<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31183

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGLHNGLPTNHDRNRDHGQLANGSTGDMKAMVNGNGDATMNQPQRSPMPSASRMNDLPDEIQHITQGFVPLGVLVSRLAQTTHNSLQERITALARIQVSGAPPAVNGNAAHSSSLSDDVTPENLTKKTELLNFIQATHARWVKALVIAAWSRKAEPVSKLIDLYNCINVQKNEYEVGLNSLMNVKRDLTFARLQNPDLKTALQVLATGDASWMPDLNYIEPPPISPKEQLQWIEELNTLLSLRLNLEDHDKVPYHFQDYSIESGRVTFKVPGEFEVDLTIADEDFEKQYWFVDFRFLFEPAPAELSAASRAYLERRLDEEVLATEGLQGCYNFLHEFVLTHKITEYVRQAIELSKEQWVDTLKIERLNRAMAIQYWLNRYPAEGPKSWIIVGVHSGKTPGVPSSPSSTSHLTLRWFRDNKEVKDVAIPFDEATVSTQQLLNKVIGKHIEHILGTIHSKLKAKGKFIRREASLDLKISEHEPMESSLKMQLGYKDYVTVKIAPTTGLFALMPQTNVTFNGEKMLNYQMKDPAEEGLNCLEYVRLHYVADAMNRRGKSLGWHKCKGPVKPDDIKTMLNTREGFQTMWFRRHGWEKQWYLMLSLSMAGDRWWLIEVFFANLTVFTAGVISHLANLRTLHSRKVKHTTRDAPSCSLPSGIKIPSVFIRLSDILDTDRSPGAKKRDVSWAVDFVQIMFKGIENSPSKIQPKPSKTPGSTGAEEESRLGILVDARFKVADPERFSLLKGNVERDVAFNKRLGVFALRLRADVGRTILDTLAYRLRAIERLVDCIDAIRRSSRDIRCENITLNQVTFTYSDRPNANSDAVAQHDIRRWKASLLFQESKVKLELERGNPHLRIIDLLCRLVNSNLRFEKLPYFLSSTLPVMRALDSIEEAWKDLGPRSVGRVEVFPVYLDWTSIRYTLPGPNNKGAERRLTLRLRLQFHRGETMWHVDRAEPGMASLPDDAFKKALTRVWGAENRVWENLIFSAAVRADDRVETLLKAIDDAIRPLTIQSPTMTRQAPPKMQQSQHAQQQQHQQQRNQAQNHALNQKAMANKARQQQQQQQQQQQQYQPPRQQPGQGQVVILDD
Length1088
PositionTail
OrganismEutypa lata (strain UCR-EL1) (Grapevine dieback disease fungus) (Eutypa armeniacae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Diatrypaceae> Eutypa.
Aromaticity0.08
Grand average of hydropathy-0.495
Instability index47.03
Isoelectric point9.06
Molecular weight123995.98
Publications
PubMed=23723393

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31183
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.92|      30|      30|    1013|    1042|       1
---------------------------------------------------------------------------
 1013- 1042 (56.89/35.13)	QSPTMTRQA....PPKMQQSQHAQQQQHQQQRNQ
 1044- 1077 (50.03/29.98)	QNHALNQKAmankARQQQQQQQQQQQQYQPPRQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.58|      15|      31|     723|     739|       2
---------------------------------------------------------------------------
  723-  739 (18.42/22.89)	RLGILvDARFKvADPER
  756-  770 (26.16/18.73)	RLGVF.ALRLR.ADVGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.37|      17|      19|     338|     354|       3
---------------------------------------------------------------------------
  338-  354 (29.11/20.10)	EFVLTHKITEYVRQ.AIE
  359-  376 (25.26/16.48)	QWVDTLKIERLNRAmAIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.38|      12|     304|     287|     307|       4
---------------------------------------------------------------------------
  214-  225 (27.34/ 8.89)	WMPDLNYI.EPPP
  292-  304 (21.04/14.03)	WFVDFRFLfEPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.35|      27|      31|     831|     859|       5
---------------------------------------------------------------------------
  831-  859 (41.73/26.56)	RRWKASLLFQesKVKLELERGNPHLRIID
  863-  889 (45.62/23.83)	RLVNSNLRFE..KLPYFLSSTLPVMRALD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.72|      34|     169|     379|     419|       7
---------------------------------------------------------------------------
  379-  419 (48.47/47.11)	LNRypaEGpKSwiiVGVHSGKTPGVPSSP....SSTSHLTLRWFR
  552-  589 (63.25/35.96)	MNR...RG.KS...LGWHKCKGPVKPDDIktmlNTREGFQTMWFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.77|      12|      30|     446|     462|       8
---------------------------------------------------------------------------
  446-  462 (15.44/23.72)	IGKHiehilGTIHSKLK
  478-  489 (21.34/14.34)	ISEH.....EPMESSLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.05|      34|     171|       2|      40|       9
---------------------------------------------------------------------------
    2-   40 (49.67/44.71)	ENGLhNGLpTNHDRNRDHGQLANgstGDMKA..MVNGNGDA
  177-  212 (54.38/30.87)	EVGL.NSL.MNVKRDLTFARLQN...PDLKTalQVLATGDA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31183 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IRPLTIQSPTMTRQAPPKMQQSQHAQQQQHQQQRNQAQNHALNQKAMANKARQQQQQQQQQQQQYQPPRQQPGQGQVVILDD
2) MENGLHNGLPTNHDRNRDHGQLANGSTGDMKAMVNGNGDATMNQPQRSPMPSASRMNDLPDEI
1007
1
1088
63










Molecular Recognition Features






MoRF SequenceStartStop




1) QVVILDD
2) QYQPPR
1082
1070
1088
1075