<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31188

Description Putative mediator of rna polymerase ii transcription subunit 22 protein
SequenceMASQKETNTTGTNSNDNGEGPRQKAQSGPPPTSVPLRKRTASITNADIFEKLTGTREGAPPDMWTTEEKRRLDEEQEQQDLPQAEDGSRSGSQQQQQQQDDKENGKENEEETANDEPSDILDRHNKAMATILSRFLNMVNAATDPPPQGAVIEHASLNRLAMRTETAALVNEIQGLYVLNREIKGLWLQGPLRKPGEGSAPQQANNAPQPQPQPQPQQAAGKMASETKAKMERSLEILKKLEELHVEEQVQKARAAVVAANGDGEKKGKGKEKEGEGEGEDEGDGEKKNGKDEVMGGNK
Length299
PositionHead
OrganismEutypa lata (strain UCR-EL1) (Grapevine dieback disease fungus) (Eutypa armeniacae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Diatrypaceae> Eutypa.
Aromaticity0.02
Grand average of hydropathy-1.234
Instability index58.55
Isoelectric point4.97
Molecular weight32616.42
Publications
PubMed=23723393

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31188
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.15|      14|      16|      67|      80|       1
---------------------------------------------------------------------------
   67-   80 (23.10/12.07)	EEKRRLDEEQEQQD
   85-   98 (22.04/11.17)	EDGSRSGSQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.45|      23|     176|      18|      41|       2
---------------------------------------------------------------------------
   18-   41 (40.62/19.72)	GEG..PrQKAQSGPPPTSVPLRKRTA
  196-  220 (40.83/16.38)	GEGsaP.QQANNAPQPQPQPQPQQAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.70|      26|     160|     100|     126|       3
---------------------------------------------------------------------------
  100-  126 (40.91/22.82)	DDKENGKENEEEtANDEPSDILDRHNK
  263-  288 (44.79/21.43)	DGEKKGKGKEKE.GEGEGEDEGDGEKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31188 with Med22 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EQVQKARAAVVAANGDGEKKGKGKEKEGEGEGEDEGDGEKKNGKDEVMGGNK
2) ILSRFLNMVNAATDPPPQGAVIEHASLNRLAMRTE
3) MASQKETNTTGTNSNDNGEGPRQKAQSGPPPTSVPLRKRTASITNADIFEKLTGTREGAPPDMWTTEEKRRLDEEQEQQDLPQAEDGSRSGSQQQQQQQDDKENGKENEEETANDEPSDILDRHNKAMA
4) WLQGPLRKPGEGSAPQQANNAPQPQPQPQPQQAAGKMASETKAKMERSLEILKKLEELHV
248
131
1
187
299
165
129
246










Molecular Recognition Features






MoRF SequenceStartStop




1) KKGKGKEKEGEGEGED
2) KKNGKDEVMGGN
3) SVPLRKRTASITNADIFEKLTGTRE
266
287
33
281
298
57