<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31229

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPQQNTIEHSFATAYHHEAWTCSIENTIIPGELQTVSWFQFLPVEPEYNATSDRSSKAEQKDALNSTVLSAYLRLQSEGLLSTWTNSFVGPWDPSQGEHNPVVSSDLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGDVFTKYNPPTRNQNSFRRAQPTVEFVFAATEEAIFVHVIISASFFIVYVNYVLCLFGFIVAPSGMLGRLVGCCPSDLARQVYSSKLSAPNLPGFTQPTICQLRGQSYYVEVALGFPPASTDKISESENNQIKKEFDSVKDLHLGDDGQQKLESADGLPVLERTFIYPPEAVMVPMVHQAFVRFSSKRMWSQDWMGSSSWEAWPFWNFSPSSYFRNRTCYCFIPRKREDLEELATNFIQIFSKLLSSFFGSSRGLGVNSNFLRLRRQRNNNSNGMTSSISSVSSTSNGSEHAVAAKGGDLLADADSTACHQSDLPLNNDIAGSKMVSKRSRSEITEDSSHAGKEVSENMQGTNGQGGCSWGWGEEGVVMDINILLLEFGDFSDFFQEDELDFGEPPGTAESHALVSPASEFGDMPFIDSPSVAMDIPEQRLSPVGFTSMEAFNHQTMSPIQDVASKVQEPLKEIASPAGSQSLVLSSSRSDFLTRAEATLTFAPEYAAVEISSCETPATLFTNPYLPGSKKRGSCGFSSRVYSYDVTQSSKVESAGDKSEKSDKLTPANLSRDVGRSSLYTLVQGRKNESEKSLNSADEQSCKGETSRPVSGETSFSSSLTIQKKSDSMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSALSSAMQTESSSNSGLVPKYEMKRKESIPARLSSDVDHDMYDRSQLESVGVWRSVVVPKGAKPLDSLSTKTFTGISPSVQRQPIVKLLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESAVMGDAYSFHYSTGDIRDTSNSIPIGGDAMSPPQSSNDRGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPVTYYALCPDIDMLTSAATDFFMQLGTIYEVCKLGTHSPQHSGGQIEQSPGKYLPSGLVLVECPDQLKTRGSHSVSISSVTEYFQALSKSWSVKSFVSSLARIIKDIKLTLNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVAIGSILSSERERKSFLYTQVAKALDSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLHKPNELAAFKDIAFTVYNKARRIPRFVSTSDMFQSPTYMSRPQSMMMHTASPGPTLWKECLAPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGAVDYNDTMESSRFGVDASSSRVYSSISGGTDSGASPLLEGETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGTADYSDIMESSRFGADASSSRAYSSISGGTDSGASPPLEGSENDSGTSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTKVLQSLFIQILQQGCQIMSSSPEASNTRSRDVIITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPPNSNGPTLQQQDMGLIQDRNMPSSPSTLYSPHSKSSFTKGQSGNKKQILVEQSGMDSSRGSLHLVRSISLVAVSQDSSLHLACQADLIATRPTSGEGNQSSTGSSSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKNAAQLTKEDRHSVLSVSIVDYYGGSTPTVQEKMSRGVGGSTMSKQARNITHETSARDYEMDMHNVLEAVAAELHALSWMTVSPVYTERRSALPFHCDMVLRLRRLLHYADRHLSQLTEKGEM
Length2009
PositionKinase
OrganismTriticum urartu (Red wild einkorn) (Crithodium urartu)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.08
Grand average of hydropathy-0.291
Instability index58.71
Isoelectric point5.45
Molecular weight219540.28
Publications
PubMed=23535596

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31229
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     528.06|      91|      91|    1396|    1486|       1
---------------------------------------------------------------------------
 1230- 1288 (53.99/26.92)	.....................................................SNIP....CT...VVYVVCP...FPEPSAV.LQTLVESSvAIGSILSSERerksfLYTQVAKALDSSASA....
 1290- 1377 (71.75/38.66)	.......EASAS...NVVmlsgfsipklvlqivtvetllrlhKPNELAAFKD...IA..FTVYNKARRI...PRF.......VSTSDMFQSP.TYMSRPQSMM.....MHTASPGPT......LW..
 1396- 1486 (184.11/112.90)	FDASM.RSVSWD...NSW........................QPGRAVGLPDPSKIP..ELCAQDDRKYAFEPLFILAEPGAVDYNDTMESS.RFGVDASSSR.....VYSSISGGTDSGASPLLEG
 1490- 1580 (183.62/112.57)	FDASM.RSVSWD...NSW........................QPGRAVGLPDPSKIP..ELCAQDDRKYAFEPLFILAEPGTADYSDIMESS.RFGADASSSR.....AYSSISGGTDSGASPPLEG
 1589- 1638 (34.60/14.11)	LHCCYgWTEDWRwlvCIW........................TDSRG.ELLDSLIFPfgGISSRQDTK.VLQSLFI...................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     246.73|      77|     111|     200|     283|       2
---------------------------------------------------------------------------
  200-  283 (122.46/84.28)	FIVAPSGML.....GRLVGCCPSDLARQ..VYSSKLSAPNLPGFTqPTiCQLRGQSYYVevalgFPPASTDKISESENN..QI.....KKEFDSVKDL
  306-  396 (124.27/68.94)	FIYPPEAVMvpmvhQAFVRFSSKRMWSQdwMGSSSWEAWPFWNFS.PS.SYFRNRTCYC.....FIPRKREDLEELATNfiQIfskllSSFFGSSRGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.83|      42|     111|    1700|    1742|       3
---------------------------------------------------------------------------
 1700- 1742 (72.90/47.50)	SIPDGIPPNSNGPTLQQQDMgLIQDRNMPS.SPSTLYSPHSKSS
 1812- 1854 (69.93/40.74)	SYLDGFAPVKSIGSMSASYL.LVPSPSMRYlSPATLQLPTCLTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.52|      22|     111|     432|     456|       4
---------------------------------------------------------------------------
  432-  456 (33.33/30.70)	HAV...AAKGGDL.LADADSTAchqSDLP
  543-  568 (32.20/18.96)	HALvspASEFGDMpFIDSPSVA...MDIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.43|      36|      91|    1054|    1089|       9
---------------------------------------------------------------------------
 1054- 1089 (65.48/43.62)	GTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKT
 1111- 1133 (31.75/16.75)	VT.......YYALCPDIDMLTSAATDFFMQ......
 1144- 1178 (61.20/40.21)	GTHSPQHSGGQIEQSPGKYLPSGLVLV.ECPDQLKT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31229 with Med13 domain of Kingdom Viridiplantae
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