrLTERTPASfvKLPFPSNttvHWLRLQKPDSH...PPPeLG..
  208-  350 (161.59/69.55)	DSSIY.......ASvsdlwlfaavnddDSGP..PgKTSS........AVG.P.TAAATTTNAAQTQGIAQSAGvDDVIL..NA.AH....................qqttPT...NPTVSS.LPAVARWLPSESVKALARLFESATVDGGSYL..LSSACPSS..RDNKGKQ...SVLTSQQNQAHrhfMET.LKTR
  351-  487 (205.96/84.14)	ASSIF.......AQ.............ESLP..P.FSSS........PAG.E.LGTSTSSTSSPTLRRRLRLG.DSVIFLPPA.ADIAALPSQVHGKS...ASS.P...rPG...APTVSTdLYCLA....AELHLSLCR..SSLLLRTTSRR..L.AALPLA..STPRGQHeapPLLHEARPQLH...LAP.LGQR
  488-  558 (48.98/13.01)	AELIHvvssdsiAS.............DHLS..Q.LRTL........FASlD.LGSGNGMGIQPVEVDLLASG.IAVCALPPA...LA..EAHASAGD...ASH.P...........................................................................................
  717-  809 (72.13/23.42)	AASVT.......PS.............QSLPtvP.RTDSqtspekreHAG.AeAGPSTNSADQQFADDLSWME.....FLPQAtGEVPGAAASAAAMP...ASSvP...iGS...APT..A.VPPASSTVPA.................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.61|      38|      42|    1362|    1403|       3
---------------------------------------------------------------------------
 1361- 1401 (60.11/33.69)	ASDDAHSDSDVTEVTLSPEDQES.MKRCSRHIIASylcGAYG
 1403- 1441 (58.50/29.03)	SSEGEATGSHQPAALLNPATTSSpMLWPGSAAIAS...STYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.71|      14|      42|     810|     826|       4
---------------------------------------------------------------------------
  810-  824 (21.09/10.13)	AQAAGQVKGlDLDPS
  855-  868 (21.62/11.00)	AQALLQPQG.RLHSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.01|      39|      41|    1672|    1711|       5
---------------------------------------------------------------------------
 1637- 1666 (24.97/ 9.83)	...............GSEPLALSSYLERLWRDGDawldtLRSIAS
 1672- 1711 (62.68/43.97)	VLqGRHVVIYALQPPGSTTCAASGFRGLLQLEAD.....LRVMLA
 1716- 1740 (32.36/15.83)	VL.AEHLIVRPISPAMMTESGSLGF.G..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.62|      39|      42|    1459|    1499|       6
---------------------------------------------------------------------------
 1459- 1499 (60.79/42.38)	PQFRSmySRAVDAGSDGSDIATREKLEVLAAMACALRITHG
 1504- 1542 (64.83/38.35)	PSTQS..STHSDGFLEQEALPTLQGLVVNAASSRAIQATEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.92|      36|     630|     918|     954|       8
---------------------------------------------------------------------------
  918-  954 (58.78/37.76)	LESPSALAGEQGAMSSHLdPSGVSQADVS..ANATAHQH
 1550- 1587 (59.14/33.28)	LEPTSIAVGCQGSVVEAL.PSALSLWDKSklSAVSGHKH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.01|      29|     200|     674|     711|       9
---------------------------------------------------------------------------
  172-  202 (44.54/20.36)	TQTTPDDAfeRLVRRTLVYTSALRP.VTADSL
  676-  705 (48.47/40.12)	TPGEPDDV..SLTRHRGERISSARPgITPASM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      54.07|      10|      32|    1750|    1759|      12
---------------------------------------------------------------------------
 1750- 1759 (19.24/10.79)	AFSVYDQLPR
 1785- 1794 (17.58/ 9.09)	AFSLATGLGR
 1796- 1803 (17.25/ 8.74)	NFSL..SWPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.86|      20|     140|    1032|    1051|      14
---------------------------------------------------------------------------
 1018- 1037 (35.92/18.79)	MRASEPPPHSAVSAAAAPSQ
 1038- 1057 (31.94/15.63)	IVASAAAHDTAGATAASSSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.98|      11|      22|    1328|    1338|      15
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 1328- 1338 (19.14/11.49)	DAASTPRSSDD
 1349- 1359 (18.85/11.15)	DSDSSSSEDDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31277 with Med13 domain of Kingdom Fungi
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