<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31169

Description Putative rna polymerase i activation mediator protein
SequenceMTSRPSLGVSQRQPQRTLSGSGLSQRPTHQRTLSQQYLPQSPIRRSDSFNDQNSDVPDGSQGRYPTAPRRGGSKLKLELANDGIEHAGFSESPQNLDPLSASRVFTPSLWLKDLANPSISLRRLSRTIPHGIRGRVLLDQCLNKNVPTDRAVWLAKCVGANEIRAFKRKGVNGTFVMGGETKWIRDWTVNVEQFVETVSNSFSDDDWKAKVTYASSVRTQPAMRSTLVKALDNLLRMPNNDDMAAQLWKISDDKSGLIRTVLEWCTSLYRSGVAKVYVAATVFRSWSTFDVDITGSILNFLDTDPLHEPSRKRLVYHLVSELVRSGHYSVPQYLQWLIARGGLCDPYQTNPDGPCGTRLLVELPTQSLSDSMRSLRATLLRRASYLVEDEANDIATAIKCIKYALSIPLEADDPIMWKKPMSIKKLAQRVGLSSRALRSEVCSWLSHDIVWALDMNFQSGKGGLQLSSIKFEAVRTLLEKAQDFTMLAHFLRVVSKTSNADILGQCADAISLHLPVFAATGAAKSLFECLYDRLKALAEEQGLGVRPLLAALANLAPRLPGFKDVASQLRNELIRTDRSNAVDASSPLSDNMAVQLQDHETELNEQIEKLASYSSADRPTMERLFQAIVRRYESCWSKADERQRPYCMLLTRLRVFDPQHFDMMMRALLVPDGNDGQKSFEQVLELANEFTLPFCQVKLSLNLATDDASGADGPERIQSQLELLSKAMDNAIDANNVMWTGMLSRLTPEITQHLKGRAELRFLELLPSLRNQSIAEGALDADFHMAENLLTVIDSTIRGTATPKPSPFSSSMVDKLADIWEILASTNPEHAVLKADVLSRWLPLVLSYLALLASLCAASATDSSAASKVAATNGGEVRGRALLVLAGLVQELDNGHFSSAPSSNSNSLDQNRATALGQRAFDIALIFADGLPEDARQQCARAVRDATSDPRLRYLFSFDPPSAAGAAGSSSLMLAQREKLATTNTPGQSQSQEQQQQQQRRALAAANMAAMMGIGGVGGIAPERLAPFQLRRWEILSEPTPNVGENDTSLSLTLFDARKL
Length1060
PositionKinase
OrganismEutypa lata (strain UCR-EL1) (Grapevine dieback disease fungus) (Eutypa armeniacae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Diatrypaceae> Eutypa.
Aromaticity0.06
Grand average of hydropathy-0.266
Instability index44.52
Isoelectric point7.55
Molecular weight116827.51
Publications
PubMed=23723393

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31169
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     884.63|     257|     293|     194|     486|       1
---------------------------------------------------------------------------
   36-  235 (218.31/114.70)	...................................................................................................QYLpQSPIRRSdSFNDQNSDVPDGS.QG..RYPTA..PRRGGSKLKLELANDGIE.....HAGF.SESPQNLDPLSASRVFTPSLWLK.DLANP.....SISLRRLSRTIphGIRGRVLLDQ.ClnknvptdraVWLAK.CVGANEIrA......FK..RKGVNGTFVMG.GETKWIR...........DWTVnveqFVETVSNSfSDDDWKAKVTYASSVRTqPAMRST.LVKALDNLL
  236-  530 (403.74/267.41)	RMPNNDDMAAQLWK..ISDDKSGlirtvlewctslyrsgvakvyvaatvfrswstfDVDITGSILNFLDTD.PLHEPSRKRLVYHLVSeLVRSGHYSVPQYL.QWLIARG.GLCDPYQTNPDGP.CG..TRLLVELPTQSLSDSMRSLRATLLR.....RASY.LVEDEANDIATAIKCIKYALSIPLEADDPIMWKKPMSIKKLAQRV..GLSSRALRSEVC..........SWLSHDIVWALDM.N......FQSGKGGLQLSSIKF.EAVRTLLEKA.......QDFTM.lahFLRVVSKT.SNADILGQCADAISLHL.PVFAATgAAKSLFECL
  558-  785 (262.57/139.40)	RLPGFKDVASQLRNelIRTDRSN.................................AVDASSPLSDNMAVQlQDHETELNEQIEKLAS.YSSADRPTMERLF.QAIVRRY.ESCWSKADERQRPyCMllTRLRVFDP.QHF.DMM..MRALLVPdgndgQKSFeQVLELANEFTLPF.C.QVKLSLNLATDDASGADGP...ERIQSQL..ELLSKAMDNAI.............DANNVMWTGML.SrltpeiTQHLKGRAEL...RFlELLPSLRNQSiaegaldADFHM...............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.14|      44|     103|     818|     864|       2
---------------------------------------------------------------------------
  818-  864 (67.20/39.77)	DIWEILASTNPEHA...VLKA..DVLSRwlPlVLSYLALLASLCAASATDSS
  922-  970 (69.94/32.45)	DIALIFADGLPEDArqqCARAvrDATSD..P.RLRYLFSFDPPSAAGAAGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.88|      26|     962|       6|      31|       4
---------------------------------------------------------------------------
    6-   31 (45.73/27.44)	SLGVSQRQPQRTLSGSGLSQRPTHQR
  971-  996 (44.15/26.23)	SLMLAQREKLATTNTPGQSQSQEQQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31169 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LAQREKLATTNTPGQSQSQEQQQQQQRRALAA
2) MTSRPSLGVSQRQPQRTLSGSGLSQRPTHQRTLSQQYLPQSPIRRSDSFNDQNSDVPDGSQGRYPTAPRRGGSKLKLE
974
1
1005
78










Molecular Recognition Features






MoRF SequenceStartStop




NANANA