<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31226

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMMMGELQTVSWFQFLPVEPDYSATSDRSSKAEQKDALNSTVLSAYLRLQNEGFLSTWTNSFVGPWDPSQGEHNPVVSSGLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGDVFTKYNPPTRNQNSFSNLCNVSVKVQMLCTTIDSVWRAQPTVEFVFAATEEAIFVHVIISARYMRNLSSDDIEKVLTHIPRSVGEGLPVIVAPSGMLGRLVGCCPSDLARQVYSSKLSAPNLPGFTQPTICQLRGQSYYVEVALGFPPASTDKTSESENNQIRKELDSVNDPHLGADGQQKLESADGLPVLERTFIYPPEAVMVPMVHQAFVRFSSKRMWSQDWMGSSPWEAWPFWNFSPSSYFRNSSFFGSSRGLGVNSNFLRLRRQRNSNSNGMASSISSVSSTSNGSEHAIAAKGGDLLADADSAACRQSDLPLNNDIAGSKVVSKRSRSEITEVSSHAGKEVNMQGTNGQGGCSWGWGEEGVVMDIDILLSEFGDFSDFFQEDELDFGEPPGTAESHALVPPASEYGDMPFIDSPSIAMDIPEQRLSPVGFTSMGAFNHHTMSPIQDVASKVQEPLKEIASPAGSQSLVLSSSGSDFLTRAEATLTFAPEYAAVEISSCEMPTTLFTNPYLPRSKKRGSCGFSSRVYSYDVTQSSKVESAGDKSEKSDKLTAANLSRDVGRSSLYTLVQGRKKESEKSLNNADEQSCKGETSRPVSGETSFSSSLTLQKKSDNMLNVGYFLLSMKTALATEIECITFQAAMCRIRHSLVSLRTKASAELKSALSSAMQTESSSNSDLVPKYDMKRKESMPARLSSDVDHEMYDRSRLENVGVWRSVVVPKGAKPLDSLSAKTFSGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSTIAESAAMGDAYSFHYTTGDIRETSNSVPIGGDAMSPPQSSSDRVTDLWEKAPLEPYASAKPVTYYALCPDIDMLTSAATDFFMQLGTEFVPYFYLFCILIVYEVCKLGTHSPQHSGGQIEQSPGKHLPSGLVLVECPDQLKSSGSHSVSISSVTEYFQALSKSWSVKSFLSSLARIIKDIKLTLNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVALGSILSSERERKSFLYTQVAKALNSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLHKPNELAAFKDIAFTVYNKARRIPRFVSTSDMFQSPTYMSRPQSMMMHTASPGPTLWKECLAPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGAVDYNDTMESSRFGVDASSSRVYSSISGGTDSGASPLLEGSENESAASLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTTVLQSLFIQILQQGCQIMSSSPEASNTRSRDVVITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPSNSNGPTLEQQDMGLIQDRSMPSSPSEGNQSSSTGASSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKQLTKEDSRHSVLSVSIVDYYGGTVQDKMSRGSKQAVRHETSGRDYEMDMHNVLEAVAAELHSLSWMTVSPVYMERRSALPFHCDMVLRLRRLLHYADRHLSQLTDKGDVS
Length1783
PositionKinase
OrganismTriticum urartu (Red wild einkorn) (Crithodium urartu)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.08
Grand average of hydropathy-0.254
Instability index58.99
Isoelectric point5.40
Molecular weight194677.12
Publications
PubMed=23535596

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31226
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.95|      61|      98|    1292|    1358|       1
---------------------------------------------------------------------------
 1292- 1358 (104.29/58.33)	PRFVSTSDMFQSPTYMSRPQSMMMHTASPGPTlwKECLAPRMSGQtlsrETEFDASMR.SVSWDNSWQ
 1393- 1454 (103.66/46.46)	PGAVDYNDTMESSRFGVDASSSRVYSSISGGT..DSGASPLLEGS....ENESAASLHcCYGWTEDWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.08|      43|      97|     488|     535|       2
---------------------------------------------------------------------------
  488-  535 (64.60/47.75)	ILLSEFGdfSDFFQEDE..LDFGEPPGTAESHALVPPASEYGDmPFIdsP
  588-  632 (70.49/36.41)	LVLSSSG..SDFLTRAEatLTFAPEYAAVEISSCEMPTTLFTN.PYL..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.40|      28|      98|    1081|    1113|       3
---------------------------------------------------------------------------
 1081- 1113 (44.89/38.26)	CiLIVYEVCKLgthsPQHSG...GQIEQSP..GKHLPS
 1182- 1214 (41.50/21.79)	C.TVVYVVCPF....PEPSAvlqTLVESSValGSILSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     361.23|     116|     566|     952|    1080|       4
---------------------------------------------------------------------------
  952- 1080 (183.81/129.46)	GLLQSDIKSALKTAFANmdGPLSVIDW.CRGRSTIAE...SAAMGDAYSfHYTTGDIRETS.NSVPIGGDamsppQSSSDRVTDLwekapLEPYASAKPV....TYYALCPDIDM..LTSAATDFFMQLGTEFVPYFYLF
 1523- 1649 (177.42/96.97)	GFLELEIQEWQKAIYSF..GGNEVKKWpVQLRRSIPDgipSNSNGPTLE.QQDMGLIQDRSmPSSPSEGN.....QSSSTGASSY.....LDGFAPVKSIgsmsASYLLVPSPSMryLSPATLQLPTCLTSESPPLAHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.33|      32|      66|     639|     670|       5
---------------------------------------------------------------------------
  639-  670 (52.91/37.72)	SC.GFS...SRVYSYDVTQSSKVESAGDKSEKSDKL
  672-  704 (32.00/18.92)	AA.NLSrdvGRSSLYTLVQGRKKESEKSLNNADE..
  706-  734 (40.42/26.49)	SCkGET...SRPVSGETSFSSSL....TLQKKSDNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     302.08|      98|    1397|     259|     383|       9
---------------------------------------------------------------------------
  259-  383 (143.09/136.81)	ALGF......PPASTDKTSESENNQIrkeLD.SVNDpHLGADGQQKLESADGLPVLERTFIYPPEAVMvpmvHQAFVRFSSKrMWSQDWMGSSPweawpfwnfspssyfrnsSFFGSSRGLGVNSNF.LRLRR
 1659- 1764 (158.98/90.75)	AMGYvvskavPPVRKQLTKEDSRHSV...LSvSIVD.YYGGTVQDKMSRGSKQAVRHETSGRDYEMDM....HNVLEAVAAE.LHSLSWMTVSP..................VYMERRSALPFHCDMvLRLRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.10|      29|     394|     394|     448|      16
---------------------------------------------------------------------------
  415-  443 (48.76/59.48)	GDLLADADSAACRQSDL..PLNNDIAGSKVV
  921-  951 (46.35/11.77)	GGLLGTCHSKDCAGVDLvdPLSAEVSESSMI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31226 with Med13 domain of Kingdom Viridiplantae
Unable to open file!