<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31185

Description Putative transcription mediator subunit med12 protein
SequenceMTTKPLVGSQAQRQSQRSLNSNITSRPSPQRSLSSTSPTRRHNEALIDLTLDVPDSTSARYGQTSRAGGSRLKQEISNDSRSSVQADESSLAPSNSISNRQSLPSRGRPQLHSDILRMRASKSILLSDQTHSQTPAKPFAFPVRPGQHPPPSLGRPSPSIGPTGKRDARPKPFVLEVPLAAPSYSPNGHADFFPWNGNHAEDQFSEPVIRQGFFDKSQMSQNETGSAKASIYPSLKHKSGLQTLSSLFTSVLAQRRAHGNITADSTFKPPPRVTVTDTKREIWLKDLANPTISLRRLSRSIPHGIRGKVLLEHALNKNIPIERAVWLAKCVGANELRSFKRKGAGGAFAMGGEAKWVRDFTVSVEQVLENIIGSCGEKDFRRRIYYAIRLAAHFHAECLLDREHYIDWILSSLETTSQAKLPMWLLIAQMYWEDILKYRRFGRRFTTVLLNRFSETIKHPDADILGPLIGRLRILLTKLMTLNPDNFVSPEIWSKHREVLHAYLSYSDELPISVWDEINRRNMRLTTLAPEAQHPPQQRLFDILDKSLFALFTPEIIDICWQLDDDKTALVHAILDWSTSCYRPGHAKVFIGARIIRAWRRLGTDTTAVTLSFLDSSACEIGRNKASFYHLVSELVRSNDFCIPTYLQWLISRGGIHDHSDLAPDGPCGTRLLAELPIQNLSEEMAGLRRSLLYRAEYPIDTEDRKVAASISNISNAFRMMPIASERRLPQVDRYFRDLDDIQSLNRTSKSHIGSWLLREVELQMLPSSKPLNQWGNPSPAAHDACGLTAAAFVMVRDFLESVDDFTILAEVIKIATASADPQTISSCADTLNLHAEVFAGIGATKDLFDVLINRARSFADDRDIMPRAVLGSLLDLSFKMPEHQLLTAQLARQLALSDRKCVADACSPVSDHVAGGSQNNEVEFVDEIEKLLANGTSIDRGTMERLFQRVTHHLSISLDKSPEQQRKCVSLLTTLRDFNPQPFDLLMASWLPYIQKSEQRPSMVKIWGPMIGLGCFSMKDLVDASLKSEKDDSNSSTTVSMELLALIATPLSLPEILTSDEAYRVRIVQSRMPIDNPELTLTVIRSAIEACSAAVHNMQPITFQTLNILGSSAMHDLLQTLVLVGGDMIGRIMVHPLLSGTANQEASKVLGASINKLLVPTYHIETFDISVGDALKSANYLNLPFCQLKVASTFRSGKVPQAISRNMVSPHLDDLDRAVESAIMAGGTTWACIVPSLDLTAVHHLRRGAETQLLRLFHAAKASGYYDILEEEHQLSKAESLMVILDLTIDKIYTEKINTSHSSQSCFPEVVTLLNNASQCFASAQPNSCKVTYLTKWLPLLLSFTTSQTVALEPSKVGNEHRGRAILCLTAIFLDLYRFKANTKTQHLPLQQCFDLILNMVDVLPDDIRQQCSRNFRDTASNPITSYIYSIMAPPSDWLHIYQSGTKATAAGRNISNTNTDHARDSSRQSFPFTMKRWEMLGEPSANMGENDTSLSLTLFASRKGVN
Length1508
PositionKinase
OrganismBotryotinia fuckeliana (strain BcDW1) (Noble rot fungus) (Botrytis cinerea)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Botrytis.
Aromaticity0.07
Grand average of hydropathy-0.244
Instability index52.16
Isoelectric point8.35
Molecular weight168023.86
Publications
PubMed=23704180

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31185
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     179.00|      51|     239|      16|      73|       1
---------------------------------------------------------------------------
   16-   67 (83.29/48.98)	QRSLNSNITS....RPSPQRSLSSTSPTRRHNEALIDLTLDVPdSTSARYGQTSRA
  155-  190 (58.30/30.24)	..............RPSP.....SIGPTGKRDARPKPFVLEVP.LAAPSYSPNGHA
  254-  287 (37.41/12.93)	QRRAHGNITAdstfKPPPRVTVTDT....KREIWLKDL..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.70|      47|     238|     753|     827|       2
---------------------------------------------------------------------------
  326-  372 (83.66/46.37)	WLAKCVGANELRSFK......RKGAGGAFAMGGEAK...WVRDFTVSVEQ..VLENII
  756-  813 (66.04/84.96)	WLLREVELQMLPSSKplnqwgNPSPAAHDACGLTAAafvMVRDFLESVDDftILAEVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.83|      29|     458|     510|     556|       3
---------------------------------------------------------------------------
  510-  543 (40.13/30.44)	LPISVwD...EINRRNMRLTTLAPEaqHPPQQrlFDI
  955-  986 (45.70/17.54)	LSISL.DkspEQQRKCVSLLTTLRD..FNPQP..FDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.73|      29|     458|     401|     430|       4
---------------------------------------------------------------------------
  401-  430 (49.65/40.90)	DREHYIDWILSSLETTSqAKLP.MWLLIAQM
  862-  891 (47.08/33.09)	DRDIMPRAVLGSLLDLS.FKMPeHQLLTAQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.43|      61|     345|     988|    1116|       5
---------------------------------------------------------------------------
 1047- 1116 (86.19/143.83)	LIatpLSLPEILTSDeayrVRIVQSRMPID...NPeLTlTVIRSAIEACSAAVHNMQPITFQTL...NILGSSAMH
 1397- 1463 (102.24/40.98)	LI...LNMVDVLPDD....IRQQCSRNFRDtasNP.IT.SYIYSIMAPPSDWLHIYQSGTKATAagrNISNTNTDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.91|      27|     541|      89|     115|       6
---------------------------------------------------------------------------
   89-  115 (48.49/32.08)	SSLAPSNSI...SNRQSLPSRGRPQLHSDI
  633-  662 (44.42/28.67)	SELVRSNDFcipTYLQWLISRGGIHDHSDL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31185 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTTKPLVGSQAQRQSQRSLNSNITSRPSPQRSLSSTSPTRRHNEALIDLTLDVPDSTSARYGQTSRAGGSRLKQEISNDSRSSVQADESSLAPSNSISNRQSLPSRGRPQLHSDILRMRASKSILLSDQTHSQTPAKPFAFPVRPGQHPPPSLGRPSPSIGPTGKRDARPKPFVLEVPLA
1
180










Molecular Recognition Features






MoRF SequenceStartStop




NANANA