Description | Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MDKSTSSTQTTIHNLHNLETHLESLIHNLHDLGKIIHDFENSKTNEIIFNRIKNIINNYKSLYTNKDFITEIVPRDVIDYIEEGRNPDVYTRQFCELVQKDNQYVNGKSIAITDFRNILAQDIKNNFPNIANEVEKILRNTNKN |
Length | 144 |
Position | Middle |
Organism | Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent) (Pneumocystis carinii f. sp. muris) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Pneumocystidomycetes> Pneumocystidaceae> Pneumocystis. |
Aromaticity | 0.08 |
Grand average of hydropathy | -0.699 |
Instability index | 36.67 |
Isoelectric point | 6.05 |
Molecular weight | 16873.70 |
Publications | PubMed=26899007 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364146 |
GO - Cellular Component | mediator complex GO:0016592 IEA:EnsemblFungi |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP31164 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 49.41| 17| 18| 54| 70| 1 --------------------------------------------------------------------------- 35- 54 (21.28/ 8.36) IIHDFENSKTNEIIfnrIKN 55- 71 (28.13/12.72) IINNYKSLYTNKDF...ITE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 45.44| 15| 18| 110| 125| 2 --------------------------------------------------------------------------- 110- 125 (20.83/17.18) IAiTDFRNILAQDIKN 130- 144 (24.61/15.19) IA.NEVEKILRNTNKN --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FITEIVPRDVID 2) IFNRIK | 68 48 | 79 53 |
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