<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31168

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDKHLDTRFDRVEKALGTLADSIAKYNPSTNSAREFVAADAELGKGLEELQTHQFNHRRLQDLRTASASLDAQIKDTLRLLANTRKELVSTPATVFPDGARHYYDIDYDELLRYARIISKTTMPPVLPAEPGISAAAPGEGVGVGGGGGSGIETAVTTPGGMATPGGGGNGGATPNGVQSSSAAAATNGMATPLPSQQSSSTNEPPPSSQQPPISTAGTSFNTVASTNTNTTLPEHINAHLNPQAAFEFAPWPGEDGVRGGGLAALAFLADRGVDPEGYDPEEEKKRREREEEEEKRKREEREREDRERRTREEQARLRARESEQAEAWRRASVVGGPGPGAGGVGGAGGVVPASSPTGEKRQFQFMGDLDDDDD
Length375
PositionMiddle
OrganismEutypa lata (strain UCR-EL1) (Grapevine dieback disease fungus) (Eutypa armeniacae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Diatrypaceae> Eutypa.
Aromaticity0.05
Grand average of hydropathy-0.774
Instability index57.28
Isoelectric point4.99
Molecular weight39770.99
Publications
PubMed=23723393

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364141
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31168
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.76|      17|      18|     132|     149|       1
---------------------------------------------------------------------------
  138-  158 (22.23/ 9.94)	PGEGvGVGGGGGsGIETAvtT
  340-  356 (32.54/12.67)	PGAG.GVGGAGG.VVPAS..S
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.84|      13|      17|     170|     182|       2
---------------------------------------------------------------------------
  170-  182 (26.38/16.58)	NGGATP.NGVQSSS
  188-  201 (23.46/13.89)	NGMATPlPSQQSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.08|      17|      17|     282|     298|       3
---------------------------------------------------------------------------
  282-  298 (28.33/15.93)	EE.EKKRREREEEEEKRK
  300-  317 (24.75/13.12)	EErEREDRERRTREEQAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.94|      49|     212|       7|      62|       4
---------------------------------------------------------------------------
    7-   62 (70.24/46.22)	TRFDRV..EKALGTLADSI.AKYNPstNSAREFVAADAELG.KGlEELQTHQFnhrrLQD
  219-  271 (76.70/34.87)	TSFNTVasTNTNTTLPEHInAHLNP..QAAFEFAPWPGEDGvRG.GGLAALAF....LAD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31168 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPPVLPAEPGISAAAPGEGVGVGGGGGSGIETAVTTPGGMATPGGGGNGGATPNGVQSSSAAAATNGMATPLPSQQSSSTNEPPPSSQQPPISTAGTSFNTVASTNTNTTLPEHINAHLNPQAAFEFAPWPGEDGVRGGGLAALAFLADRGVDPEGYDPEEEKKRREREEEEEKRKREEREREDRERRTREEQARLRARESEQAEAWRRASVVGGPGPGAGGVGGAGGVVPASSPTGEKRQFQFMGDLDDDDD
123
375










Molecular Recognition Features






MoRF SequenceStartStop




1) EAWRRASVVG
2) VVPASSPTGEKRQFQFMGDLDDDDD
327
351
336
375