<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31201

Description Putative mediator of rna polymerase ii transcription subunit 22 protein
SequenceMSRDHDLWNSSRGEAIGTAPGNSVETSDSTRINEDAVIDSSAPSRPGLTSRAISSDFIGTDEGNVASFLAPPGSEHMSGAPASNPTSHPARINDSSVTDLLNSTVPEYNSRVPSSDFVVNHWPVSESSMVQSIEAVATEPISSIPGPEAVTPYSSSHQLEMMPLQPIDALTYGFDLPPHPIESTGEIIINSSLLNEVAAEEPLGFVEPAFESITLHQGIASLGLPNEVTAASGLILDNGMLRQEGSSAQMIQNDLHMKDSLDFENISIPDLLNEVTATAKPISNSGTLGQEDPYAQVVQNDVSLENLLGDGNDSRLSFLDAFAANQFTEFPDLVFDNGMLHQDEPPPNFPHEVTAITEPVPNKKAASITGLIASNEVTAVTEPVAEDGRPSRNDLIHKHEPVAEDERPSRNDRVHKHEPVHNDDLADGPAVLRASKADKLTDRQERAIAALLIRFQNLVKLAALPTEDAFTKETAAAEGLRMEVESNALTSAAEDLLKLTRELKEFWIFGSLRGIGEGEGDGEMETDSKKVAELIEKQLEKKHEQEKNKA
Length550
PositionHead
OrganismBotryotinia fuckeliana (strain BcDW1) (Noble rot fungus) (Botrytis cinerea)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Botrytis.
Aromaticity0.04
Grand average of hydropathy-0.428
Instability index48.75
Isoelectric point4.49
Molecular weight59314.85
Publications
PubMed=23704180

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31201
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.28|      14|      15|     387|     401|       1
---------------------------------------------------------------------------
  387-  400 (27.77/11.50)	DGRPSRNDLIHKHE
  405-  418 (25.51/11.42)	DERPSRNDRVHKHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     256.75|      71|      76|     141|     215|       2
---------------------------------------------------------------------------
   72-  140 (42.22/22.93)	...PGSEHMSgaPASnpTSHPAR..INDSSVTDLLNstvpeYNSRVPSsdfvvnhWPVS........ESSMVQsiEAVATEP.............
  142-  215 (122.12/91.30)	SSIPGPEAVT..PYS..SSHQLE..MMPLQPIDALT.....YGFDLPP.......HPIESTG.EIIINSSLLN..EVAAEEPlgfVEPAFESITL
  220-  288 (92.41/64.24)	ASLGLPNEVT..A.A..SGLILDngMLRQEGSSAQM.....IQNDL.........HMKDSLDfENISIPDLLN..EVTAT.....AKPISNSGTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.44|      11|      23|     352|     362|       3
---------------------------------------------------------------------------
  352-  362 (21.45/13.52)	EVTAITEPVPN
  376-  386 (19.99/12.10)	EVTAVTEPVAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.95|      24|      25|      20|      43|       4
---------------------------------------------------------------------------
   20-   43 (40.83/23.04)	PGNSVE..TSDSTRINEDAVIDSSAP
   46-   71 (37.12/20.34)	PGLTSRaiSSDFIGTDEGNVASFLAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31201 with Med22 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DEGNVASFLAPPGSEHMSGAPASNPTSHPARINDSSVTDLLNSTVP
2) EVTAVTEPVAEDGRPSRNDLIHKHEPVAEDERPSRNDRVHKHEPVHNDDLADGPAVLRASKADK
3) GEGDGEMETDSKKVAELIEKQLEKKHEQEKNKA
4) MSRDHDLWNSSRGEAIGTAPGNSVETSDSTRINEDAVIDSSAPSRP
61
376
518
1
106
439
550
46










Molecular Recognition Features






MoRF SequenceStartStop




1) METDSKKVAELIEKQLEKKHEQEKNKA
524
550