<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31194

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDLGDQPTNVLCCDNFASITYEYFEPQWPSPSSITKKHLQDVETAWRNHGNLVYYDAKREGIWVFQPSPNSPNKALDEGDDSLSQANLPSVRGVELVKKDKGTYEPSYLAKSKSMLAASLNTPNSASSPSPLENALRNAQNVNARAMQVNSAQNLHDPAGSSPGVKSVASIGDTFAFLKEVQEHFISSVQGSIMYKLCNDHGLIPLNSRTLLLPSESPSRSMAYYQSPKVSDDTVTLVDLDISLTSLGALMIKACSYVTPGLQSINHTSPEKLQRILSQGTELWLAPGGNPAKFYSFYDDEQLPGIQPISDLQKYPEDHSWRFHGTTIKSWQSRCLDWLSTKGFDSSLIDEGGWMFVQVLNTNYGSSNPEYADIPSSDEGAIVPWPTLLCFRAIKTSTTDLQPSSANSFGLVDPLTFVEDWSMNAEERASIMSNRQQERNVLKAAKEQADQEAQNIRANNHSTALLEKGSNAGAMYPTPPDAIHHPGGPTPSFDGAVTTPGNPAHLFSHDLETTNPSTSIMNTADTDNWVTSEQKHRSNSNMNFEENENDNDNLFGDMGGDLFGDTDITDADFNFFDQPDDIEMEHQSGSAVEPNLPPAPQHKIVEKSSVSSKPLVPQPTSKDTIMKDSQPTENNKRQPTFDQRFATSEMDMDVEMSNNNDNLIASAQPPLPPRIVAPFDKEIVFGQLARRKRKRKSKSQSSSGSSEFDEVKFEYSLTEVDEKYGYNGRFRYSDDDLKPQLVEPHDPTNPESFGRRKSENKALESDVLSRILNNDNAQYEFELDNEAELDVASESNSISDASESDDALPTGVSAIVKLGMKGKRYFDEASISSYNAFTGEYEPSAGTPQSIIEPHIPIFESDPADWSLTPYFTSPEPDIQPSGLSDLDLIETAQIIADQAAPGTLRVNDQICQNPDAHDQATFATRRLMTDVLQATKVCLKDVKSCTLRSYLTIPGIPAVNAALRLPPQGRPMPNPRAAQQTDPSKSSNPFPIQPPQLEVRRGDSKLAVLPPAIHFWDNLGLAPYTGNKDVNAVCIYPNIVGINENADIFLDQMRGAYESFRFGGHDRIMFPESPSGLLNYPCDVNTNKAAYLSSLKDVLTRLGKNLSSMTTEEKNVVVYFVYPLNNSSLLVNICTAFKHLFKVYRKSLSEKKLKIYNELVLQLVPLDFMAAPNSLIVPSPAEYSRLAMEVYDRCVDFASSSTTAAILLEKPLPRNIDFKLNINPSPALLQENSCLHIAYAQSIDERWITAAWSDNRGTKQMTASYCLGRKNEPFTLLFTDVANEIWETTLDLISSKKVHWRIIIAKTAVMEQSEIDFWTGLASTESNGSISLTLVTVQTDPSLRILPPQIRIPPPSMTTSQPTTTPVSTPQASQSSVFSPGNASTPTANAPTPSEAQSTSTPAVPPEPDDQSSRLLDITDQTWGAILSHRLNNSNSLLEFNPALISGYLVKNSGTSTDDPPIVLEVNIIYAEVVGNPRTFHDTLLREILGYYRGLATLARVRGVVHPVRDGRPWHIAAAEKAVKALYMLL
Length1531
PositionKinase
OrganismBotryotinia fuckeliana (strain BcDW1) (Noble rot fungus) (Botrytis cinerea)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Botrytis.
Aromaticity0.08
Grand average of hydropathy-0.462
Instability index50.36
Isoelectric point4.92
Molecular weight168862.74
Publications
PubMed=23704180

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP31194
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.89|      15|     350|     981|    1000|       1
---------------------------------------------------------------------------
  981- 1000 (24.52/21.51)	QTDPSkssnpFPIQPPQLEV
 1339- 1353 (28.36/13.17)	QTDPS.....LRILPPQIRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.13|      39|     350|     484|     527|       2
---------------------------------------------------------------------------
  484-  527 (63.76/42.43)	HHPGGPTPSfdgAVTTPGNPahLFSHD.....LET..TNPSTSIMNT..ADTD
  841-  888 (55.37/25.95)	YEPSAGTPQ...SIIEPHIP..IFESDpadwsLTPyfTSPEPDIQPSglSDLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.16|      31|     358|    1048|    1079|       3
---------------------------------------------------------------------------
 1048- 1079 (55.10/37.38)	DIfLDQMRGAYESFRFGGHDRIM.F.PESPSGLL
 1418- 1450 (48.06/27.41)	DI.TDQTWGAILSHRLNNSNSLLeFnPALISGYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.11|      35|     358|     316|     373|       4
---------------------------------------------------------------------------
   43-   79 (60.28/31.11)	ETAWRNHGNLVYYDAKREGIWVFQPSPNSpnKALDEG
  318-  352 (66.82/81.04)	DHSWRFHGTTIKSWQSRCLDWLSTKGFDS..SLIDEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     258.07|      85|     531|      84|     218|       6
---------------------------------------------------------------------------
   84-  171 (126.13/147.88)	SQANLPSVRG..VELVKKDKG.TYEPSYLAKSKSMLAASLNTPNSaSSPSPLENALRNAQNVnARAMQVNSAQ..NLHDPAgSSPGVKSVASI
  223-  312 (131.93/65.11)	AYYQSPKVSDdtVTLVDLDISlTSLGALMIKACSYVTPGLQSINH.TSPEKLQRILSQGTEL.WLAPGGNPAKfySFYDDE.QLPGIQPISDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.94|      34|     531|     175|     218|       8
---------------------------------------------------------------------------
  175-  218 (42.56/55.18)	FAF.LKEVQEHFisSVQGSIMYklcNDHGLIPlnsrTLLLPSEsP
  713-  747 (60.38/39.23)	FEYsLTEVDEKY..GYNGRFRY...SDDDLKP....QLVEPHD.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.14|      20|      41|    1354|    1375|      10
---------------------------------------------------------------------------
 1354- 1375 (35.54/22.56)	PPPSmtTSQPTTTPVSTP....QASQ
 1392- 1415 (31.59/13.84)	PTPS..EAQSTSTPAVPPepddQSSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.50|      25|      41|    1226|    1250|      11
---------------------------------------------------------------------------
 1226- 1250 (43.80/30.34)	SPALLQENSCLHIAYAQSIDERWIT
 1265- 1289 (44.70/31.13)	SYCLGRKNEPFTLLFTDVANEIWET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.11|      14|      18|     585|     600|      13
---------------------------------------------------------------------------
  585-  600 (18.45/20.91)	EHQSGSAvEPnLPPAP
  606-  619 (25.66/15.56)	EKSSVSS.KP.LVPQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.42|      42|     916|     373|     418|      14
---------------------------------------------------------------------------
  373-  418 (65.37/53.54)	DIPSSDEgaiVPWPTLLCFRAI.KTSTTDLQP..SSANSFGLVDpLTFV
 1292- 1336 (62.05/38.04)	DLISSKK...VHWRIIIAKTAVmEQSEIDFWTglASTESNGSIS.LTLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.86|      16|      18|     898|     913|      15
---------------------------------------------------------------------------
  898-  913 (29.37/19.07)	DQAAPGTLRVNDQICQ
  919-  934 (27.49/17.39)	DQATFATRRLMTDVLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.32|      32|      45|    1105|    1147|      16
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 1116- 1147 (56.09/42.31)	NVVVYFVYPLN....NSSLLVNICTAFKHL.FKVYRK
 1158- 1194 (45.24/17.36)	NELVLQLVPLDfmaaPNSLIVPSPAEYSRLaMEVYDR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31194 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALRLPPQGRPMPNPRAAQQTDPSKSSNPFPIQPPQL
2) EERASIMSNRQQERNVLKAAKEQADQEAQNIRANNHSTALLEKGSNAGAMYPTPPDAIHHPGGPTPSFDGAVTTPGNPAHLFSHDLETTNPSTSIMNTADTDNWVTSEQKHRSNSNMNFEENENDNDNLFGDMGGDLF
3) RILPPQIRIPPPSMTTSQPTTTPVSTPQASQSSVFSPGNASTPTANAPTPSEAQSTSTPAVPPEPDDQSSRLL
4) SLNTPNSASSPSPLENALRNAQNVNARAMQVNSAQNLHDPAGSSP
5) TDITDADFNFFDQPDDIEMEHQSGSAVEPNLPPAPQHKIVEKSSVSSKPLVPQPTSKDTIMKDSQPTENNKRQPTFDQRFATSEMDMDVEMSNNNDNLIASAQPPLPP
963
426
1345
119
566
998
563
1417
163
673










Molecular Recognition Features






MoRF SequenceStartStop




1) APFDKEIVFGQLA
2) TDADFNFFD
677
569
689
577